Class 548/300.7 - Spiro

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain a spiro ring system.
No. of patents: 110
Last issue date: 03/31/2009

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Number	Title	Issue Date
7511153	4-alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for thei...	03/31/2009
7365208	Method for preparing irbesartan and intermediates thereof A method for preparing irbesartan and intermediates thereof. Irbesartan has the structure of formula I, ...	04/29/2008
7301035	Intermediates for the synthesis of irbesartan Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected ...	11/27/2007
7217825	Synthesis of irbesartan Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected ...	05/15/2007
7211676	Method for preparing irbesartan and intermediates thereof A method for preparing irbesartan and intermediates thereof. Irbesartan has the structure of formula I, ...	05/01/2007
7153973	Imidazolidinone derivatives A compound of the formula (IA) or (IB) wherein G1, G2, G3 and G4 are independently of one another C1–C18alkyl...	12/26/2006
7074937	Method for production of additives for lubricating oils A method for making a compound of formula (I) wherein bonds a and b are single or double bonds, provided that one of a and b is a single bond and the other is a double bond; one of B1 and B2	07/11/2006
7019148	Synthesis of irbesartan Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected ...	03/28/2006
6977267	Spiro-hydantoin compounds useful as anti-inflammatory agents Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L...	12/20/2005
6960474	Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and u...	11/01/2005
6924330	Thioimidazolidine derivatives as light stabilizers for polymers A compound of the formula (I) wherein G1, G2, G3 and G4 are independently of one another C1-C18alkyl or C5-C12cycloalkyl or the radicals G1 and G2 and the r...	08/02/2005
6906053	Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R	06/14/2005
6897208	Benzimidazoles The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compo...	05/24/2005
6890915	Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R	05/10/2005
6803368	Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, To...	10/12/2004
6683709	Photochromic pyran compounds Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By int...	01/27/2004
6638937	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutica...	10/28/2003
6316437	Spirohydantoin compounds and uses thereof Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of ben...	11/13/2001
6162923	Process for the preparation of imidazolones The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their salts, wherein the compound of formula (II...	12/19/2000
6162922	Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst Disclosed is a process for preparing N-substituted heterocyclic derivatives and its salts using phase transfer catalysis....	12/19/2000
5910595	Process for preparing oximidazoles A process is disclosed for the preparation of an imidazolone and the pharmaceutically acceptable salts thereof having the formula ##STR1## wherein R1 and R2 are the same or different and are C1 to C6 alkyl, C2 to C6 alkenyl, C1 to C6 cycloalkyl, aryl...	06/08/1999
5869698	1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an `activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from...	02/09/1999
5840217	Spiro compounds and their use as electroluminescence materials Use of spiro compounds of the formula (I) ##STR1## where K1 and K2 are, independently of one another, conjugated systems, in electroluminescence devices. Preferred compounds of the formula (I) are 9,9'-spirobifluorene derivatives ...	11/24/1998
5830825	3-aryl-tetronic acid derivatives, the production thereof and the use thereof as antiparasitic agents The present invention relates to new 3-aryl-4-hydroxy-Ɗ3 -dihydrofuranone derivatives of the formula (I) ##STR1## in which A and B together with the carbon atom to which they are bonded form an unsubstituted or substituted 5- to 7-membere...	11/03/1998
5760029	Spirocycle integrin inhibitors This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3-8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro-4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are useful as antagonists of the ଱v ଲ	06/02/1998
5714599	Process for the preparation of ste specific 1'-spiro-nucleosides The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R8 and R9 are as defined in claim 1, and to novel i...	02/03/1998
5705654	Imidazolidines substituted with a heterocycle Described herein are novel imidazoles of the formula ##STR1## wherein the substituents are as defined in the disclosure and their non-toxic, pharmaceutically acceptable addition salts with acids and bases having antiandrogenic activity....	01/06/1998
5698704	Process for the preparation of 4-oxoimidazolinium salts 4-Oxoimidazolinium salts of the general formula: ##STR1## wherein R1 and R2 independently of one another are C1-10 -alkyl, C2-10 -alkenyl, C3-7 -cycloalkyl or optionally substituted aryl, arylalk...	12/16/1997
5696137	Azaheterocyclymethyl-chromans Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R6 represents hydrogen, hydroxyl, halogen or phenyl; and n represents an in...	12/09/1997
5629331	Process for the preparation of a tetrazole derivative in two crystalline forms and novel the crystalline forms thereof The present invention relates to a process for the preparation of the 2-n.butyl-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro [4.4]-non-1-en-4-one by reaction of the corresponding nitrile with an alkaline azide and triethylamine hydrochloride...	05/13/1997
5559233	Methods for preparing n-substituted heterocyclic derivatives The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1##...	09/24/1996
5556983	Phenylimidazolidines Novel phenyimidazolidines having the following formula ##STR1## wherein the substituents are as recited in the specification and their non-toxic, pharmaceutically acceptable acid addition salts having anti-androgenic activity....	09/17/1996
5512681	Angiotensin II receptor blocking imidazolinone derivatives Novel imidazolinone derivatives of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##...	04/30/1996
5486532	Benzospiroalkenes Compounds of formula (I): ##STR1## in which: X represents --CH2 --, --(CH2)2 --, --CH.dbd.CH--, --O--CH2 --, --S--CH2 --, --SO--CH2 -- or --SO2 --CH2 --, Y repres...	01/23/1996
5444082	3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same 3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular disorders, such as heart failure and hypertension, are disc...	08/22/1995
5434167	Imidazolines N-substituted by a biphenylmethyl group, their medical use and the pharmaceutical compositions therefor The invention relates to compounds of the formula ##STR1## in which X and R1 -R5 are defined in the specification and their salts where appropriate, all of which are useful as angiotensin II antagonists....	07/18/1995
5380743	Fungicidal compositions containing (benzylidene)-azolymethylcycloalkane (Benzylidene)-azolylmethylcycloalkane or -alkene of formula ##STR1## in which: A and A1 are hydrocarbon chains of 1 to 3 carbon atoms, R1, R2, R3, R4 and R5 are hydrocarbon radicals, X is haloge...	01/10/1995
5354727	2-(1-substituted-2-imidazolin-2-yl)benzoic and nicotinic acids and a method for their preparation 2-(1-Substituted-2-imidazolin-2-yl)benzoic and nicotinic acids, and derivatives thereof, which are effective in the control of undesirable plant species are described, Also described are a method for the herbicidal use of the compounds and a method for th...	10/11/1994
5352788	N-substituted heterocyclic derivatives The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1## wherein the substituents are as described in the specification, and to intermediates. The compounds are useful for antagonizing angiotensin ...	10/04/1994
5338740	Angiotensin II receptor antagonists The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Het wherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds as regulators...	08/16/1994

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Class 548/300.7 - Spiro