Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7419995 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazol... | 09/02/2008 |
| 7348438 | Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 03/25/2008 |
| 7250427 | Aryl-substituted benzimidazole and imidazopyridine ethers Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. ... | 07/31/2007 |
| 7232817 | α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/19/2007 |
| 7160915 | N-methyl-substituted benzamidazoles The present invention relates to N-methyl-substituted benzamidazole derivatives of formula (I): as defined in the specification; pharmaceutical compositions and methods of use thereof. ... | 01/09/2007 |
| 7132547 | Preventives/remedies for urinary disturbance Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving... | 11/07/2006 |
| 7019003 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 03/28/2006 |
| 6936613 | Benzimidazole derivatives and pharmaceutical compositions comprising these compounds The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders,... | 08/30/2005 |
| 6891043 | Inhibitors of fatty acid amide hydrolase Potent inhibitors of fatty acid amide hydrolase (FAAH) are constructed having K1's below 200 pM and activities 102-103 times more potent than the corresponding trifluoromethyl ketones. The potent inhibitors combine several features, ... | 05/10/2005 |
| 6770666 | Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therapeutic agent for hepatitis C... | 08/03/2004 |
| 6710056 | Amidinophenylpyruvic acid derivatives An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII. ... | 03/23/2004 |
| 6469039 | Disubstituted bicyclic heterocycles, the preparation and the use thereof as pharmaceutical compositions New disubstituted bicyclic heterocycles of general formula Ra --A--Het--B--Ar--E (I) Compounds of the above general formula I, wherein E denotes an Rb NH--C(.dbd.NH)-- group, have valuable pharmacological properties, particularly a throm... | 10/22/2002 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6414008 | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions New disubstituted bicyclic heterocycles of general formula Ra --A--Het--B--Ar--E (I) Compounds of general formula I, wherein E is an Rb NH--C(.dbd.NH)-- group, have valuable pharmacological properties, particularly a thrombin-inhibiting ... | 07/02/2002 |
| 6352985 | Benzimidazole compounds A benzimidazole compound represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable... | 03/05/2002 |
| 6323227 | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by t... | 11/27/2001 |
| 6291499 | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists Novel 4-substituted cyclohexanes substituted in the 1-position with 2-benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C1 -C4 alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective a... | 09/18/2001 |
| 6204264 | Benzimidazole derivative, hair growth promoter and external composition for skin using the same A benzimidazole derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is --(CH2)n --NR2 R | 03/20/2001 |
| 6194396 | Benzimidazole compounds as bradykinin antagonists This invention relates to a heterocyclic compound of the formula ##STR1## wherein a group of the formula: ##STR2## is a group of the formula ##STR3## X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl,... | 02/27/2001 |
| 6166219 | Benzimidazole derivatives Novel benzimidazole derivatives represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceuticall... | 12/26/2000 |
| 6083961 | Benzimidazole compounds as bradykinin antagonists This invention relates to a heterocyclic compound of the formula: ##STR1## wherein a group of the formula: ##STR2## is a group of the formula: ##STR3## etc., X is O, S or N--R5, R1 is lower alkyl, etc., R5 i... | 07/04/2000 |
| 6080767 | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula I herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used ... | 06/27/2000 |
| 6043257 | Amidinoindoles, amidinoazoles, and analogs thereof The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W1, W2, and W3 are selected from CH and N, provided that one of W1 and W2 is... | 03/28/2000 |
| 6022872 | - and ଲ-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/08/2000 |
| 5994557 | Method of acylating amines using N,N'-diacylimidazolone derivatives The present invention provides a method of acylating organic amines using N,N'-diacylimidazolone derivatives represented by the general formula I as follows: ##STR1## wherein R1 and R2 are the same or different, which are select... | 11/30/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5849759 | Naphthyl-substituted benzimidazole derivatives as anti-coagulants Compounds of formula (I): ##STR1## wherein: n, A, R1, R2, R3, and R4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants.... | 12/15/1998 |
| 5840917 | Phosphorylamides, their preparation and use A phosphorylamide derivative represented by the general formula (I): ##STR1## wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobac... | 11/24/1998 |
| 5827860 | Peptidyl heterocycles useful in the treatment of thrombin related disorders Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.... | 10/27/1998 |
| 5827866 | Peptidyl heterocycles useful in the treatment of thrombin related disorders Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.... | 10/27/1998 |
| 5817823 | Method for synthesizing 2-substituted imidazoles The present invention is a method of preparing 2-substituted imidazoles from readily available imidazoles having a leaving group in the 2-position, by alkylating the imidazole under mild conditions to afford a 3-N-alkylated imidazolium salt; and coupling ... | 10/06/1998 |
| 5719141 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amide derivatives Compounds of the formula I ##STR1## in which R1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R2 and R... | 02/17/1998 |
| 5635525 | Benzimidazole derivatives as angiotensin II receptor antagonists, pharmacticals, and treatment of hypertension therewith A compound of the formula ##STR1## in which the symbols have the following meaning: X is a monocyclic radical having 3, 4 or 5 ring atoms, R1, R2, R3, R4, R12 and R13 are, for example, ... | 06/03/1997 |
| 5554633 | Substituted amines as tachykinin receptor antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H or C1-6 alkyl; R1 | 09/10/1996 |
| 5502187 | Pharmaceutically active bicyclic-heterocyclic amines The pharmaceutically active bicyclic heterocyclic amines (XXX) ##STR1## where W1 is --N.dbd. or --CH.dbd.; W3 is --N.dbd. or --CH.dbd.; W5 is --N.dbd. or --CR5 -- with the proviso that W5 is --CR... | 03/26/1996 |
| 5496942 | 5-substituted tetrahydrobenzimidazole compounds A process is provided for preparing a tetrahydrobenzimidazole derivative represented by Formula (Ib): ##STR1## wherein Het representa s heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower... | 03/05/1996 |
| 5391819 | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists Disclosed herein is a process of making chiral 2-aryl-1,4-butanediamine derivatives useful as neurokinin-A antagonists of Formula 7 ##STR1##... | 02/21/1995 |
| 5389634 | Imidazole derivatives having angiotensin II receptor antagonistic activity Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.... | 02/14/1995 |
| 5338847 | Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation Described are a class of chemiluminescent compound characterized by the presence an aryl ester, thioester or amide of a carboxylic acid substituted heterocyclic ring that is susceptible to chemical attack (such as by oxidic attack) to dissociate the heter... | 08/16/1994 |
| 5338756 | Benzimidazole compounds Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.... | 08/16/1994 |
