Class 548/303.1 - At least three ring hetero atoms in the bicyclo ring system (e.g., furo- imidazole, (1,2-a) imidazole, pyrazo (1,2-a) imidazolidine, etc.)

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the bicyclo ring system contains at least
No. of patents: 119
Last issue date: 09/28/2010

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Number	Title	Issue Date
7803952	Manufacture of lactones The present invention relates to a process for the manufacture of cyclic monocarboxylic esters (lactones) and related compounds by hydrogenation of cyclic dicarboxylic acid anhydrides in the presence of metal catalysts. ...	09/28/2010
7470795	Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules...	12/30/2008
7385056	Synthesis of heteroaryl acetamides An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst. In one embo...	06/10/2008
7351481	Imidazole ring-containing compound and organic electroluminescence display device The present invention is related to an imidazole ring-containing compound and an organic electroluminescence (EL) display device using the same. In particular, the imidazole ring-containing compound may be used alone or in combination with a dopant as a material for...	04/01/2008
7253154	Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m...	08/07/2007
7241788	Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ...	07/10/2007
7238699	Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu...	07/03/2007
7229988	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen spe...	06/12/2007
7211669	Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu...	05/01/2007
7205406	Azomethine dye and metal complex dye, as well as color toner and ink-jet ink using the same An azomethine dye represented by the following Formula 1: wherein Y represents a substituent of 0.2≦σp≦0.9, Z1 and Z2 each represent —CR1═, where R1 represents...	04/17/2007
7186740	Imidazopyrazines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of imidazo[1,2-a] pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of p...	03/06/2007
7161371	Module part A module component which includes circuit substrate 3 having one or more components 1 on at least one of the surfaces, and junction circuit substrate 5 having hollow 4, or hole, disposed corresponding to the portion of the one or more com...	01/09/2007
7153873	Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceut...	12/26/2006
7126006	Glycoluril core molecules for combinatorial libraries The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinato...	10/24/2006
7105564	Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I):	09/12/2006
6962942	Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F...	11/08/2005
6939973	Glycoluril core molecules for combinatorial libraries The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinato...	09/06/2005
6936631	Bicyclic imidazo-5-yl-amine derivatives A novel bicyclic imidazo-5-yl-amine derivative of Formula I, wherein X denotes CR5, N or S, and Y in the case where X denotes S, denotes CR6 or N and in all other cases denotes N, and methods for ...	08/30/2005
6897208	Benzimidazoles The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compo...	05/24/2005
6888004	Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for ...	05/03/2005
6884893	Method for selectively dissociating cyclic carboxylic acid anhydrides The invention relates to a method for selectively dissociating cyclic carboxylic acid anhydrides. According to the inventive method, a chiral amino alcohol with a tertiary amino group that may have a partially or completely bridged structure is used as the chiral au...	04/26/2005
6867208	Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the inven...	03/15/2005
6838074	Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrentl...	01/04/2005
6838462	Insecticidal azoles The present invention relates to novel heterocyclic compounds of formula (I) where A, R1, R2, Y, Z, and n are defined in the disclosure, to processes for their preparation, and to their use as crop protection agents, i...	01/04/2005
6815440	Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is invol...	11/09/2004
6812349	Process and intermediates for the preparation of imidazopyridines The invention relates to compounds of formula (2) in which R1, R2, R3 and R4 have the meanings indicated in the description, their preparation and their further reaction to give compounds of formula (1), in which A1, A2 and R4 have the meanings...	11/02/2004
6716990	Process and intermediates for the preparation of imidazopyridines The invention relates to compounds of formula (2) in which R1, R2, R3 and R4 have the meanings indicated in the description, their preparation and their further reaction to give compounds of formula (1), in which A1, A2 and R4 have the meanings...	04/06/2004
6703368	Peptide-containing ଱-ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing ଱-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same....	03/09/2004
6689804	Small molecules useful in the treatment of inflammatory disease A method for treating inflammatory and immune cell-mediated diseases by the administration of compounds of the formula I ##STR1## Exemplary are: ##STR2##...	02/10/2004
6664282	Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual com...	12/16/2003
6664283	Pharmaceuticals for neurogenic pain This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention....	12/16/2003
6620529	Materials for light emitting devices and light emitting devices using the same A compound represented by general formula (113): ##STR1## wherein R1 and R2 each represents a hydrogen atom, an aliphatic hydrocarbon group, an aryl group or a heterocylic group; Z1 represents an atomic group necessary to ...	09/16/2003
6545032	Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual com...	04/08/2003
6492408	Small molecules useful in the treatment of inflammatory disease Compounds of the formula I ##STR1## which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are: ##STR2##...	12/10/2002
6479527	Bicyclic pyrrole derivatives as MCP-1 inhibitors A pharmaceutical composition comprising a compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1 and wherein A and B together form an optionally substitu...	11/12/2002
6461747	Heterocyclic compounds, materials for light emitting devices and light emitting devices using the same Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L.paren open-st.A)m...	10/08/2002
6462041	Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by the general Formulae I-III: ##STR1## wherein R1 -R5 are defined herein. The present invention also relates to the discovery that comp...	10/08/2002
6433183	(R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dihydroimidazo[1, 2-a]imidazole-2,5-dione A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1 ,2-଱]imidazol-2-one (1): ##STR1## This compound is useful as an intermediate in the preparation of certain small molecules that are...	08/13/2002
6414161	Synthesis of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1 ,2-a]imidazol-2-one A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl- 1-H-imidazo[ 1 ,2-a]imidazol-2-one (1): ##STR1## This compound is useful as an intermediate in the preparation of certain small molecules that are us...	07/02/2002
6359144	Combinatorial libraries of bicyclic guanidine derivatives and compounds therein The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well...	03/19/2002

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Class 548/303.1 - At least three ring hetero atoms in the bicyclo ring system (e.g., furo- imidazole, (1,2-a) imidazole, pyrazo (1,2-a) imidazolidine, etc.)