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| Number | Title | Issue Date |
| 7438893 | Polybiotin compounds for magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ... | 10/21/2008 |
| 7332613 | Capture and release based isotope tagged peptides and methods for using the same The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association w... | 02/19/2008 |
| 7314932 | Methods for minimizing thioamide impurities Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrite groups, are provided. ... | 01/01/2008 |
| 7270954 | Hybridization of target DNA with immobilized nucleic acid analogs This invention is related to the immobilization of peptide nucleic acids (PNAs) onto solid surfaces for use in hybridization, purification, biosensing, and other biochemical applications. Specifically, their use to increase the thermal stability, specificity, and li... | 09/18/2007 |
| 7262221 | Amphiphilic star-like macromolecules for drug delivery The present invention provides polymeric compounds that can form micelles in solutions. These compounds have a hydrophobic, core that is coupled to a plurality of hydrophilic moieties. ... | 08/28/2007 |
| 7238842 | Covalent tethering of functional groups to proteins A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 07/03/2007 |
| 7235376 | Gastrin hormone immunoassays The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bod... | 06/26/2007 |
| 7198893 | DNA diagnostics based on mass spectrometry Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromo... | 04/03/2007 |
| 7145019 | Photocleavable isotope-coded affinity tags This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in vivo and in vitro sources. Agents comprise a detectable group bound ... | 12/05/2006 |
| 7112600 | Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a therape... | 09/26/2006 |
| 7109198 | Method for treating obesity The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in comb... | 09/19/2006 |
| 7102005 | Compositions and methods for detection and isolation of phosphorylated molecules The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules... | 09/05/2006 |
| 7078013 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are... | 07/18/2006 |
| 6956695 | System and method for increasing the contrast of an image produced by an epifluorescence microscope The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objecti... | 10/18/2005 |
| 6756384 | Imidazole compounds A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatm... | 06/29/2004 |
| 6753410 | Investigational compounds The present invention is directed to compounds and pharmaceutical compositions comprising the compounds which are inhibitors of the enzyme gamma secretase and which are useful in the treatment or prevention of diseases in which the beta-amyloid peptide is involved, ... | 06/22/2004 |
| 6703368 | Peptide-containing -ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing -ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.... | 03/09/2004 |
| 6503925 | 1-phenyl-benzimidazole compounds and their use as GABA-A receptor modulators Chemical compounds of the formula ##STR1## as well as pharmaceutical compositions containing them and methods for their use in the treatment of disorders and diseases responsive to modulation of the GABAA receptor complex of the central nervous... | 01/07/2003 |
| 6437147 | Imidazole compounds A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for... | 08/20/2002 |
| 6218546 | Reagent for the detection and isolation of carbohydrates or glycan receptors The invention concerns compounds which have a chromophore and a group capable of binding to streptavidin or/and avidin and which are suitable for binding to molecules containing an aldehyde, ketone, hemiacetal or/and hemiketal group. In addition the inven... | 04/17/2001 |
| 6187913 | Covalently crosslinked oligonucleotides, preparation method and synthon which is of use in the method A double- or single-stranded oligonucleotide comprising one or more respectively inter- or intra-oligonucleotide covalent cross-linkages, wherein the or each covalent linkage consists of an amide bond between a primary amine group of one strand and a carb... | 02/13/2001 |
| 6022966 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin, as well as related compounds, are described. Articles of manufactur... | 02/08/2000 |
| 5955605 | Biotinidase resistant biotin-DOTA conjugates Biotinidase-resistant biotin-DOTA conjugates, and methods of use thereof in diagnostic and therapeutic pretargeting methods are provided. These conjugates are useful in diagnosis and treatment of cancer.... | 09/21/1999 |
| 5952185 | Photo-activatable biotin derivatives and their use to reduce interference in immunoassays The invention addresses new photo-activatable biotin derivatives having the formula I ##STR1## wherein R=(CH2)n --Om !q --(CH2)r --Os !t --(CH2) | 09/14/1999 |
| 5886175 | 7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.... | 03/23/1999 |
| 5869698 | 1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an `activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from... | 02/09/1999 |
| 5856571 | Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are semicarbazide-containing linker compounds useful in forming conjugates having stable semicarbazone linkages. The stably-linked conjugates have utility in a... | 01/05/1999 |
| 5851840 | Biotinsilane compounds and a binding matrix containing these compounds The invention concerns a binding matrix containing a carrier material with an oxidic surface and a solid phase reactant covalently bound thereto via anchor groups which is capable of binding to at least one free reaction partner, which is characterized in... | 12/22/1998 |
| 5843937 | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomer... | 12/01/1998 |
| 5814650 | Biotin amides able to control glucidic metabolisms under dysmetabolic conditions and relative therapeutical compositions Described herein are biotin amides which are able to control glucidic metabolism under dysmetabolic conditions and relative therapeutical compositions for the treatment of insulin-independent diabetes, insulin-dependent diabetes and relative complicating ... | 09/29/1998 |
| 5807879 | Biotinidase-resistant biotinylated compound and methods of use thereof The present invention provides biotinylated compounds useful for delivering a molecule to a target site, and methods of making biotinylated compounds. The biotinylated compounds are covalent conjugates of biotin and a diagnostic or therapeutic agent, and ... | 09/15/1998 |
| 5789588 | Carbodiimide derivative The present invention relates to a carbodiimide derivative represented by the following general formula: W1 --X--N.dbd.C.dbd.N--Y--W2 --Z wherein W1 is a straight chain, branched chain or cyclic saturated or unsaturated aliphat... | 08/04/1998 |
| 5783171 | Radionuclide metal N2 S2 chelates substituted with glucose and biotin moieties Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, or catabolites the... | 07/21/1998 |
| 5716594 | Biotin compounds for targetting tumors and sites of infection Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.... | 02/10/1998 |
| 5700935 | Carbodiimide derivative The present invention relates to a carbodiimide derivative represented by the following general formula: W1 --X--N.dbd.C.dbd.N--Y--W2 --Z wherein W1 is a straight chain, branched chain or cyclic saturated or unsaturated aliphat... | 12/23/1997 |
| 5630996 | Two-step pretargeting methods using improved biotin-active agent conjugates Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related com... | 05/20/1997 |
| 5608060 | Biotinidase-resistant biotin-DOTA conjugates Biotinidase-resistant biotin-DOTA conjugates, and methods of use thereof in diagnostic and therapeutic pretargeting methods are provided. These conjugates are useful in diagnosis and treatment of cancer.... | 03/04/1997 |
| 5532379 | Biotin containing heterobifunctional cleavable compounds Trifunctional cross-linking compounds are disclosed. The compounds contain the biotin moiety, the NHS active ester, and a photoactivatable aryl azide. The presence of a disulfide bond in association with either the ester or azide permits the compound to b... | 07/02/1996 |
| 5527711 | Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques A method is provided for detecting an analyte of interest in a sample. The method involves binding the analyte to the surface of a substrate through a biotin-biotin binding protein interaction, contacting the surface-bound analyte with a quantitatively de... | 06/18/1996 |
| 5514694 | Peptidyl ketoamides A novel class of peptide -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y--CO... | 05/07/1996 |
