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| Number | Title | Issue Date |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
| 6335451 | Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the formula I ##STR1## in which the symbols have the meanings indicated i... | 01/01/2002 |
| 6313296 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 11/06/2001 |
| 6054591 | Lymph-absorbable aryl substituted imidazole derivatives A compound of the formula (I): ##STR1## salt thereof, or hydrate thereof which can effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high concentration is provided.... | 04/25/2000 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5786373 | Fibrinogen receptor antagonists Novel fibrinogen receptor antagonists of the formula: X--Y--Z-Aryl-A--B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsu... | 07/28/1998 |
| 5643855 | Herbicidal imidazolones Compounds such as Formula I having herbicidal utility are disclosed: ##STR1## wherein Q is ##STR2## R1 is H; alkyl, haloalkyl or halogen R2 is C1 -C2 alkyl optionally substituted with one or more halog... | 07/01/1997 |
| 5612363 | N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R1 is --C(NH)NH2, --C(NH)N(H)OR11, --C(NH)N(H)C(O)R9, or --C(NH)N(H)C(O)OR11 ; R2... | 03/18/1997 |
| 5378842 | Imidazolium hardeners for proteinaceous materials An improved imidazolium hardener is described. These novel hardeners are specifically advantageous for hardening, or crosslinking, a hydrophilic colloid in a photographic element. The advance in the art is realized in A hardening agent chosen from the set... | 01/03/1995 |
| 5326780 | Imidazole derivatives having anti-HIV activity A novel imidazole derivatives of formula I: ##STR1## wherein R1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hete... | 07/05/1994 |
| 5319099 | 3-benzylidene-1-carbamoyl-2-pyrrolidone compounds useful as antiinflammatory agents The present invention relates to novel 3-benzylidene-1-carbamoyl-2-pyrroridone analogues having advantage anti-inflammatory activities, which is represented by the formula: ##STR1## wherein R1 and R2 each is independently hydrog... | 06/07/1994 |
| 5276147 | Compounds and complexes useful in medical imaging The subject of the present invention is compounds which correspond to the following general formula: ##STR1## in which R1 and R3 independently of one another represent H, an alkyl, alkenyl, cycloalkyl, aryl, arylalkyl or an alky... | 01/04/1994 |
| 5264581 | Radioiodinated angiotensin receptor antagonists Disclosed are novel radioiodinated imidazole Angiotensin II antagonists that are useful radioligands. An illustrative compound of this novel class of compounds is 4-chloro-N-[2-[4-hydroxy-3-(iodo-125I)phenyl]ethyl]-2-propyl-1-[[2'-(tetra zol-5-yl)biph... | 11/23/1993 |
| 5234917 | Substituted 5-(alkyl)carboxamide imidazoles Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and me... | 08/10/1993 |
| 5223525 | Pesticidal 1-arylimidazoles The invention describes novel 1-arylimidazoles of formula (I) ##STR1## wherein typically preferred substituents are: X is S(O)n R1, in which R1 is an alkyl group, preferably a methyl group, which is fully substituted ... | 06/29/1993 |
| 5183810 | Imidazole angiotensin II antagonists incorporating a substituted benzyl element Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##... | 02/02/1993 |
| 5034537 | Leukotriene antagonists This invention relates to (R)--methyl-4-halobenzenemethanamine salts of epimers of acids of the formula ##STR1## and the use of these salts to separate these epimers. These acids are leukotriene antagonists.... | 07/23/1991 |
| 5030726 | Polymerizable cyclic urea derivatives The present invention relates to polymerizable cyclic urea derivatives which can be thermally split to give rise to an isocyanate group; and to a polymer having cyclic urea pendant groups, which can be cured by heating without any additional curing agent ... | 07/09/1991 |
| 5023336 | Imidazole compound and process for preparing the same An imidazole compound is disclosed, which is represented by formula (I): ##STR1## wherein: X represents a --COOT group, in which T represents a hydrogen atom, an alkyl group, a benzyl group, or a phenyl group; or a --CONH2 group, Y represe... | 06/11/1991 |
| 4937253 | Ester prodrugs This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrie... | 06/26/1990 |
| 4874792 | Thiophenyl Alkanoic acids useful as leukotriene antagonists This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotri... | 10/17/1989 |
| 4859779 | Dopamine-ଲ-hydroxylase inhibitors Potent dopamine-ଲ-hydroxylase inhibitors having the formula ##STR1## that are useful to inhibit dopamine-ଲ-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopa... | 08/22/1989 |
| 4845233 | Imidazolin-2-ones A compound having the formula: ##STR1## wherein R, R1 and R2 are independently selected from hydrogen; hydroxy; fluorine; bromine; chlorine; C1 -C20 alkyl; C2 -C20 alkenyl; C2 | 07/04/1989 |
| 4832732 | 1-methyl-1H-imidazole-5-carboxylic acid derivatives and their use as herbicides Novel herbicidal 1-methyl-1H-imidazole -5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Further the invention also relates ... | 05/23/1989 |
| 4824670 | Carbazates The present invention relates to new carbazates of the general formula (I), ##STR1## wherein A is C3-10 alkyl, C3-10 alkenyl, C2-10 haloalkyl, trifluoromethyl, phenyl-C1-3 alkyl, phenyl-C2-3 -alkenyl,... | 04/25/1989 |
| 4820719 | Leukotriene antagonists This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in whi... | 04/11/1989 |
| 4777252 | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines Antibacterial activity is exhibited by 3-acylamino-2-oxoazetidines having in the 1-position an activating group of the formula ##STR1## wherein R is ##STR2## and R4 is ##STR3##... | 10/11/1988 |
| 4769386 | Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic composition containing them The imidazolylthio substituted alkanoic acids represented by the formula (I) or (IA) as defined herein have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.... | 09/06/1988 |
| 4764624 | 1,2,5-Substituted imidazole compounds and their use as growth regulators The compounds of the formula I ##STR1## wherein R denotes (substituted) phenyl, (substituted) cyclohexyl or (substituted) cyclohexenyl, X denotes a radical of the formulae ##STR2## Y denotes a radical of the formulae ##STR3## and the b... | 08/16/1988 |
| 4762850 | Dopamine-beta-hydroxylase inhibitors Potent dopamine-ଲ-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-ଲ-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopa... | 08/09/1988 |
| 4703054 | Nootropic imidazolidinones The invention relates to 4-imidazolidinone derivatives which help restore learning and memory difficulties associated with ageing. A compound of the invention is 1-(2-aminoacetyl)-2,2-dimethyl-4-imidazolidinone, of the formula: ##STR1##... | 10/27/1987 |
| 4615726 | Herbicidal 1-acylimidazolinones Compounds of the formula ##STR1## wherein A denotes N or CR4, B denotes a carboxyl, carbo-(thio) ester, (substituted) carboxamide or carboxanilide, carbohydroxy(alkoxy)-amide, (substituted) carbohydrazide or (substituted) oxazoline group, ... | 10/07/1986 |
| 4614535 | Herbicidal imidazolinones Imidazolinones of the formula ##STR1## in which A denotes N or C--R4 ; B denotes halogenoalkyl, alkoxymethyl, cyanomethyl or thiocyanatomethyl; X denotes alkyl; and Y denotes alkyl, cycloalkyl, alkenyl, phenyl or benzyl; or X and Y, togeth... | 09/30/1986 |
| 4602093 | Novel substituted imidazoles, their preparation and use Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit cardioselective ଲ-adrenergic blocking activity, and are useful as antihypertensive agents, cardioprotective agents, antiarrythmi... | 07/22/1986 |
| 4592774 | Herbicidal alpha heterocyclic carbinol carbamates, ureas and N-alpha-substituted acetylcarbamates Novel heterocyclic carbinol carbamates, ureas and N-acetyl-carbamates are provided which exhibit primarily preemergence control of broadleaf weeds with good selectivity for corn and certain other crops.... | 06/03/1986 |
| 4556516 | Process for the preparation of acylureido penicillin derivatives A process for the preparation of acylureido penicillin derivatives is disclosed. In particular this invention concerns an economical process for the preparation with high yield of penicillin derivatives of the formula ##STR1## where R1 rep... | 12/03/1985 |
| 4503235 | Process for producing 4-carbamoyl-1H-imidazolium-5-olate A process is provided for producing 4-carbamoyl-1H-imidazolium-5-olate (I) ##STR1## by reacting aminomalonamide H2 N--CH(CONH2)2 and formamidine CH(.dbd.NH)NH2 compound in a liquid medium comprising alcohol... | 03/05/1985 |
| 4410696 | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives There are provided compounds of the formula: ##STR1## wherein R is a mono-substituted benzoyl group wherein the substituent is a phenyl group, an alkanoyl group, a formyl group, a halogeno-alkyl group, an aralkyloxy group, a phenoxy group, an alkoxyc... | 10/18/1983 |
| 4403096 | Optically active imidazolidin-2-one derivatives A novel optically active cis-4,5-disubstituted imidazolidin-2-one derivative of the formula: ##STR1## wherein R1 is a C1 -C4 alkyl group or benzyl and R2 is a chiral aralkyl group optionally having at least... | 09/06/1983 |
| 4380548 | N-(2, 6-Dimethylphenyl)-4,5-dihydro-4,4-dialkyl-2-methylthio-1H-imidazole-1-car boxamides, anticonvulsive composition and method The invention provides new N-(2,6-dimethylphenyl)-2-methylthio-1-imidazolidinecarboxamides and their pharmaceutically acceptable salts which are useful as anticonvulsant agents. Also provided are methods for preparing the compounds of the invention, ... | 04/19/1983 |
