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| Number | Title | Issue Date |
| 7250412 | PH sensitive prodrugs of 2,6-Diisopropylphenol The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylpheno... | 07/31/2007 |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7169929 | Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor The present invention relates to a novel diaryl 1,2,4-triazole derivative of the following formula (1) as a highly selective cyclooxygenase-2 inhibitor, wherein R1, R2, R3, R4, R5, W and A is as defined in this ... | 01/30/2007 |
| 7109203 | Sulfonamide derivatives Sulfonamide derivitives of the formula I wherein R1-R6 are as defined in the description, processes for their production, their use as pharmaceuticals, particularly for use in the treatment or prevention of diseases in which bradykinin B1 ... | 09/19/2006 |
| 7019144 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same A 1,2,4-Triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided. ... | 03/28/2006 |
| 6987112 | Organic compound having cyano group and insecticides/miticides The present invention is directed to compounds represented by Formula (1); wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions characterized by comprisi... | 01/17/2006 |
| 6969727 | Heterocyclic aromatic compounds useful as growth hormone secretagogues Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic a... | 11/29/2005 |
| 6960600 | Azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar1, Ar3, A, R1, R5, R6, R7 and B are such as defined in the description, their preparation method and their use ... | 11/01/2005 |
| 6946562 | Synthesis of peptoid substituted azole compounds Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product fro... | 09/20/2005 |
| 6946460 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides The invention concerns novel azole or triazole derivatives of formula (I), wherein X, Ar1, Ar2, Ar3, A, B, and R1 are as defined herein, their preparation method and their use as fungicides. | 09/20/2005 |
| 6933390 | Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur... | 08/23/2005 |
| 6927217 | HIV protease inhibitors The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development o... | 08/09/2005 |
| 6881847 | Process for the synthesis and recovery of nitramines A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate. ... | 04/19/2005 |
| 6849636 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 02/01/2005 |
| 6803380 | 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them 5-aryl-1H-triazole compounds of the formula are potent and selective COX-2 inhibitors. The invention further relates to pharmaceutical compositions containing these compounds. ... | 10/12/2004 |
| 6706743 | β3 adrenergic receptor agonists and uses thereof The instant invention provides β3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and ... | 03/16/2004 |
| 6646009 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof N-(Aryl)-2-arylethenesulfonamides and pharmaceutically acceptable salts and compositions thereof are useful as antiproliferative agents, including, for example, anticancer agents. They are also useful as radioprotective agents.... | 11/11/2003 |
| 6603018 | Process for the synthesis and recovery of nitramines A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate.... | 08/05/2003 |
| 6589914 | Dihalopropene compounds, insecticidal/acaridcidal agents containing same, and intermediates for their production The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.... | 07/08/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6465650 | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids The invention provides a processes for the preparation of a compound of Formula I, or a salt thereof ##STR1## wherein PG is a urethane- or trityl-type protective group; X is NH, O, or S; Y is CH2, O, or NH; and B' is a base customary in nucleot... | 10/15/2002 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6448293 | Diphenyl ether compounds useful in therapy A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein; R1 and R2, which may be the same or different, are hydrogen, C1 -C6 alkyl, (CH2)m... | 09/10/2002 |
| 6441177 | Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.... | 08/27/2002 |
| 6410736 | Biaryl ether derivatives useful as monoamine reuptake inhibitors The present invention relates to compounds of formula I, ##STR1## and to their pharmaceutically acceptable salts. Compounds of formula I exhibit activity as serotonin, norepinephrine, and dopamine reuptake inhibitors and can be used in the treatment of ce... | 06/25/2002 |
| 6329523 | Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear grou... | 12/11/2001 |
| 6313312 | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.... | 11/06/2001 |
| 6306880 | Triazole antifungal agent A triazole compound having the formula: ##STR1## wherein Ar1 represents a phenyl group which may be substituted; Ar2 represents a phenyl group which may be substituted; R0 represents a hydrogen atom or a lower alkyl; R | 10/23/2001 |
| 6300357 | Triazole antifungal agent A triazole compound having the formula: ##STR1## wherein Ar1 represents a phenyl group which may be substituted, Ar2 represents a heterocyclic group which may be substituted, R0 represents a hydrogen atom or a lower alkyl;... | 10/09/2001 |
| 6265426 | Triazole derivatives The present invention relates to triazole and imidazole derivatives of formula I and to their pharmaceutically acceptable acid addition salts. These compounds are NMDA receptor subtype blockers and are useful for the treatment of diseases related to the N... | 07/24/2001 |
| 6262099 | 3-(substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds 3-(Substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of ... | 07/17/2001 |
| 6255327 | Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) ##STR1## wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for prep... | 07/03/2001 |
| 6096774 | Energetic nitramine-linked azoles and hydroxylammonium salts as oxidizers, intiators and gas generators Novel compounds are provided having the structural formula R[--N(NO2)--L--R1 ]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high ... | 08/01/2000 |
| 6096766 | 3-benzylaminopiperidines as tachykinin receptor antagonists The present invention relates to certain 3-benzylaminopiperidines which are tachykinin receptor antagonists and are useful in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.... | 08/01/2000 |
| 6080772 | Thiazole compounds and methods of modulating signal transduction The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or regulate signal transduction by inhibiting protein tyrosi... | 06/27/2000 |
| 6077813 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I) ##STR1## , wherein Z, R1, R2 and R3 are as defined by the specification, which are useful herbicidal agents.... | 06/20/2000 |
| 6075143 | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids There are described N-ethylglycine derivatives of the formula I ##STR1## in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH2, NH or O, and B' are bases customary in ... | 06/13/2000 |
| 6063928 | 5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr... | 05/16/2000 |
| 6057353 | Triazolyl-mercaptides and their use as microbicides Triazoyl mercaptides of the formula (I) ##STR1## in which M is an alkaline metal cation, an equivalent of an alkaline earth cation, an equivalent of a copper zinc, iron or nickel cation or an ammonium cation and R1 is various radicals, a p... | 05/02/2000 |
