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| Number | Title | Issue Date |
| 7875727 | Benzimidazole vascular damaging agents Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid t... | 01/25/2011 |
| 7795445 | Substituted 2-aminoalkylthiobenzimidazole compounds, pharmaceutical compositions thereof and methods for their use The present invention comprises the substituted 2-aminoalkylthiobenzimidazoles of formula I wherein R1-R5 and R11-R16 are hereinafter defined. These compounds, their derivatives and the pharmaceutically acceptable salts the... | 09/14/2010 |
| 7495110 | Benzimidazole derivatives and their use as GnRH antagonists A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R1, R2, R3 and R4 represent different variable groups. These products have an antag... | 02/24/2009 |
| 7399772 | Substituted benzimidazole dosage forms and method of using same The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting of a proton pump inhibitor and at least one buffering agent. Also prov... | 07/15/2008 |
| 7332505 | Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is optionally substituted with at least one NO and/or NO2 group, and, ... | 02/19/2008 |
| 7268145 | Thiobenzimidazole derivatives The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt th... | 09/11/2007 |
| 7078420 | Spiro-hydantoin compounds useful as anti-inflammatory agents Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, whe... | 07/18/2006 |
| 7030139 | Compounds Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain | 04/18/2006 |
| 7015332 | 2-thioalkyl-benzimidazole-5 or 6 sulphonic acids A compound represented by formula (I): a compound represented by (II): or a mixture of at least one compound represented by formula (I) with at least one compound represent... | 03/21/2006 |
| 6982275 | Process for producing optically active sulfoxide derivative The present invention relates to a production method of an optically active form of a compound represented by formula (II) wherein ring A is a benzene ring optionally having substituent(s); R1 is H, a hydroca... | 01/03/2006 |
| 6977267 | Spiro-hydantoin compounds useful as anti-inflammatory agents Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L... | 12/20/2005 |
| 6936613 | Benzimidazole derivatives and pharmaceutical compositions comprising these compounds The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders,... | 08/30/2005 |
| 6903126 | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the pr... | 06/07/2005 |
| 6884894 | Method for producing bisphenol catalysts and bisphenols This disclosure relates to a method for producing and using catalysts in the production of bisphenols, and in particular to a method for producing catalysts which contain poly-sulfur mercaptan promoters, and using these catalysts in the production of bisphenol-A and... | 04/26/2005 |
| 6780576 | Surfactants A compound represented by formula (I): a compound represented by (II): or a mixture of at least one compound represented by formula (I) with at least one compound represented... | 08/24/2004 |
| 6645988 | Substituted benzimidazole dosage forms and method of using same The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical dosage form that is not enteric coated or delayed released containing a proton pum... | 11/11/2003 |
| 6642264 | Thiazolobenzoimidazole derivatives This invention relates to novel thiazolo[3,2-a]benzoimidazole derivatives represented by the following general formula (I). The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments. The inven... | 11/04/2003 |
| 6489346 | Substituted benzimidazole dosage forms and method of using same There is provided a solid pharmaceutical composition in a dosage form that is not enteric-coated, having active ingredients including a non-enteric coated proton pump inhibitor and at least one buffering agent. The proton pump inhibitor is omeprazole, lan... | 12/03/2002 |
| 6472414 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters... | 10/29/2002 |
| 6376666 | 2-mercaptobenzimidazole derivatives possessing pharmacological activity 2-mercaptobenzimidazole derivatives of the general formula ##STR1## wherein: N=0,2,3; R-hydrogen atom, aralkyls; R1-lower alkyls, alkenyls, dialkylamino, a saturated amine monocyclic residue which may contain an additional heteroatom; R2 and R | 04/23/2002 |
| 6362208 | Anilide compounds and drugs containing the same The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: ##STR1## represents a divalent residue of benzene with a substituent(... | 03/26/2002 |
| 6242611 | Phenylimidazolidines containing nitrooxy or carbonyloxy groups A subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, substituted in particular by nitr... | 06/05/2001 |
| 6194396 | Benzimidazole compounds as bradykinin antagonists This invention relates to a heterocyclic compound of the formula ##STR1## wherein a group of the formula: ##STR2## is a group of the formula ##STR3## X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl,... | 02/27/2001 |
| 6191157 | Hetero-linked phenylglycinolamides The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.... | 02/20/2001 |
| 6172057 | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/09/2001 |
| 6166219 | Benzimidazole derivatives Novel benzimidazole derivatives represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceuticall... | 12/26/2000 |
| 6087509 | 1-Imidazolidinyl-phenyls A particular subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, optionally s... | 07/11/2000 |
| 6083961 | Benzimidazole compounds as bradykinin antagonists This invention relates to a heterocyclic compound of the formula: ##STR1## wherein a group of the formula: ##STR2## is a group of the formula: ##STR3## etc., X is O, S or N--R5, R1 is lower alkyl, etc., R5 i... | 07/04/2000 |
| 6069247 | Process for preparing substituted acrylamides by reaction of propiolamides and aromatic rings The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 05/30/2000 |
| 6025378 | Bicyclic heterocyclic compounds The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compoun... | 02/15/2000 |
| 6022978 | Benzimidazole derivatives Benzimidazole Derivatives having the formulae ##STR1## wherein B, Y, R1, R2, R3 and R4 are as defined in the specification. These compounds and their pharmaceutically acceptable salts are useful in the trea... | 02/08/2000 |
| 6011045 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds... | 01/04/2000 |
| 5994557 | Method of acylating amines using N,N'-diacylimidazolone derivatives The present invention provides a method of acylating organic amines using N,N'-diacylimidazolone derivatives represented by the general formula I as follows: ##STR1## wherein R1 and R2 are the same or different, which are select... | 11/30/1999 |
| 5990145 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I, A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compound... | 11/23/1999 |
| 5972958 | 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones This invention relates to a novel series of compounds having potency at the dopamine D2 receptor which are illustrated by the following Formula I: ##STR1## wherein: R1 is hydrogen or C1 -C6 alkyl; R2 | 10/26/1999 |
| 5948789 | Process for synthesis of substituted sulphoxides A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their ... | 09/07/1999 |
| 5929244 | Process for the optical purification of enantiomerically enriched benzimidazole derivatives Process for the optical purification of the single enantiomers of some 2-sulphinyl-1H-benzimidazole derivatives and another structurally related sulphoxide from the respective enantiomerically enriched preparation thereof.... | 07/27/1999 |
| 5919792 | Integrin antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are v댣 antagonists, ... | 07/06/1999 |
| 5917038 | Process of preparing substituted acrylamides The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 06/29/1999 |
| 5912356 | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring Antiviral purine nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Methods of treating herpes viral infections and pharmaceutical formulations are also described.... | 06/15/1999 |
