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| Number | Title | Issue Date |
| 7390829 | Alpha-2 adrenergic agonists A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto... | 06/24/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7358269 | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one A compound of the formula or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed. ... | 04/15/2008 |
| 7345077 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4- (substituted cycloalkylmethyl) imidazol-2-ones and 4- (substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 03/18/2008 |
| 7335778 | Intermediate for biotin and process for producing the same The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I): | 02/26/2008 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7220770 | Heterocyclo-substituted imidazoles for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (V), wherein R3 is a radical selected from hydrido, alkyl, haloalkyl, aralkyl, heterocycloalkyl, heteroaralkyl, acyl, cy... | 05/22/2007 |
| 6960688 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ... | 11/01/2005 |
| 6916837 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 ... | 07/12/2005 |
| 6787552 | PPAR delta activators Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 ... | 09/07/2004 |
| 6706739 | Imidazolidinone compounds A compound having the formula: in which R1, R2, R3, T, W, m, x, and y are defined as in the specification. Also disclosed is a method of treating enterovirus infection by using a compound... | 03/16/2004 |
| 6646009 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof N-(Aryl)-2-arylethenesulfonamides and pharmaceutically acceptable salts and compositions thereof are useful as antiproliferative agents, including, for example, anticancer agents. They are also useful as radioprotective agents.... | 11/11/2003 |
| 6635630 | Selective neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --S--, --SO--, ... | 10/21/2003 |
| 6613789 | Heterocyclo-substituted imidazoles for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by Formula V: ##STR1## and pharmaceutically-acceptable salts thereof.... | 09/02/2003 |
| 6528535 | Bicyclic inhibitors of protein farnesyl transferase The present invention provide compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable... | 03/04/2003 |
| 6436928 | Selective neurokinin antagonists A compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --SO0-2 | 08/20/2002 |
| 6403805 | 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatves The present invention describes compounds useful for treating warm-blooded animals suffering from disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase IV (PDE IV), and/or disease states related to a physiologically de... | 06/11/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
| 6369273 | Chemical compounds and their use to elevate pyruvate dehydrogenase activity The use of a compound of the formula (I): ##STR1## wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A--B is selecte... | 04/09/2002 |
| 6312538 | Chemical compound suitable for use as an explosive, intermediate and method for preparing the compound A new compound, 1,1-diamino-2,2-dinitroethylene suitable for use as an explosive, as well as an intermediate for preparing the compound consisting of a heterocyclic 5- or 6-ring of the general formula ##STR1## wherein n=at least 1. The compound is prepare... | 11/06/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6179906 | Cyclic urea surfactants This invention provides water-based compositions, particularly coating, ink, and agricultural compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain cyclic urea compou... | 01/30/2001 |
| 6172060 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The ... | 01/09/2001 |
| 6147097 | Imidazole derivatives as anti-HIV agents An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R1 represents hydrogen, C1 | 11/14/2000 |
| 6136983 | Pesticidal sulfur compounds Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining s... | 10/24/2000 |
| 6114539 | Mercapto-imidazolyl derivatives The present invention provides mercapto-imidazolyl compounds, and the acid addition salts and metal salt complexes thereof; a process for their preparation; and a method for their use as microbicides.... | 09/05/2000 |
| 6107322 | Pesticidal 1-polyarylimidazoles A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.... | 08/22/2000 |
| 6090944 | Alkanoic acid derivatives as v integrin receptor antagonists The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors v댣, �... | 07/18/2000 |
| 6066662 | Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. The... | 05/23/2000 |
| 6063934 | Imidazolone anorectic agents: 1. 2-substituted-3,5-dihydro-5,5-diphenyl-4H-imidazol-4-ones A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of acyclic derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are e... | 05/16/2000 |
| 6060495 | Pesticidal sulfur compounds Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining s... | 05/09/2000 |
| 6057448 | Process for producing imidazole derivatives The present invention provides a process for producing a compound of the formula (III): ##STR1## wherein R1 and R3 are independently hydrogen or an organic group; R2 is an organic group; and R4 is an option... | 05/02/2000 |
| 6054591 | Lymph-absorbable aryl substituted imidazole derivatives A compound of the formula (I): ##STR1## salt thereof, or hydrate thereof which can effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high concentration is provided.... | 04/25/2000 |
| 6054590 | Imidazolone anorectic agents: II. phenyl derivatives A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expecte... | 04/25/2000 |
| 6046355 | Dihydropyrones with improved antiviral activity This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish... | 04/04/2000 |
| 5994376 | 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating allergic, atopic or inflammatory diseases The present invention describes 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating warm-blooded animals suffering from disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase IV (PDE IV), ... | 11/30/1999 |
| 5977377 | Process for producing N-alkylimidazole Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific surface area of 0.6 M2 /g or larger.... | 11/02/1999 |
| 5952510 | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives having PDE IV and cytokine inhibiting activity The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 each independentl... | 09/14/1999 |
| 5945413 | Aspartyl protease inhibitors This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This ... | 08/31/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
