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| Number | Title | Issue Date |
| 8143420 | Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of ... | 03/27/2012 |
| 7741493 | Heterocyclic compounds as P2X7 ion channel blockers The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are ... | 06/22/2010 |
| 7541476 | Radiolabeled astemizole and method of making The present invention provides a radiolabeled astemizole of formula (III) and a process for preparing the radiolabeled astemizole of formula III. ... | 06/02/2009 |
| 7442717 | Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed ... | 10/28/2008 |
| 7439369 | Method and system for hydrogen evolution and storage A method and system for storing and evolving hydrogen employ chemical compounds that can be hydrogenated to store hydrogen and dehydrogenated to evolve hydrogen. A catalyst lowers the energy required for storing and evolving hydrogen. The method and system can provi... | 10/21/2008 |
| 7419995 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazol... | 09/02/2008 |
| 7405234 | Bicyclic modulators of androgen receptor function The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds... | 07/29/2008 |
| 7396840 | Chemokine receptor binding heterocyclic compounds Tertiary amine compounds that bind chemokine receptors such as CXCR4 and CCR5 are disclosed. ... | 07/08/2008 |
| 7385056 | Synthesis of heteroaryl acetamides An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst. In one embo... | 06/10/2008 |
| 7375235 | Process for preparing substituted benzimidazole compounds The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity. ... | 05/20/2008 |
| 7371870 | Benzimidazolone compound There are provided benzimidazolone compounds that provide a plurality of hues from a single structural formula, and are useful as pigments that offer superior dispersibility in binder resins, as well as benzimidazolone compounds that are useful as pigments, and show... | 05/13/2008 |
| 7368467 | Ion channel modulators The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and... | 05/06/2008 |
| 7365209 | Nitrogen heterocycle biaryls for osteoporosis and other diseases Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity. Compounds of formula: | 04/29/2008 |
| 7351732 | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for which an agonist of these receptors is indicated. They a... | 04/01/2008 |
| 7345074 | Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. ... | 03/18/2008 |
| 7314940 | Jun kinase inhibitors The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particula... | 01/01/2008 |
| 7304067 | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. ... | 12/04/2007 |
| 7279495 | Benzimidazol- or indol-aminoacetonitrile derivatives for parasite control The invention relates to compounds of the general formula wherein R1, R2, R3, R4, R5, R6, R7, X, Y and a have the significances given i... | 10/09/2007 |
| 7250063 | Diaminopyrazole derivatives and their use for oxidation dyeing of keratinous fibres The invention concerns novel diaminopyrazole derivatives of formula (I), wherein: R1 represents C1-C6 alkyl or C2-C6, preferably up to C4, alkenyl, linear or branched, bearing at least a substituent s... | 07/31/2007 |
| 7214802 | Anti-cytokine heterocyclic compounds Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chr... | 05/08/2007 |
| 7193089 | Process for manufacture of telmisartan A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2′-yl)benzimidazole with a compound of formula (IV) wherein Z is a leaving group, to obtain the compound 2-cyano-4... | 03/20/2007 |
| 7192729 | Methods for assaying homocysteine The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay methods that employ, mutant SAH hydrolase having binding affinity for Hcy, ... | 03/20/2007 |
| 7186740 | Imidazopyrazines as cyclin dependent kinase inhibitors In its many embodiments, the present invention provides a novel class of imidazo[1,2-a] pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of p... | 03/06/2007 |
| 7179829 | Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic, and medicament comprising them The invention relates to novel compounds of the type of the imidazolidines of the formula I in which R1 to R7 are as defined in the claims. They are used for preparing a medicament for the treatment or pr... | 02/20/2007 |
| 7173053 | N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula —N(OH)CH(═O) or formula C(═O)NH(OH); R1 represents hydrogen, methyl or triflur... | 02/06/2007 |
| 7148215 | Chemical compounds The present invention concerns compounds of general formula (I): in which the substituents are as described herein. ... | 12/12/2006 |
| 7144893 | 4-aryl quinols and analogs thereof as therapeutic agents The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(... | 12/05/2006 |
| 7144909 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subcllinical hyperthyrodis... | 12/05/2006 |
| 7144700 | Photolithographic solid-phase polymer synthesis Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred gro... | 12/05/2006 |
| 7141598 | Imidazole derivatives, production method thereof and use thereof The present invention provides a compound having a steroid C17,20-lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active com... | 11/28/2006 |
| 7135493 | HDAC inhibitor A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), ... | 11/14/2006 |
| 7126006 | Glycoluril core molecules for combinatorial libraries The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinato... | 10/24/2006 |
| 7112680 | Heterocyclic hydrazones for use as anti-cancer agents The invention relates to novel 2-benzimidazolyl-, 2-benzoxazolyl- and 2-benzothiazolyl hydrazones that are derived from 2-formylpyridine, 2-acylpyridines, acetyldiazines and acetyl(iso)quinolines. The invention also relates to a novel method for producing 2-benzimid... | 09/26/2006 |
| RE39263 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides. ... | 09/05/2006 |
| 7094905 | Process for the hydrogenation of C—C double bonds The present invention relates to a gentle process for catalytic hydrogenation and to a process for the preparation of biotin using the hydrogenation step. The process according to the invention for the selective, catalytic hydrogenation of a C—C double bond on a t... | 08/22/2006 |
| 7067311 | 3′-phosphoadenosine-5′-phosphosulfate synthetase 1 (PAPSS1) sequence variants Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are describ... | 06/27/2006 |
| 7056354 | Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratinous fibers The invention concerns compounds derived from diaminopyrazole of formula (I), wherein: Ar is a 5- or 6-membered heteroaromatic radical capable of being condensed with one or several heteroaromatic cycles each comprising 5 or 6 members, and their physiologically acce... | 06/06/2006 |
| 7049333 | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis Substituted thiophenes, processes for their preparation, their use as medicament or diagnostic agent. The substituted thiophene derivatives have the following backbone structure: Medicaments comprising compounds of thi... | 05/23/2006 |
| 7034048 | Gastrin and cholecystokinin receptor ligands (III) Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R5)—(R5 being selected from H, Me, Et, Pr, Bn, OH and —CH2COOR | 04/25/2006 |
| 7026163 | Sulfotransferase sequence variants Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or c... | 04/11/2006 |
