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| Number | Title | Issue Date |
| 7544812 | Peroxisome proliferator activated receptor agonists The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4-alk... | 06/09/2009 |
| 7354933 | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use... | 04/08/2008 |
| 6900213 | Bisaryl derivatives having FSH modulatory activity The invention relates to bisaryl derivatives of the formula I, wherein (R,R) is selected from (H,H), O, (H,CH3), (H,OH) and (H,CN); Ar is substituted phenyl and A is a group of formula II, III, IV ... | 05/31/2005 |
| 6794517 | Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group fr... | 09/21/2004 |
| 6452010 | Process for the preparation of hydroxamic acid derivatives The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.... | 09/17/2002 |
| 6350881 | Process for the preparation of 5-methoxy-4-(methylthioalkyl) 1, 3-bis(phenylmethyl)-2-imidazolidone This invention provides a process for the preparation of 5-methoxy-4-(methylthioalkyl)-1,3-bis(phenylmethyl)-2-imidazolidone having general formula (2a-d) ##STR1## [wherein R.dbd.--CH2 COCH2 CH2 CH2 COOMe (2a); ... | 02/26/2002 |
| 6300503 | Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using th... | 10/09/2001 |
| 6294694 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 09/25/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6242611 | Phenylimidazolidines containing nitrooxy or carbonyloxy groups A subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, substituted in particular by nitr... | 06/05/2001 |
| 6191282 | Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparation and their use 5-Membered ring heterocycle of the formula I, ##STR1## in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparat... | 02/20/2001 |
| 6172238 | Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo -1-imidazolidinyl)ethyl]propionyl]piperidine A process manufactures of a compound of formula: ##STR1## and unique intermediates.... | 01/09/2001 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6087509 | 1-Imidazolidinyl-phenyls A particular subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, optionally s... | 07/11/2000 |
| 6054591 | Lymph-absorbable aryl substituted imidazole derivatives A compound of the formula (I): ##STR1## salt thereof, or hydrate thereof which can effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high concentration is provided.... | 04/25/2000 |
| 6034238 | Heterocyclic compounds, their preparation and their use as leucocyte adhesion inhibitors and VLA-4-antagonists Compounds of the formula I, ##STR1## in which B, E, W, Y, Z, R, R2, R2a, R2b, R3, g and h have the meanings indicated in the specifications. The compounds of the formula I are valuable pharmaceutical active... | 03/07/2000 |
| 6031103 | Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine A process manufactures of a compound of formula: ##STR1## and unique intermediates.... | 02/29/2000 |
| 5981492 | Substituted 5-membered ring heterocycles, their preparation and their use The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet ... | 11/09/1999 |
| 5929249 | Substituted imidazolyl-alkyethio-aldanoic acids Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 07/27/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5912261 | Carboxyalkyl heterocyclic derivatives Carboxyalkyl heterocyclic derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy... | 06/15/1999 |
| 5877324 | 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives The compound of formula I: ##STR1## wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R3 | 03/02/1999 |
| 5783707 | 2-thioxo-imidazolidin-4-one derivatives The compound of formula I ##STR1## in which R1 is alkyl; and R is alkyl, naphthyl, benzhydryl, fluorophenylmethyl, phenethyl, 1-(fluorophenyl)ethyl, 5-chloro-2-methoxyphenyl, trifluoromethoxyphenyl, trifluoromethylphenyl, methylsulfan... | 07/21/1998 |
| 5728842 | Substituted imidazolyl-alkylthio-alkanoic acids Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 03/17/1998 |
| 5717109 | Excitatory amino acid receptor antagonists The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as anta... | 02/10/1998 |
| 5691335 | Imidazolidine derivative and use thereof The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, ... | 11/25/1997 |
| 5670646 | Monomeric and polymeric cyclic amine and-halamine compounds Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are... | 09/23/1997 |
| 5663363 | 2-thioxo-imidazolidin-4-one derivatives The compound of formula I ##STR1## in which R is alkynyl; and X and Y are, independently, alkyl, halo, perfluoralkyl, perfluoralkoxy, or, taken together, X and Y are ortho substituted trimethylene or tetramethylene are useful for increasing blood ... | 09/02/1997 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5616722 | Antimicrobial solution of formaldehyde substituted hydantoin and process for preparation A method of preparing a formaldehyde substituted hydantoin in the form of a liquid antimicrobial preservative solution is disclosed. The inventive solution prepared by the disclosed method comprises a condensation product of a 5,5-disubstituted hydantoin ... | 04/01/1997 |
| 5614541 | Pharmacologically active catechol derivatives New catechol derivatives and pharmaceutically acceptable salts and esters thereof useful as pharmaceutical antioxidants are disclosed. Cellular damage by oxygen derived radicals is a significant factor in heart disease, rheumatoid arthritis, cancer, infla... | 03/25/1997 |
| 5589497 | Phenylimidazolidines A compound selected from the group consisting of compounds of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of --CN, --NO2, halogen, --CF3, free carboxy, salifie... | 12/31/1996 |
| 5571940 | Method for making conjugate moieties capable of chelating paramagnetic metals and designed for coupling with a factor responsive to specific cellular marker sites In this method, one attaches one or more chelatant molecules to a mono- or polyamino intermediate compound I which is temporarily immobilized on a solid phase by a splittable bond. Thereafter, said bond is split to release the desired conjugate moiety, wh... | 11/05/1996 |
| 5565575 | Method for the production of 5-cyclohexylmethylhydantoin derivatives 5-Cyclohexylmethylhydantoin derivatives may be conveniently prepared by reducing, in the presence of a metal catalyst, a 5-(3-cyclohexene-1-yl)melthylenehydantoin derivative which is obtained by the condensation of a hydantoin derivative and a 3-cycl... | 10/15/1996 |
| 5494927 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.... | 02/27/1996 |
| 5459148 | Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R1 is alkyl, alkenyl, cycloalkyl or a group of formula R4 --Y--R5 --, where: R4 is hydrogen, alkyl, or ... | 10/17/1995 |
| 5436336 | Preparation of isocyanurate- and/or uretidone-containing polysiocyanates having a reduced color index and improved shelf life, and products prepared by this method Isocyanurate- and/or uretidone-containing polyisocyanates having a reduced color index and improved shelf life are prepared by conventional catalytic oligomerization of aliphatic and/or cycloaliphatic diisocyanates and treatment of the oligomerization pro... | 07/25/1995 |
| 5414114 | Method for making conjugate moieties capable of chelating paramagnetic metals and designed for coupling with a factor responsive to specific cellular marker sites In this method, one attaches one or more chelatant molecules to a mono- or polyamino intermediate compound which is temporarily immobilized on a solid phase by a splittable bond. Thereafter, said bond is split to release the desired conjugate moiety, wher... | 05/09/1995 |
| 5405862 | Low free formaldehyde methylolhydantoin compositions Compositions of dimethyloldimethylhydantoin, monomethyloldimethylhydantoin, and dimethylhydantoin having less than 0.1% by weight of free formaldehyde based upon 100% by weight of total composition; and wherein the weight ratio of dimethyloldimethylhydant... | 04/11/1995 |
| 5362733 | Pharmacologically active catechol derivatives Compounds of formula(I) ##STR1## wherein R1 is nitro, halo, cyano and R2 is a group selected from ##STR2## wherein Y is oxygen or sulfur; X1 is NR wherein R is hydrogen, C1-8 alkyl or phenyl and pharma... | 11/08/1994 |
