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| Number | Title | Issue Date |
| 7652148 | Electrophilic aromatic substitution with diacyl imidazolium Polyimidazoline molecules and methods of making them are provided. A representative polyimidazoline has a structure: wherein: X is trifluoroacetyl or trifluoromethanesulfonyl; R | 01/26/2010 |
| 7183277 | Carboxylic acid amides Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophyla... | 02/27/2007 |
| 7176227 | Amine compounds and use thereof Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: | 02/13/2007 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6906199 | Process for preparing distamycin derivatives It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative of formula | 06/14/2005 |
| 6784293 | Process for making Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils The present invention provides a process for the efficient assembly of Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils via a one-pot solution phase or solid phase synthesis from readily available starting materials. ... | 08/31/2004 |
| 6753316 | Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring of the polyetherocyclic chain, from N and CH; R1 | 06/22/2004 |
| 6693200 | 2-(substituted-phenyl)amino-imidazoline derivatives This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: ##STR1## where: R1 is a group represented by formula (A), (B) or (C); ##STR2## and other substituents as defined in the specifi... | 02/17/2004 |
| 6683189 | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise ... | 01/27/2004 |
| 6673780 | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucos... | 01/06/2004 |
| 6673940 | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular un... | 01/06/2004 |
| 6627758 | Compositions and methods for hydration of terminal alkynes Compositions and methods are described for hydrating terminal alkynes catalytically in anti-Markovnikov fashion. The compositions comprise a transition metal complex including at least one organic ligand having at least two heteroatoms, wherein the hetero... | 09/30/2003 |
| 6620529 | Materials for light emitting devices and light emitting devices using the same A compound represented by general formula (113): ##STR1## wherein R1 and R2 each represents a hydrogen atom, an aliphatic hydrocarbon group, an aryl group or a heterocylic group; Z1 represents an atomic group necessary to ... | 09/16/2003 |
| 6593357 | Pyrazole compositions useful as inhibitors of ERK Described herein are compounds that are useful as protein kinase inhibitors having the formula: ##STR1## where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviate... | 07/15/2003 |
| 6545162 | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise ... | 04/08/2003 |
| 6482954 | Imidazole containing compounds having relatively low hydrogen content and relatively high nitrogen content and polymers and copolymers formed therefrom In one embodiment, the invention provides a polymer comprising imidazole ring units having nitrogen at the 1 and 3 positions of the ring; a carbon at each of the 2, 4 and 5 positions of the ring; and radical substituents G1 and G2 carried at the 4 and 5 p... | 11/19/2002 |
| 6472537 | Polyamides for binding in the minor groove of double stranded DNA The invention encompasses improved polyamides for binding to specific nucleotide sequences in the minor groove of double stranded DNA. The 3-hydroxy-N-methylpyrrole/N-methylpyrrole carboxamide pair specifically recognizes the T.multidot.A base pair, while... | 10/29/2002 |
| 6448286 | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.... | 09/10/2002 |
| 6437121 | Cationic lipids The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two substituted histidine residues, o... | 08/20/2002 |
| 6416770 | Use of heterocyclic quaternary polyammonium polymers as protective agent for keratin fibres and cosmetic compositions The invention relates to the use of heterocyclic quaternary polyammonium polymers as protective agent for keratin fibres, to cosmetic compositions using them and to method for treating hair with the aid of these polymers.... | 07/09/2002 |
| 6271237 | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho ... | 08/07/2001 |
| 6211186 | Enzyme Inhibitors The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in heal... | 04/03/2001 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6096899 | Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom In one embodiment, the invention provides a polymer comprising imidazole ring units having nitrogen at the 1 and 3 positions of the ring; a carbon at each of the 2, 4 and 5 positions of the ring; and radical substituents G1 and G2 carried at the 4 and 5 p... | 08/01/2000 |
| 6090947 | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise ... | 07/18/2000 |
| 6080769 | Imidazolidin-4-one derivatives useful as anticancer agents The present invention relates to compounds of formula 1 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein Z, R, R3 and R4 are as defined herein. The invention also relates to pharmaceutical composit... | 06/27/2000 |
| 6034238 | Heterocyclic compounds, their preparation and their use as leucocyte adhesion inhibitors and VLA-4-antagonists Compounds of the formula I, ##STR1## in which B, E, W, Y, Z, R, R2, R2a, R2b, R3, g and h have the meanings indicated in the specifications. The compounds of the formula I are valuable pharmaceutical active... | 03/07/2000 |
| 6008372 | Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase Substituted histidine compounds of formula (I) are described as well as methods for the preparation and pharamaceutical compositions of same, which are useful as inhibitors of protein famesyltransferase and for the treatment of proliferative diseases incl... | 12/28/1999 |
| 5935997 | O-thiocarbamoyl-aminoalkanol compounds, their pharmaceutically useful salts and process for preparing the same The present invention relates to O-thiocarbamoyl-aminoalkanol compound represented by the following structural formula (VI), (VIII) and (IX) which are a racemic or enantiomerically enriched and pharmaceulically acceptable salts thereof to treat diseases o... | 08/10/1999 |
| 5840721 | Imidazole derivatives as MDR modulators The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic agents.... | 11/24/1998 |
| 5763469 | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors The present invention relates to substituted cyclic ureas and analogs thereof of formula (I): ##STR1## wherein, T is selected from: --N(R22)C(.dbd.Z)N(R23)--; --N(R22)C(.dbd.Z)C(.dbd.Z)N(R23)--; --N(R | 06/09/1998 |
| 5756528 | Inhibitors of farnesyl-protein transferase The present invention comprises low molecular weight peptidyl compounds that inhibit the farnesyl-protein transferase. Furthermore, these compounds differ from the mono- or dipeptidyl analogs previously described as inhibitors of farnesyl-protein transfer... | 05/26/1998 |
| 5733882 | Retroviral protease inhibitors The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.... | 03/31/1998 |
| 5728879 | Bisguanidine salts and a method for releasing a base using the same salts A bisguanidine salt selected from the group consisting of a 4-(phenylsulfonyl)phenylsulfonylacetic acid salt of N,N'-bis(1,3-diethylguanyl)ethylenediamine, a 4-(phenylsulfonyl)phenylsulfonylacetic acid salt of N,N'-bis(1,3-diisopropylguanyl)ethylened... | 03/17/1998 |
| 5728839 | Metal complexes with heterocycles carbenes A complex of the formula La Mb Xc !n (A)n I as described in the application useful as homogenous catalysts.... | 03/17/1998 |
| 5710171 | Bisphenyl inhibitors of farnesyl-protein transferase The present invention comprises peptidomimetic compounds which comprise a suitably substituted aminoalkylbenzene and analine analogs, further substituted with a second phenyl ring attached via a bond, a heteroatom linker or an aliphatic linker. The instan... | 01/20/1998 |
| 5698563 | Bis-hydrazones! The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of the formula ##STR1## capable of inhibiting the format... | 12/16/1997 |
| 5646147 | Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention relates to compounds of the formula ##STR1## in which Ar... | 07/08/1997 |
| 5618793 | Nikkomycin analogs Compounds of the formula ##STR1## wherein R3, R4, J, K, Z, and Het are as set forth herein are described. The compounds of formula I are useful as agents in the treatment of fungal infections.... | 04/08/1997 |
| 5610297 | Peptides ketoamides A novel class of peptide -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M | 03/11/1997 |
