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| Number | Title | Issue Date |
| 8129544 | 1-substituted-4-nitroimidazole compound and method for preparing the same The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a pheny... | 03/06/2012 |
| 7423158 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyl... | 09/09/2008 |
| 7368572 | Acetylene derivatives as inhibitors of histone deacetylase The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7354965 | Azo compound, colorant-containing curable composition, and color filter and method of producing the same The present invention provides a novel azo compound, a curable composition comprising a colorant superior in the light-fastness and heat resistance of a dye, pattern-forming characteristics (developing characteristics) and liquid preserving characteristics, a color ... | 04/08/2008 |
| 7238699 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 07/03/2007 |
| 7053056 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inf... | 05/30/2006 |
| 6797828 | Processes for the preparation of 4(5)-amino-5(4)-carboxamidoimidazoles and intermediates thereof The invention provides novel processes for preparing efficiently compounds of general formula (1) (wherein R1 and R2 are each independently hydrogen, optionally substituted C1-C10 alkyl, C3-C14 hydrocarbyl bearing alicyclic skeleton, or the like) and initermediates ... | 09/28/2004 |
| 6635630 | Selective neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --S--, --SO--, ... | 10/21/2003 |
| 6596739 | N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent; A is aryl or heterocycle; and pharmaceutically acceptable ... | 07/22/2003 |
| 6437148 | Intermediates for (R)-3(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1, 2-a]imidazol-2-one A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1 ,2-a]imidazol-2-one (1): ##STR1## This compound is useful as an intermediate in the preparation of certain small molecules that are usefu... | 08/20/2002 |
| 6339082 | Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically acceptable acids and bases useful for treating loss of... | 01/15/2002 |
| 6326209 | Measurement and quantification of 17 ketosteroid-sulfates as a biomarker of biological age The present invention provides an improved method for using the measurement of total urinary 17 KS-S, referred to herein as the urinary Anabolic/Catabolic Index (ACI), as part of a biomarker for biological age.... | 12/04/2001 |
| 6277845 | Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates Compounds of the formula ##STR1## wherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss of bone matrix.... | 08/21/2001 |
| 6197750 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients su... | 03/06/2001 |
| 6121303 | Pharmacologically active catechol derivatives A compound of formula I ##STR1## wherein R1 is nitro, halogeno or cyano group and R2 is a group selected from ##STR2## wherein Y and Z are independently oxygen, sulfur or NR, wherein R is hydrogen, straight or branched... | 09/19/2000 |
| 6040311 | Integrin receptor antagonists The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .nu.댣, &... | 03/21/2000 |
| 5977377 | Process for producing N-alkylimidazole Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific surface area of 0.6 M2 /g or larger.... | 11/02/1999 |
| 5955617 | Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus The present invention provides novel compounds of the formulae I-VIII for the treatment of non-insulin dependent diabetes mellitus (NIDDM) and a new use of known compounds IX to X for this purpose.... | 09/21/1999 |
| 5932733 | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors The present invention discloses peptide aldehydes having a lactam group as part of the peptide backbone and having an original mimic group such as an amidinopiperidine or amidinophengyl tail. These compounds are potent and specific inhibitors of thrombin,... | 08/03/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5869481 | Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making Compounds having anticonsulive activity, of the formula 1 ##STR1## in which X is hydrogen, a C1-4 -alkyl, C1-4 alkoxy, trifluoromethyl, or halogen residue, R1 and R2 are independently of each other C1-... | 02/09/1999 |
| 5773646 | Meta-substituted phenylene derivatives The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting o... | 06/30/1998 |
| 5554633 | Substituted amines as tachykinin receptor antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H or C1-6 alkyl; R1 | 09/10/1996 |
| 5510344 | Acrylate fungicides Compounds of formula I ##STR1## wherein X is oxygen or sulphur, W is CH or N, m is 0 or 1, and either a) n is 1 and Q is a non-aromatic heterocyclic ring of 3 to 10 ring atoms, containing one to three hetero atoms selected from oxygen, sulphur and ... | 04/23/1996 |
| 5494927 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.... | 02/27/1996 |
| 5424450 | Angiotensin II receptor blocking imidazolinone derivatives Novel imidazolinone derivatives of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##... | 06/13/1995 |
| 5422360 | Maillard reaction inhibitor A novel Maillard reaction inhibitor containing at least one compound represented by formula (1) and the salts thereof; methods for producing the compounds of formula (1) and the salts thereof; a composition for inhibiting the Maillard reaction in living b... | 06/06/1995 |
| 5234917 | Substituted 5-(alkyl)carboxamide imidazoles Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and me... | 08/10/1993 |
| 5223525 | Pesticidal 1-arylimidazoles The invention describes novel 1-arylimidazoles of formula (I) ##STR1## wherein typically preferred substituents are: X is S(O)n R1, in which R1 is an alkyl group, preferably a methyl group, which is fully substituted ... | 06/29/1993 |
| 5183810 | Imidazole angiotensin II antagonists incorporating a substituted benzyl element Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##... | 02/02/1993 |
| 5177097 | Acyl amidine and acyl, guanidine substituted biphenyl derivatives Novel compounds are disclosed having the formula ##STR1## and wherein R1, R2 and R3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensi... | 01/05/1993 |
| 5143928 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.... | 09/01/1992 |
| 5143929 | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents The present invention is for selected novel compounds which are 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates, as well as pharmaceutical compositions and methods of use thereof. These compounds exhibit activity ... | 09/01/1992 |
| 5082943 | Novel imidazole derivatives Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R1 and R2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R1 and R2 are combined to form a heterocycli... | 01/21/1992 |
| 5030644 | Imidazole compounds and their use as transglutaminase inhibitors Imidazole compounds including imidazoles and imidazolium salts, and their use as transglutaminase inhibitors are disclosed.... | 07/09/1991 |
| 4996219 | Imidazolidine derivatives as immunosuppressives The present invention provides compounds of the general formulae: ##STR1## wherein R1 and R2, which can be the same or different, are hydrogen atoms or C1 -C5 -alkyl radicals, C3 -C5 -... | 02/26/1991 |
| 4973592 | 1,3-diazocycloalkenes as muscarinic receptor blocking agents New pharmacologically active heterocyclic derivatives as muscarinic receptor blocking agents, useful for the treatment of gastrointestinal disorders, of the following formula ##STR1## wherein the substituents are defined hereinbelow.... | 11/27/1990 |
| 4957936 | Glycocyamidine derivatives The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R1, R2 and R3, which may be the same or different, is hydrogen or a lower alkyl group, preferably ... | 09/18/1990 |
| 4892871 | Azido-substituted octopamine agonists and the use thereof to control invertebrate pests The invention is directed to azido-substituted octopamine agonists and the radiolabeled derivatives thereof. The invention also relates to past controlling compositions comprising the azido-substituted octopamine agonists of the invention. The invention a... | 01/09/1990 |
| 4873256 | Antiandrogenic 4-hydroxymethyl-2-imidazolidine-diones A compound in all possible racemic and optically active forms of the formula ##STR1## wherein .dbd.X is .dbd.O or imino having antiandrogenic activity and novel intermediates and processes for their preparations.... | 10/10/1989 |
