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| Number | Title | Issue Date |
| 7507832 | Triazole PPAR modulators The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the... | 03/24/2009 |
| 7351731 | Azole derivatives and methods for making the same The present invention is broadly directed to azole derivatives that exhibit antifungal activity and methods for making the same. In one aspect, the invention includes carboxylic acid and phosphate ester derivatives of fluconazole that exhibit antifungal activity. In... | 04/01/2008 |
| 7169929 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor The present invention relates to a novel diaryl 1,2,4-triazole derivative of the following formula (1) as a highly selective cyclooxygenase-2 inhibitor, wherein R1, R2, R3, R4, R5, W and A is as defined in this ... | 01/30/2007 |
| 7115643 | Intermediate halophenyl derivatives and their use in a process for preparing azole derivatives Novel halophenyl derivatives of the general formula (I), wherein R1 is halogen, a leaving group or 1H-1,2,4-triazol-1-yl and R2 is ethynyl or carboxy, X1 is halogen and X2 and X3 are each independently hydrogen ... | 10/03/2006 |
| 7074867 | Ion conducting polymers A compound having the general formula (I): −O3S—R1—V1—R2—V2 wherein R1 is a hydrocarbon radical comprising C1 to C10 | 07/11/2006 |
| 7019144 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-Triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided. ... | 03/28/2006 |
| 6969727 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic a... | 11/29/2005 |
| 6849636 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 02/01/2005 |
| 6803380 | 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them 5-aryl-1H-triazole compounds of the formula are potent and selective COX-2 inhibitors. The invention further relates to pharmaceutical compositions containing these compounds. ... | 10/12/2004 |
| 6720428 | Method for producing 2-(1,2,4-triazol-1-yl)-ethanols According to a novel process, microbicidally active 2-(1,2,4-triazol-1-yl)-ethanols of the formula in which A1, A2, R1, R2, R3 and R4 are as define... | 04/13/2004 |
| 6670363 | Azole compounds as therapeutic agents for fungal infections The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This inven... | 12/30/2003 |
| 6589914 | Dihalopropene compounds, insecticidal/acaridcidal agents containing same, and intermediates for their production The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.... | 07/08/2003 |
| 6566383 | Sulfonyltriazol derivatives and their use for combating micro-organisms Sulphonyltriazoles of the formula ##STR1## wherein Hal, R1, R2 are as defined in the specification are provided along with a process for preparing these compounds and a process using these compounds to control the growth of microorga... | 05/20/2003 |
| 6420375 | Fused ring compounds, process for producing the same and use thereof To provide a novel compound of the formula: ##STR1## [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y i... | 07/16/2002 |
| 6395367 | Pentacyclic anion salts or tetrazapentalene derivatives and their uses as ionic conducting materials The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention includes an anionic portion combined with at least one cationic portion Mm+ in sufficient numbers to ensure overall e... | 05/28/2002 |
| 6362342 | Triazole compounds and methods of making same The present invention relates to novel triazole compounds of the following formula: ##STR1## wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such ... | 03/26/2002 |
| 6359141 | Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula ##STR1## wherein A is the no... | 03/19/2002 |
| 6342513 | Oxazolidinone antibacterial agents having a thiocarbonyl functionality The present invention provides compounds of Formula 1: ##STR1## or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.... | 01/29/2002 |
| 6329523 | Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou... | 12/11/2001 |
| 6265584 | Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula ##STR1## wherein A is the no... | 07/24/2001 |
| 6262099 | 3-(substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of ... | 07/17/2001 |
| 6262084 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions the... | 07/17/2001 |
| 6248901 | Heterocyclic vinyl ethers The compounds of the formula ##STR1## wherein R signifies halogen or lower alkyl; n signifies 0-3; R1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substitu... | 06/19/2001 |
| 6080772 | Thiazole compounds and methods of modulating signal transduction The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or regulate signal transduction by inhibiting protein tyrosi... | 06/27/2000 |
| 6077954 | Substituted heterocyclic compounds Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear... | 06/20/2000 |
| 6063928 | 5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr... | 05/16/2000 |
| 6022937 | Polyether polyols based on triazole group containing compounds and a process for their production This invention relates to novel polyether polyols and to a process for their production. These polyether polyols are prepared by forming a polyhydroxyl group containing component in a first step by the reaction of a triazole-group containing compound with... | 02/08/2000 |
| 6008368 | Pharmaceutical compositions for treatment of circulatory disorders using N-substituted (-imidazolyl-toluyl) pyrrole aniotensin II antagonists Pharmaceutical compositions comprising a compound selected from a class of N-substituted (-imidazolyl-toluyl)pyrrole compounds are described for use in treatment of circulatory disorders. Compositions of particular interest comprise angiotensin II ... | 12/28/1999 |
| 5981560 | Triazole antifungal agents An antifungal compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl substituted with 1 to 3 substituents each independ... | 11/09/1999 |
| 5972982 | Heteroaryl-substituted deoxy glycerols and antibacterial and antiviral compositions containing the same Heteroaryl-substituted deoxy glycerols represented by the general Formulas Ia, Ib and Ic: ##STR1## wherein: X is oxygen (--O--) or sulfur (--S--); R is substituted or unsubstituted straight or branched chain C1-30 alkyl or alkenyl, pr... | 10/26/1999 |
| 5872259 | Process for separating a substance from an aggregate mixture A process for separating a desired substance from an aggregate mixture is disclosed.... | 02/16/1999 |
| 5861516 | Process for preparing an antifungal azole with hydrazino and amidrazone intermediates A process for preparing an antifungal azole compound of formula (I) by reacting an epoxide with hydrazine to from a hydrazino compound which is subsequently reacted with an iminoether. The amidrazone product is subsequently reacted with an orthoformate to... | 01/19/1999 |
| 5856350 | 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as antidepressants This invention relates to the treatment of depression by administration of novel 3-(Rn -phenyl)-1,4-dialkyl-1,2,4-triazolium salts of the formula ##STR1## wherein R is halogen, trifluoromethyl, C1-4 lower alkyl or C1-4 | 01/05/1999 |
| 5814651 | Catechol diethers as selective PDEIV inhibitors This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDEIV and in the treatment of AIDS, asthma, br... | 09/29/1998 |
| 5792780 | Azole compounds, their production and use The present invention provides an azole compound represented by the formula (I): ##STR1## , wherein Ar is an optionally-substituted phenyl group; R1 and R2 are, the same or different, a hydrogen atom or a lower alkyl group,... | 08/11/1998 |
| 5786375 | Hydroxyethyl-azolyl derivatives Hydroxyethyl-azolyl derivative of the formula (I): ##STR1## in which x represents hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, z represents halogen, alkyl having 1 to 4 carbon atoms, halogenoalkyl having 1... | 07/28/1998 |
| 5770741 | Process for cylopropane derivatives The invention provides a process for the preparation of a compound of the general formula (I): ##STR1## wherein X, Y and R1 to R7 are as defined. In the process, the olefinic analog of the compound of general formula (I) is trea... | 06/23/1998 |
| 5760067 | Halogen alkenyl azolyl microbicides Novel halogenoalkenyl-azolyl derivatives of the formula ##STR1## in which R1 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, optionally substituted aryl or represents optionally ... | 06/02/1998 |
| 5700824 | Triazole derivatives, insecticide, acaricide and methods thereof The invention provides a triazole derivative represented by a general formula ##STR1## (wherein R1 is an alkyl group, X is a hydrogen atom, a halogen atom or an alkyl group, n is an integer of 1-5, Y is a halogen atom, a nitro group o... | 12/23/1997 |
| 5646293 | Preparation of N-alkenylazoles A process for preparing N-alkenylazoles of the general formula I ##STR1## where X is CH--R6 or nitrogen, R1 and R2 are hydrogen or C1 - to C8 -alkyl, R3,R4,R5 and R6 | 07/08/1997 |
