Class 548/310.1 - Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 197
Last issue date: 08/23/2011

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Number	Title	Issue Date
8003806	Integrin antagonists useful as anticancer agents The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The inventio...	08/23/2011
7960562	Propane-1,3-dione derivative or salt thereof It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by...	06/14/2011
7943781	Process for preparing telmisartan A process comprising cyclizing 3-amino-4-butyramido-5-methylbenzoic acid to form 2-n-propyl-4-methyl-benzimidazole-6-carboxylic acid. ...	05/17/2011
7939672	Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion...	05/10/2011
7732618	Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit th...	06/08/2010
7612211	Benzimidazole TRPV1 inhibitors The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them. ...	11/03/2009
7456293	Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1; or pharmaceutically acceptable salts thereof. The present invention...	11/25/2008
7348438	Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ...	03/25/2008
7309716	Benzimidazoles useful as modulators of ion channels The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The inventi...	12/18/2007
7271261	Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ...	09/18/2007
7173053	N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R1 represents hydrogen, methyl or triflur...	02/06/2007
7144909	Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subcllinical hyperthyrodis...	12/05/2006
7129258	Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X a...	10/31/2006
7115645	1,2 diarylbenzimidazoles and their pharmaceutical use Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation a...	10/03/2006
7030139	Compounds Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain	04/18/2006
6919331	Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatm...	07/19/2005
6919366	Benzimidazole derivatives as modulators of IgE This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases where IgE is pathogenic. ...	07/19/2005
6900218	Pyruvate derivatives Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes...	05/31/2005
6888005	2-phenylbenzimidazole-5-sulphonic acid from isolated 3,4-diaminobenzenesulphonic acid and use thereof in cosmetic preparations A process for the preparation of 2-phenylbenzimidazole-5-sulphonic acid, characterized in that 3,4-diaminobenzenesulphonic acid is reacted at a pH between 4 and 7 in aqueous solution with 0.9 to 1.5 mol of benzaldehyde per mole of 3,4-diaminobenzenesulphonic acid an...	05/03/2005
6869950	Benzimidazole derivatives The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof: wherein R1 represents a lower alkyl group or a lower alkyloxy-lower alkyl group; R2 r...	03/22/2005
6855714	1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the produ...	02/15/2005
6780992	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compo...	08/24/2004
6603014	Use of cyclic enamines as light protection agents The use of compounds of the formula I ##STR1## in which R1 and R2 are identical or different, electron-withdrawing radicals chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl and optionall...	08/05/2003
6596751	଱-substituted carboxylic acid derivatives The ଱-substituted carboxylic acid derivatives having the formula (I): ##STR1## wherein R1 is an alkyl group, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., A is .dbd.CH-group, etc., B is an oxygen at...	07/22/2003
6482859	Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsu...	11/19/2002
6465505	Benzyl-substituted benzimidazoles The present invention relates to benzimidazole derivatives of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be use...	10/15/2002
6465484	Angiogenesis inhibitors The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tryrosine kinase-dependent diseases/conditions such ...	10/15/2002
6444694	Styryl benzimidazole derivatives Disclosed herein are compounds of the formula: ##STR1## wherein R is phenyl or substituted phenyl; or R is furyl, pyridyl or quinolinyl; R1 and R2 are hydrogen, halogen, alkyl, alkoxy, nitro, carboxyl, alkoxy-carbonyl or aryloxycarbonyl; ...	09/03/2002
6440401	2-phenyl-benzimidazolesulfonic acids as UV-B filters Disclosed is a 2-phenyl-benzimidazolesulfonic acid according to the formula ##STR1## in which n is 0, 1 or 2 and m is 2 or 3, R1, R2, R3, R4 and R5, are each a radical such as H, C1-8 -alkyl, C1-8 -alkoxy, hydroxyl, sulfate, nitro, F, Cl,...	08/27/2002
6410743	Tetrahydronaphtalene derivatives and their use Tetrahydronaphatalene derivatives, and compositions comprising the compounds. The tetrahydronaphatalene derivates are useful in inhibiting a rise in intracellular calcium mediated by an influx through T-type calcium channels, and are thus useful for treat...	06/25/2002
6387927	Epothilone derivatives and their use as antitumor agents The invention relates to anti-tumour-effective compounds of formula (I), wherein the radicals have the meanings given in the description. ##STR1##...	05/14/2002
6387938	Benzimidazole derivatives This invention provides novel benzimidazole derivatives represented by the formula (I); a process for producing the same; a drug containing at least one of such compounds as its active ingredient, in particular, a drug for preventing and/or treating disea...	05/14/2002
6376671	2-sulfamoylbenzoic acid derivatives 2-Sulfamoylbenzoic acid derivatives of general formula (I): ##STR1## which have both an antagonistic effect on the leukotriene D4 receptor and an antagonistic effect on the thromboxane A2 receptor and salts thereof, pharmaceuticals, ...	04/23/2002
6365584	Arylysulphonamide-substituted benzimidazoles having tryptase-inhibiting activity Arylsulphonamide-substituted benzimidazole derivatives of formula (I) ##STR1## having tryptase-inhibiting activity. Exemplary are: 1-Methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(2-diethylaminoethyl)-benzenesu lphonylamino]-benzimidazole; 1-Methyl-2-[2-(4-amidinop...	04/02/2002
6348482	Catechols as antimicrobial agents Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: ##STR1## wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino...	02/19/2002
6326369	Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi...	12/04/2001
6316474	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists Benzimidazoles, substituted in the 2-position by substituted benzyl groups or heteroaryl groups are effective as NMDA NR2B antagonists and are useful for relieving pain....	11/13/2001
6291499	2-cyclohexyl benzimidazole NMDA/NR2B antagonists Novel 4-substituted cyclohexanes substituted in the 1-position with 2-benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C1 -C4 alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective a...	09/18/2001
6288100	Benzimidazole derivatives Disclosed herein are compounds of formula I or II: ##STR1## wherein R is alkyl phenyl or substituted phenyl; R2 is hydrogen, halogen, alkoxy or alkyl; R1 is hydrogen, alkyl, aryl, arylalkyl, or substituted benzyl; or a pharmaceutically accepta...	09/11/2001
6277849	N-sulphonyl and N-sulphinyl amino acid amides as microbiocides The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1 -C12 alkyl that is unsubs...	08/21/2001

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Class 548/310.1 - Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding