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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8080670 | Process for the preparation of irbesartan The present invention relates to a process for the preparation of 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]-1,3-diazaspiro[4,4]non-1-en-4-one by reaction of the corresponding nitrile with sodium azide and piperazine or its acid salt. ... | 12/20/2011 |
| 7812174 | Methods of preparing imidazole-based compounds Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I: ... | 10/12/2010 |
| 7759495 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 07/20/2010 |
| 7750166 | Ionic liquids containing a sulfonate anion The present invention relates to novel ionic liquids comprising a docusate, docusate variant, or other sulfonate anion. The ionic liquids may be conveniently made via, for example, metathesis. The ionic liquids are often hydrophobic and useful in many hydrocarbon co... | 07/06/2010 |
| 7745636 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 06/29/2010 |
| 7605271 | Superhigh purity ionic liquid Provided is an ionic liquid, represented by the formula K+A−, having a very low content of impurities, especially a low content of halogen ions and/or a low content of alkali metal, wherein K+is a quaternary ammonium ion, for examp... | 10/20/2009 |
| 7589214 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various ... | 09/15/2009 |
| 7521564 | Heterocyclic salts of HBS & HCS The use of novel new heterocyclic borane and carborane salt ingredients for use as energetic, high density propellant fuels and fuel additives, or for gas generator and hydrogen storage applications. These subject and unique heterocyclic borane and carborane salts a... | 04/21/2009 |
| 7495108 | Imidazoline derivatives having CB-antagonistic activity The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates,... | 02/24/2009 |
| 7442713 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3, R4 and p are as defined in the description. The compounds acco... | 10/28/2008 |
| 7442716 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to t... | 10/28/2008 |
| 7439395 | Process for the preparation of guanidinium salts The present invention relates to a two-step process for the preparation of guanidinium salts of the formula (1), where the substituents R have a meaning indicated in Claim, and A− is a sulfonate, alkyl- or arylsulfate, hydrogensulfate, imide, methanide,... | 10/21/2008 |
| 7425318 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 09/16/2008 |
| 7423150 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatme... | 09/09/2008 |
| 7419994 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 09/02/2008 |
| 7417151 | Boron-based organic cations and related methods Generally disclosed are boron-based organic cations, a method for their manufacture, a method for their use in ionic liquids, and a method for their use as phase-transfer catalysts. More specifically, the boron-based organic cations have an charge of 1+, 2+, or 3+. | 08/26/2008 |
| 7410506 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof The present disclosure relates to a novel family of dicationic bis-hydrazone compounds that may be used as direct dyes, and to a dye composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing medium, a... | 08/12/2008 |
| 7407910 | Ligands for asymmetric reactions The invention relates to a process for the manufacture of bidentate ligands of the formula IA and IIA, characterized in that N,N-(optionally substituted) dialkylamino phosphines bound to an aromatic carbon are lithiated in ortho-position and the lithiated compounds ... | 08/05/2008 |
| 7407977 | Substituted N-acyl-2-aminothiazoles There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea. ... | 08/05/2008 |
| 7396840 | Chemokine receptor binding heterocyclic compounds Tertiary amine compounds that bind chemokine receptors such as CXCR4 and CCR5 are disclosed. ... | 07/08/2008 |
| 7393366 | Agents for coloring keratin fibers The present invention relates to agents for coloring keratin fibers which comprise at least one zwitterionic azo dye of the general formula (I) where R1 is an alkylsulfonate radical of the formula (II), ... | 07/01/2008 |
| 7390829 | Alpha-2 adrenergic agonists A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto... | 06/24/2008 |
| 7385063 | Method for preparing imidazole derivatives The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing a... | 06/10/2008 |
| 7378433 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-... | 05/27/2008 |
| 7368467 | Ion channel modulators The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and... | 05/06/2008 |
| 7361677 | Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the v... | 04/22/2008 |
| 7358269 | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one A compound of the formula or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed. ... | 04/15/2008 |
| 7358369 | Radiolabelled phenylethyl imidazole carboxylic acid ester derivatives Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrat... | 04/15/2008 |
| 7351267 | Symmetrical diazo compounds comprising 2-imidazolium groups and a non-cationic linke, compositions comprising them, method of coloring, and device The present disclosure relates to symmetrical cationic diazo compounds of formula (I) below, their resonance forms, and also their acid addition salts and their solvates: wherein W1 radicals, which are identical,... | 04/01/2008 |
| 7345077 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4- (substituted cycloalkylmethyl) imidazol-2-ones and 4- (substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 03/18/2008 |
| 7345072 | Phenyltetrazole compounds Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules. ... | 03/18/2008 |
| 7335779 | Modulation of pathogenicity The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H... | 02/26/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7323433 | R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole The invention relates to R-(−)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof and their use either for treating fungal infections in humans and ani... | 01/29/2008 |
| 7323485 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic re... | 01/29/2008 |
| 7316851 | Electroluminescent material, electroluminescent element and color conversion filter An electroluminescent element is disclosed, comprising an electroluminescent material and a fluorescent substance emitting light having an emission maximum at the wavelength different from that of light emitted from the electroluminescent material upon absorption of... | 01/08/2008 |
| 7317032 | Imidazolyl inhibitors of 15-lipoxygenase The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions. ... | 01/08/2008 |
| 7301028 | Mitotic kinesin inhibitors The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which com... | 11/27/2007 |
| 7297797 | Pyrrolines The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, A1, A2, R5, R6, R7, R | 11/20/2007 |
| 7282068 | Polycationic azo compounds for dyeing keratin fibers, dye composition containing the same, and methods for making such compounds The present disclosure relates to compounds used as direct dyes, and dyeing compositions comprising such compounds. The disclosed compounds have the formula A-L-B, wherein A and B are chosen from arylazoimidazolium coloring functional groups, and L is a linker compr... | 10/16/2007 |
