Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 8143422 | Benzimidazole derivatives The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and este... | 03/27/2012 |
| 8093402 | Benzimidazole derivatives Provided herein are compounds in accord with Formula I: that are useful in the treatment of pain. ... | 01/10/2012 |
| 8093401 | Sirtuin modulating compounds Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, dis... | 01/10/2012 |
| 8008503 | Methyl-benzimidazole derivatives The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable s... | 08/30/2011 |
| 7906654 | Benzimidazole derivatives Provided herein are compounds in accord with Formula I: that are useful in the treatment of pain. ... | 03/15/2011 |
| 7884215 | 2-substituted benzimidazoles Inhibitors of RSV replication of formula (I) the addition salts and stereochemically isomeric forms thereof, wherein Q is hydrogen, C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both —OR4 an... | 02/08/2011 |
| 7880016 | Process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides The invention relates to a process for preparing a salt of an optionally substituted 4-benzimidazol-2-ylmethylamino)-benzamidine, characterised in that (a) an optionally correspondingly substituted diaminobenzene is condensed with 2-[4-(1,2,4-oxadiazol-... | 02/01/2011 |
| 7825258 | Methyl-benzimidazole derivatives The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable s... | 11/02/2010 |
| 7816540 | Carboxyl- or hydroxyl-substituted benzimidazole derivatives This invention relates to novel carboxyl- or hydroxyl-substituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiological... | 10/19/2010 |
| 7790904 | Substituted benzimidazole derivatives The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 and X are as defined in the description and in the claims, as well as physiologically accept... | 09/07/2010 |
| 7608723 | Indole and benzimidazole derivatives The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compou... | 10/27/2009 |
| 7501526 | Synthesis of polyamine compounds This invention relates to methods of preparing the compounds of formula (V): Each variable in this formula is defined in the specification. ... | 03/10/2009 |
| 7482469 | 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives The invention relates to 2-(benzimidazol-1-yl)-acetamide bisaryl derivative having the general Formula I wherein n is 0 or 1; Ar1 represents a diradical derived from a 5- or-6-membered aromatic ring, optionally c... | 01/27/2009 |
| 7468440 | Malonamides and malonamide derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 12/23/2008 |
| 7358359 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 04/15/2008 |
| 7345068 | Aromatic amino acid derivatives and medicinal compositions 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group, ... | 03/18/2008 |
| 7332608 | Anthranilamides and methods of their use The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and p... | 02/19/2008 |
| 7329684 | Benzimidazole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 02/12/2008 |
| 7326791 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions Substituted carboxylic acid amides of general formula wherein A, B, and R1 to R5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable s... | 02/05/2008 |
| 7326812 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 02/05/2008 |
| 7304082 | 1,2,4-triazole derivatives, compositions, process of making and methods of use Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovasculari... | 12/04/2007 |
| 7279495 | Benzimidazol- or indol-aminoacetonitrile derivatives for parasite control The invention relates to compounds of the general formula wherein R1, R2, R3, R4, R5, R6, R7, X, Y and a have the significances given i... | 10/09/2007 |
| 7271261 | Substituted benzimidazoles and imidazo-[4,5]-pyridines 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 09/18/2007 |
| 7271271 | Imidazolo-related compounds, compositions and methods for their use Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are usef... | 09/18/2007 |
| 7265142 | Materials and methods for the treatment of hypertension and angina The subject invention provides useful and novel calcium channel blockers based upon mibefradil. The subject invention also provides methods for synthesizing the compounds of the invention. The invention also provides methods for the control or prevention of hyperten... | 09/04/2007 |
| 7244847 | Benzimidazole compounds The present invention is directed to novel benzimidazoles according to representative structures I and II, and their derivatives that possess antibacterial activity. This invention is also directed to compositions including the benzimidazole derivatives, and methods... | 07/17/2007 |
| 7235690 | Anthranilamides and methods of their use The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations con... | 06/26/2007 |
| 7202261 | Calcilytic compounds The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect i... | 04/10/2007 |
| 7202368 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines A process for preparing an optionally substituted 4-benzimidazol-2-ylmethylamino)benzamidine, the process comprising: (a) condensing an optionally suitably substituted diaminobenzene with 2-[4-(1,2,4-oxadiazol-5-on-3-yl)phenylamino... | 04/10/2007 |
| 7173053 | N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R1 represents hydrogen, methyl or triflur... | 02/06/2007 |
| 7169801 | Histone deacetylase inhibitors Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0–10 atoms... | 01/30/2007 |
| 7161033 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 01/09/2007 |
| 7160915 | N-methyl-substituted benzamidazoles The present invention relates to N-methyl-substituted benzamidazole derivatives of formula (I): as defined in the specification; pharmaceutical compositions and methods of use thereof. ... | 01/09/2007 |
| 7148234 | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases Methods of treating IL-6 involved diseases with EP4 receptor ligands, including EP4 receptor antagonists. Assays to determine the effect of test compounds on PGE2-induced whole blood cells activation. ... | 12/12/2006 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 7118811 | Materials for light emitting devices consisting of novel compounds and light emitting devices using the same A compound represented by formula (IA) or (IIA): wherein R11, R12 and R13 each represents a hydrogen atom, an aliphatic hydrocarbon group, an aryl group or a heterocyclic group; L... | 10/10/2006 |
| 7115646 | Cyclic diamines and derivatives as factor Xa inhibitors The present application describes cyclic diamino compounds, derivatives thereof, and pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa. ... | 10/03/2006 |
| 7087632 | Benzimidazole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 08/08/2006 |
| 7071358 | Arylsulfonamidobenzylic compounds Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases. ... | 07/04/2006 |
| 7056932 | Heterocyclyl substituted 1-alkoxy acetic acid amides The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as ... | 06/06/2006 |
