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| Number | Title | Issue Date |
| 7271188 | Imidazolidine derivatives The present invention provides a compound represented by formula (I): [Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, eac... | 09/18/2007 |
| 7244746 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 07/17/2007 |
| 7199146 | Imidazolidinedione analogs useful as anticoagulants and antithrombotics A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1, R2, R | 04/03/2007 |
| 7053112 | Imidazolidinedione analogs useful as anticoagulants and antithrombotics A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1 | 05/30/2006 |
| 6794517 | Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group fr... | 09/21/2004 |
| 6599926 | Heteroaryl-phenyl substituted factor Xa inhibitors The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of factor Xa.... | 07/29/2003 |
| 6531604 | Benzothiepine derivatives, their production and use The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/11/2003 |
| 6518293 | Anti-HIV imidazolone derivatives The invention is concerned with novel imidazolone derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human immunodeficiency virus reverse ... | 02/11/2003 |
| 6472415 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind ... | 10/29/2002 |
| 6294694 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 09/25/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6255327 | Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) ##STR1## wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for prep... | 07/03/2001 |
| 6242611 | Phenylimidazolidines containing nitrooxy or carbonyloxy groups A subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, substituted in particular by nitr... | 06/05/2001 |
| 6160001 | Halobenzimidazoles and their use as microbicides New halogenobezimidazoles of the formula ##STR1## in which A, R1, R2, R3, R4 and X have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for their preparat... | 12/12/2000 |
| 6107488 | Phenylimidazolidine preparation process A subject of the invention is a preparation process for the products of formula (I): ##STR1## in which R1 and R2 represent in particular hydrogen, cyano, halogen or amino,R3 represents in particular hydrogen or hydrox... | 08/22/2000 |
| 6034238 | Heterocyclic compounds, their preparation and their use as leucocyte adhesion inhibitors and VLA-4-antagonists Compounds of the formula I, ##STR1## in which B, E, W, Y, Z, R, R2, R2a, R2b, R3, g and h have the meanings indicated in the specifications. The compounds of the formula I are valuable pharmaceutical active... | 03/07/2000 |
| 5981556 | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5958958 | 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 09/28/1999 |
| 5939556 | Hydantoin compounds, salts thereof, processes for their preparation, and processes for preparing pharmaceutically active compounds comprising them The present invention relates to hydantoin derivatives of the formula I ##STR1## and which are intermediates for the preparation of pharmaceutical active compounds, their preparation and their use in the preparation of the active compounds.... | 08/17/1999 |
| 5750552 | Imidazoline derivative, possible tautomer thereof, and vulnerary including such derivative or tautomer An imidazoline derivative or possible tautomer thereof, represented by the formula (1), wherein n represents one of integers "1" through "4", and R1 and R2 represent hydrogen atom, lower alkyl, aryl, aralkyl group, or R1 a... | 05/12/1998 |
| 5733922 | Imidazole derivative, pharmaceutically acceptable salt thereof, and anti-ulcer drug including such derivative or salt An imidazole derivative represented by one of formulas (1), wherein R1, R2 represents hydrogen atom, lower alkyl, aryl, aralkyl group, or R1 and R2 cooperate to represent alkylene, alkylidene, arylalkylidene gro... | 03/31/1998 |
| 5731311 | N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R1 is --C(NH)NH2, --C(NH)N(H)OR11, --C(NH)N(H)C(O)R9, or --C(NH)N(H)C(O)OR11 ; R2... | 03/24/1998 |
| 5656651 | Androgenic directed compositions Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targe... | 08/12/1997 |
| 5650428 | Arylsulfonamide derivative and pharmaceutical compositions and use thereof An arylsulfonamide derivative of the formula (I): ##STR1## wherein R1 is unsubstituted phenyl or naphthyl, or phenyl substituted by 1 to 3 same or different substituents selected from the group consisting of halogen, alkyl, nitro and alkox... | 07/22/1997 |
| 5627201 | Phenylimidazolidines having antiandrogenic activity A compound of the formula ##STR1## wherein R1 is selected from the group consisting of --CN, --NO2 and halogen, R2 is --CF3 or halogen, --A--B-- is selected from the group consisting of ##STR2## X... | 05/06/1997 |
| 5608076 | Method of preparing amionoakylhydantoins and aminoalkyl-alpha-amino acids The invention relates to a method of preparing 5-(aminoalkyl)-hydantoins with basic side chain in which the protection of the amino function in the side chain is necessary during the formation of the hydantoin requires minimal expense.... | 03/04/1997 |
| 5589497 | Phenylimidazolidines A compound selected from the group consisting of compounds of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of --CN, --NO2, halogen, --CF3, free carboxy, salifie... | 12/31/1996 |
| 5565575 | Method for the production of 5-cyclohexylmethylhydantoin derivatives 5-Cyclohexylmethylhydantoin derivatives may be conveniently prepared by reducing, in the presence of a metal catalyst, a 5-(3-cyclohexene-1-yl)melthylenehydantoin derivative which is obtained by the condensation of a hydantoin derivative and a 3-cycl... | 10/15/1996 |
| 5411981 | Phenylimidazolidines having antiandrogenic activity A compound of the formula ##STR1## wherein R1 is --CN, --NO2 or halogen, R2 is --CF3 or halogen, --A-B-- is of ##STR2## X is --O-- or --S--, R3 is hydrogen, alkyl, alkenyl or alkynyl of up ... | 05/02/1995 |
| 5385985 | Cyclic urea derivative Disclosed is cyclic urea derivatives represented by the following formula (A): ##STR1## wherein n is an integer of 0 or 1; m is an integer of 1 to 15; X is oxygen, sulfur or --NR1 -- (R1 is hydrogen or an alkyl group having... | 01/31/1995 |
| 5358946 | Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis This invention relates to imidazoles, namely, heterocycle-substituted amides, carbamates and ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, and their use as antihypercholesterolemic and/or... | 10/25/1994 |
| 5346913 | N-iodopropargyl hydantoin compounds, compositions, preparation, and use as antimicrobial agents N-Iodopropargyl hydantoin compounds, methods of preparing, compositions comprising, and methods of use as antimicrobials and antifungal agents in a variety of applications.... | 09/13/1994 |
| 5298659 | Method for the preparation of azomethines Azomethines can be prepared by the condensation of cycloalkanones and anilines in the presence of acid homogeneous catalysts while the water of reaction is removed azeotropically, the condensation being carried out in a continuous reaction in a column-lik... | 03/29/1994 |
| 5284948 | Drug hapten analogues for immunoassays The invention is directed to new drug hapten analogues comprising: (A) an active ester group; (B) a drug hapten nucleus selected from a hydantoin nucleus or a barbiturate nucleus and (C) a linking chain linking the 3-position of the drug hapten nucleus to the ... | 02/08/1994 |
| 5223525 | Pesticidal 1-arylimidazoles The invention describes novel 1-arylimidazoles of formula (I) ##STR1## wherein typically preferred substituents are: X is S(O)n R1, in which R1 is an alkyl group, preferably a methyl group, which is fully substituted ... | 06/29/1993 |
| 4868061 | Olefinic aryl oxime derivatives of hydantoins This invention relates to new compounds of the formula: ##STR1## where each of R1, R2, R3, R4 and R5 has zero to 10 C atoms, and no acetylenic unsaturation; each of R1, R2 and ... | 09/19/1989 |
| 4859228 | Novel 5-aminomethylene-2,4-imidazolidinediones and 5-aminomethylene-2-thionoimidazolidine-4-ones Compounds of the formula ##STR1## wherein R is alkyl, phenyl, substituted phenyl, alkylsulfonyl, alkoxy, halo or haloalkyl; R1 is hydrogen, alkyl, phenyl, or halo substituted phenyl; R2 is hydrogen or alkyl; R3 is ... | 08/22/1989 |
| 4833252 | Herbicidal sulfonylureas Substituted N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts thereof with amines, alkali metal bases or alkaline earth metal bases, or with quaternary ammonium bases, have good ... | 05/23/1989 |
| 4792556 | Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 and R2 are the same and are lower alkoxy or optionally substituted phenoxy, R3 is lower alkyl, lower alkoxy... | 12/20/1988 |
| 4705864 | Aryl oxime derivatives of hydantoins A compound of the formula ##STR1## useful as an ultraviolet light absorber where each of R and R' has zero to 10 C atoms and no ethylenic or acetylenic unsaturation; R is H or hydrocarbyl; R' is H, hydrocarbyl, or hydrocarbyl substituted with hy... | 11/10/1987 |
