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| Number | Title | Issue Date |
| 7354940 | 2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12 The invention provides compounds of formula (I) in which L, X, Y, Z1, Z2, R1, R2, R3 and G2 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions... | 04/08/2008 |
| 7256208 | Monocyclic -Aryl hydantoin modulators of androgen receptor function The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a... | 08/14/2007 |
| 7202366 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 04/10/2007 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7014781 | Methods and articles for maintaining hydantoinylated polymers in a biocidally active state A composition and the method for sustaining the biocidal activity of chlorinated polystyrene hydantoin beads. The method comprises supplying a continuous low level halogen concentration to the chlorinated polystyrene hydantoin beads in the water to be treated that f... | 03/21/2006 |
| 6919365 | Imidazolidinedione derivatives and use thereof as drugs The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R | 07/19/2005 |
| 6919364 | Microbiological control in animal processing Fecal bacterial contamination in an animal is reduced by providing it with drinking water containing a microbiocidally-effective amount of halogen-based microbiocide resulting from mixing with water (A) a product formed in water from (i) bromine, chlorine, or bromin... | 07/19/2005 |
| 6908636 | Microbiological control in poultry processing In the processing of poultry, equipment, instruments, apparatus and/or water used in such processing, and/or carcasses and/or parts of poultry resulting from the processing of poultry, are disinfected with aqueous solutions of certain halogen-based microbiocides, es... | 06/21/2005 |
| 6797827 | Process for the preparation of alpha-amino acids by hydrolysis of hydantoins at elevated pressure and elevated temperature A process for the preparation of α-amino acids by hydrolysis of hydantoins in the presence of water and at least one metallic oxide under conditions such that all the starting materials are completely dissolved in the water as a result of high pressure and high tem... | 09/28/2004 |
| 6790953 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 09/14/2004 |
| 6720317 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 04/13/2004 |
| 6441190 | Process of the preparation of chiral nicotinic, quinolinic or benzoic acid imidazolinone herbicides There is provided a stereospecific process for the preparation of essentially enantiomerically pure imidazolinone herbicides having the R-configuration via (R) 2-amino-2,3-dimethylbutyronitrile.... | 08/27/2002 |
| 6331633 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In co... | 12/18/2001 |
| 6294694 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 09/25/2001 |
| 6281363 | Cyclic hydrazine derivatives Hydrazine derivatives and their pharmaceutically acceptable salts useful for the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumors, cachexia, cardiovascular disease, fever, hemorrhage, and sepsis.... | 08/28/2001 |
| 6191282 | Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparation and their use 5-Membered ring heterocycle of the formula I, ##STR1## in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparat... | 02/20/2001 |
| 6127548 | Process for the preparation of formylimidazoles A process for the preparation of formylimidazoles of the general formula: or its tautomers, in which R1 is hydrogen or alkyl, and R2 is hydrogen, halogen or alkyl. In a first stage, an imidazole derivative of the general formula: ... | 10/03/2000 |
| 6066662 | Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. The... | 05/23/2000 |
| 5981492 | Substituted 5-membered ring heterocycles, their preparation and their use The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet ... | 11/09/1999 |
| 5922751 | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-... | 07/13/1999 |
| 5847123 | Imide derivatives for inhibiting the production of interleukin-1ଲ and the production of tumor necrosis factor Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-ଲ and also the production of Tumor Necrosis Factor . These imide compounds are u... | 12/08/1998 |
| 5808089 | Substituted heterocyclic amine monomers Substituted 5- to 6-membered heterocyclic amine monomers are provided. Methods of making the same, wherein a polymer is heated under vacuum to crack it into monomeric units and the aceto moiety is converted to a selected moiety, are provided. Monomers inc... | 09/15/1998 |
| 5750553 | Optionally substituted phenylimidazolidines, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula ##STR1## wherein Y is --O--, Z2 is --CF3, Z1 is --CN or --NO2, X is --O-- or --S--, R3 is hydrogen or alk... | 05/12/1998 |
| 5731311 | N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R1 is --C(NH)NH2, --C(NH)N(H)OR11, --C(NH)N(H)C(O)R9, or --C(NH)N(H)C(O)OR11 ; R2... | 03/24/1998 |
| 5703104 | Cyclic amides and derivatives thereof Compounds, topical compositions and methods useful for preventing the penetration of toxic chemicals through the skin of a mammal are disclosed. The compounds of the invention provide an enhanced barrier for the skin of a mammal to further inhibit or decrease ... | 12/30/1997 |
| 5691335 | Imidazolidine derivative and use thereof The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, ... | 11/25/1997 |
| 5681838 | Substituted amino compounds, their preparation and their use as inhibitors of thrombocyte-aggregation The present invention relates to novel substituted amino compounds of the formula I: R1 -(A)a -(B)b -(D)c -(CH2)m -N(R2)-(CH2)n -R3 as defined in the ... | 10/28/1997 |
| 5681843 | Parabanic acid derivatives Parabanic acid derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy, diabetic ... | 10/28/1997 |
| 5670647 | Method for recovering optically pure amino acid derivatives A method for recovering an optically pure amino acid derivative from a waste liquor collected after a coupling reaction in peptide synthesis, comprising the steps of (a) adding into the waste liquor, in which an uncoupled amino acid derivative or an uncou... | 09/23/1997 |
| 5633389 | Thermoreversible coating and a process for its manufacture The invention relates to a thermoreversible process for the preparation of a hydantoin comprisng (a) reacting an unsaturated polyester with a monofunctional amine to yield a poly(ester aspartate), and (b) reacting said poly(ester aspartate) with an isocyanate ... | 05/27/1997 |
| 5627201 | Phenylimidazolidines having antiandrogenic activity A compound of the formula ##STR1## wherein R1 is selected from the group consisting of --CN, --NO2 and halogen, R2 is --CF3 or halogen, --A--B-- is selected from the group consisting of ##STR2## X... | 05/06/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |
| 5480884 | Compounds having a guanidine structure Compounds are provided useful for promoting growth, repair and regeneration of a neuronal axon and for treating neuropathies and myopathies having formula I ##STR1## wherein R2, R3 and R4 together with the nitrogen at... | 01/02/1996 |
| 5440046 | Substituted imidazoles The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furth... | 08/08/1995 |
| 5411981 | Phenylimidazolidines having antiandrogenic activity A compound of the formula ##STR1## wherein R1 is --CN, --NO2 or halogen, R2 is --CF3 or halogen, --A-B-- is of ##STR2## X is --O-- or --S--, R3 is hydrogen, alkyl, alkenyl or alkynyl of up ... | 05/02/1995 |
| 5385985 | Cyclic urea derivative Disclosed is cyclic urea derivatives represented by the following formula (A): ##STR1## wherein n is an integer of 0 or 1; m is an integer of 1 to 15; X is oxygen, sulfur or --NR1 -- (R1 is hydrogen or an alkyl group having... | 01/31/1995 |
| 5378842 | Imidazolium hardeners for proteinaceous materials An improved imidazolium hardener is described. These novel hardeners are specifically advantageous for hardening, or crosslinking, a hydrophilic colloid in a photographic element. The advance in the art is realized in A hardening agent chosen from the set... | 01/03/1995 |
| 5342958 | Organic compounds derived from urea or thiourea Compounds of the formula ##STR1## wherein A is a hydrogen atoms, a halogen atom, a methyl group, or a methoxy group; B is a hydrogen atom, a halogen atom, a methyl group, or a methoxy group, with the proviso that A and B ar not both a hydrogen atom; ... | 08/30/1994 |
| 5329012 | Bis(acyloxmethyl)imidazole compounds This invention relates to new bis(acyloxymethyl)imidazole derivatives; to compositions comprising these derivatives; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer, particularly solid tumor cancer,... | 07/12/1994 |
| 5284948 | Drug hapten analogues for immunoassays The invention is directed to new drug hapten analogues comprising: (A) an active ester group; (B) a drug hapten nucleus selected from a hydantoin nucleus or a barbiturate nucleus and (C) a linking chain linking the 3-position of the drug hapten nucleus to the ... | 02/08/1994 |
