Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein....
|5132316||Heterocyclic azabicyclic compounds for enhancing acetylcholine function|
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which X represents R1 OOC-- in which R1 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl; R2 O-- in which R
|5120861||Diazirine derivatives of aromatic heterocyclic compounds|
Compounds of the formula ##STR1## in which Het represents an optionally substituted aromatic heterocycle having a sulphur or oxygen hetero atom and attached via a ring carbon atom, and X is halogen, alkyl, alkaryl, cyano, alkoxy, mono- or di-alk...
|5110986||Synthesis of N-t-alkyl-1,2-diacylhydrazines|
This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst. Preferably, the 1,3,4-oxadiazole is a 2,5-disubstituted-1,...
|5110821||1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents|
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarb...
A novel process for producing -[(dialkylamino)substituted-methylene]ଲ-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R1 and R2 are defined in the specification by reacting a substituted iso...
Novel 1,6-diaza [4.4] spirodilactams having heterocyclic-containing substituents on each spiro ring nitrogen atom are produced by reaction of a heterocyclic-substituted primary amine compound and a spirodilactam precursor selected from 4-oxoheptanedioic a...
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents --CH2 --Z where Z is a group ##STR2## in which Q represents a 3-membered divalent r...
|5081142||Derivatives of 1-hydroxy-1,2,4-triazole and fungicides and growth regulators containing them|
Compounds of the formula I ##STR1## where Ar is unsubstituted or substituted phenyl, pyridyl, thienyl or napthyl, R1 is hydrogen or CN, R2 is unsubstituted or substituted aryl, hetaryl, alkyl or cycloalkyl, or is unsubstituted o...
|5073563||Alkoxycoumarins substituted by a heterocyclic radical, their preparation and therapeutic agents containing these compounds|
An alkoxycoumarin substituted by a heterocyclic radical, of the formula ##STR1## Het is one of the following heterocyclic radicals: where X is oxygen or sulfur....
|5066656||Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives|
(6,7-dihydro-5H-pyrrolo[1,2-c]imidazolyl-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridinyl-5-yl) substituted 1H-benzotriazole derivatives, compositions containing the same and methods of treating estrogen dependent disorders....
|5061311||Substituted triazolinone herbicides and plant growth regulators|
Novel herbicides and plant growth regulants of the formula ##STR1## in which R1 represents hydrogen alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, alkoxyalkyl, alkoxy, cycloalkylalkyl or cycloalkyl, or represents...
|5059614||Novel isoxazole and isoxazoline compounds with anticonvulsant activity process for their preparation and therapeutic composition containing them|
The object of the invention are anticonvulsant heterocyclic compounds of general formula: ##STR1## in which R1 and R2 is each selected from C1 -C4 alkyl, phenyl, benzyl, trifluoromethyl or halogen, R3
|5051438||Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use|
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2; R1 is alkyl of 1 to 4 carbon atoms; R2
|5051409||2-Aminodecalin derivatives and their use|
2-Aminodecalin derivatives of the formula I ##STR1## where R1, R2 and R3 are H or methyl, A is H, OH, O-alkylcarbonyl, O-benzoyl or O-CH3, R4 is H, cyclopropyl, alkyl, alkenyl, or alkynyl, R5 is...
|5047417||Butenoic or propenoic acid derivatives|
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydrogen or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phe...
This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H
|5043454||Crop protection agents based on 1-aryl- or 1-hetarylimidazolecarboxylic esters|
1-Aryl- and 1-hetarylimidazolecarboxylic esters of the general formulae Ia and Ib ##STR1## where R1 is halogen or substituted or unsubstituted C1 -C4 -alkyl; R2 is substituted or unsubstituted C1...
|5034047||Cyclohexenone derivatives and their use as herbicides|
Cyclohexenone derivatives of the general formula I ##STR1## where the substituents have the following meanings: R1 : substituted or unsubstituted C1 -C6 -alkyl, C3 -C6 -alkenyl or C3 -...
Substituted hydroxylamines of the formula ##STR1## in which R1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis....
|5030654||Glutaramide diuretic agents|
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5- or 6-membered carbocycyclic ring and is locate...
|5026848||Novel generation of heteroaryloxyalkyl heterocycles with antipicornaviruses activities|
A heteroaryloxyalkylheterocyclic derivative of the Formula I: R--(CH2)n --O--R1 I is provided wherein: R is a non-fused azole moiety; n is 5, 6, 7 or 8; and R1 is a non-fused or fused substituted azol...
Novel compounds having an affinity for 5-hydroxytryptamine receptors of the formula ##STR1## in which R1 stands for H, alkyl, aralkyl or heteroarylalkyl, X stands for H, OCH3, OH, SCH3, halogen, CN or CONH2, Y s...
Herbicidal 1-phenylpyrroles of the formula ##STR1## wherein each R1 represents methyl or together form a tetramethylene group, R2 represents hydrogen, C1-6 alkyl, cyclopropylmethyl, C1-4 alkoxy-C1-2
|5015644||Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds|
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood...
Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are usef...
|5001138||Novel heterocyclic compounds|
Novel insecticides of the formula ##STR1## in which n is 0 or 1, X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R9 variously represent hydrogen or specified org...
|4994474||Alkyl- or aryl-aminoalkoxy-benzene-sulfonyl indoles|
The present invention relates to aminoalkoxyphenyl derivatives of formula: ##STR1## and its N-oxide and pharmaceutically acceptable salts, in which: B represents a--S--, --SO-- or --SO2 -- group, R1 and R2, which are ident...
|4992421||Luteinizing hormone releasing hormone antagonist|
The present invention relates to novel luteinizing hormone releasing hormone antagonists ##STR1## The invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds for suppressing levels of sex ...
|4990668||Optically active aryloxypropanolamines and arylethanolamines|
Described is a process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula ##STR1## wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl, or WB wherein W...
|4987146||N-hetaryl imidazole derivatives|
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R3 represents hydrogen, a straight or branched C1-6 -alkyl group, or ...
|4968691||Heterocyclo-substituted azabicyclo muscannic agonists|
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which X represents a group ##STR2## in which p represents an integer of 2 to 4; r represents an integer of 1 or 2; s represents 0 or 1; and A represents a 3-mem...
|4956356||Pesticidal 3-substituted 1-nitro-2-imino-1,3-diazacycloalkanes|
Pesticidal 3-substituted 1-nitro-2-imino-1,3-diazacycloalkanes of the formula ##STR1## in which n stands for the numbers 0 or 1, R1 stands for a five- or six-membered heterocyclic group which contains 1, 2, 3 or 4 nitrogen atoms and/or one...
|4952700||Preparation of isoxazolines and isoxazoles|
A process for forming isoxazolines or isoxazoles by contacting, in the presence of base, a nitro compound, a cyclic anhydride and a dipolarophile. The dicarboxylic acid is readily regenerated to be again reused as the dehydrating agent of additional nitro...
|4945164||1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof|
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarb...
|4939268||4-(meth)acrylamidomethyl)-pyrazoles and -isoxazoles, their preparation and their use|
Novel 4-[(meth)acrylamidomethyl]-pyrazoles and -isoxazoles of the general formula ##STR1## where R is hydrogen or methyl, R1 is hydrogen, methyl or ethyl, R2 and R3 may be identical or different and are each alkyl of ...
|4933464||Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles|
A one-step process to form 3-phenylisoxazolines and 3-phenylisoxazoles by contacting a benzyl halide, a nitrite and an olefin or acetylenic compound, respectively, in the presence of a phase transfer agent....
|4933338||Benzimidazolesulfonamides and their application as drugs|
Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula I: ##STR1## and their pharmaceutically acceptable salts, especially those of the formula in which: Z1 to Z4 represent...
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R1 and R2, which are the same or different, are H or an optionally substituted hydrocarbon group or R1 and R2 together...
|4923889||1,2-diamino compounds, process for their preparation and pharmaceutical compositions containing them|
Compounds are disclosed, including 2-diethylamino-3-isobutoxy-N-phenyl-N-2-furanyl-methyl-propylamine and compounds of the formula: ##STR1## wherein R1 is an iso-C4 -C6 -alkyl radical; A is a valency bond or a st...