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| Number | Title | Issue Date |
| 7745637 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 06/29/2010 |
| 7199146 | Imidazolidinedione analogs useful as anticoagulants and antithrombotics A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1, R2, R | 04/03/2007 |
| 7173057 | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 02/06/2007 |
| 7102013 | Methods of making amidino compounds useful as nitric oxide synthase inhibitors Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: | 09/05/2006 |
| 7053112 | Imidazolidinedione analogs useful as anticoagulants and antithrombotics A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1 | 05/30/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6962937 | Imidazolidine derivatives, their preparation and their use The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings given herein. ... | 11/08/2005 |
| 6881747 | Small molecules for inhibition of function and drug delivery to leukocytes The present invention provides a compound and a method of making a compound according to the following formula: where R1 is an alkyl group having 1 to 12 carbons; R2 is a urea group; R3 | 04/19/2005 |
| 6875438 | Preparations for topical administration of substances having antiandrogenic activity A preparation comprising at least one form of lipid nanoparticles or a nanoemulsion comprising at least one compound of the formula I and/or one stereoisomeric form of the compound of the formula I and/or one physiolog... | 04/05/2005 |
| 6806369 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 10/19/2004 |
| 6794517 | Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group fr... | 09/21/2004 |
| 6696475 | Substituted phenyl derivatives, their preparation and use The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.... | 02/24/2004 |
| 6680333 | Imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to novel imidazolidine derivatives of formula I, ##STR1## wherein A, E, Z, R1, R2, R3, R4 and R5 have the meanings indicated in the claims. The compounds of formula I are... | 01/20/2004 |
| 6667334 | Imidazolidine derivatives, the production thereof, their use and pharmaceutical preparations containing the same The present invention relates to imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable... | 12/23/2003 |
| 6569876 | Method and structure for inhibiting activity of serine elastases The present invention is directed to novel inhibitors and methods for inhibiting serine elastases. These compounds and methods achieve a novel approach to enzyme inhibition; namely, balanced inhibition of a plurality of serine elastases. Balanced inhibiti... | 05/27/2003 |
| 6566384 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.... | 05/20/2003 |
| 6562853 | 2,5-dioxo-3-(2-propynyl)imidazolidin-1-ylmethyl 2,2-dimethyl-3-(alenyl) cyclopropane carboxylate compounds and pesticidal methods and compositions utilizing the same The present invention provides ester compounds, methods of controlling a pest and uses of the ester compounds. The ester compounds are encompassed by formula (1): ##STR1## wherein R represents a C1 to C3 alkyl group. The methods of controlling a pest... | 05/13/2003 |
| 6521654 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them Substituted imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active com... | 02/18/2003 |
| 6462063 | C-proteinase inhibitors The present invention relates to a novel class of N,N'-di substituted hydantoin hydroxamates capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatm... | 10/08/2002 |
| 6423712 | 2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to imidazolidine compounds of the formula I, ##STR1## The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, fo... | 07/23/2002 |
| 6355664 | Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the following structural formulas: ##STR1## ##STR2##... | 03/12/2002 |
| 6344473 | Imidazoles useful as nitric oxide synthase inhibitors 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 02/05/2002 |
| 6297261 | Substituted phenyl derivatives, their preparation and use A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##... | 10/02/2001 |
| 6294573 | Reverse hydroxamate inhibitors of matrix metalloproteinases Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.... | 09/25/2001 |
| 6294562 | Salts of ethyl 3-(2-(4-(4-amino-imino-methyl)phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl )acetylamino)-3-phenylpropionate The present invention relates to ethyl 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxoimidazolidin-1-y l)acetylamino)-3-phenylpropionate salts of the formula I, ##STR1## in which HM is maleic acid, and to their physiologically tolerated salts, ... | 09/25/2001 |
| 6288063 | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)x A--B--D--E--G whe... | 09/11/2001 |
| 6277827 | Single morphic forms of metalloproteinase inhibitors A single morphic form of a compound selected from 2S-[4-(2,5-dioxopyrrolidin-1-yl)-2S-mercaptobutyrylamino]-4-methylpentanoi c acid (2,2-dimethyl-1S-methylcarbamoylpropyl)amide and 2S-[2S-mercapto-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butyrylamino ... | 08/21/2001 |
| 6235928 | ଲ-sulfonyl hydroxamic acids The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof. Such compounds may be incorporated into pharmaceutical compositions which can inhibit various enzymes from the matrix metalloproteinase family. ##... | 05/22/2001 |
| 6235786 | Reverse hydroxamate inhibitors of matrix metalloproteinases Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.... | 05/22/2001 |
| 6222039 | Process for the preparation of chiral lactones The present invention relates to a process for the preparation of compounds of formula I ##STR1## wherein R1 and R2 are as defined in the specification as well as to the novel intermediates obtained by said process.... | 04/24/2001 |
| 6187924 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Compounds of formula (I) ##STR1## are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.... | 02/13/2001 |
| 6172057 | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/09/2001 |
| 6169103 | Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A,... | 01/02/2001 |
| 6018053 | Process for the preparation of chiral, nonracemic (4-aryl-2,5-dioxoimidazolidin-1-yl) acetic acids The present invention relates to a process for the preparation of chiral, nonracemic compounds of the formula I ##STR1## in which R1 and R2 have the meanings indicated in claim 1 and which are useful intermediates for the prepar... | 01/25/2000 |
| 5998447 | Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belon... | 12/07/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5912261 | Carboxyalkyl heterocyclic derivatives Carboxyalkyl heterocyclic derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy... | 06/15/1999 |
| 5880289 | Crystallization method Disclosed is a method of crystallizing coupler crystals, the method comprising the steps of dissolving crude crystals of a coupler in a first solvent having a first solubility parameter to obtain a coupler solution; and adding to the solution a second sol... | 03/09/1999 |
| 5877324 | 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives The compound of formula I: ##STR1## wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R3 | 03/02/1999 |
| 5859190 | Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.... | 01/12/1999 |
