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| Number | Title | Issue Date |
| 7893273 | Preparation of N-substituted isothiazolinone derivatives Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II) or N,N′-bis-substituted 3,3′-dithiodipropionamides of formula (III)... | 02/22/2011 |
| 7790902 | Isothiazole derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 | 09/07/2010 |
| 7442240 | Alkoxylpropylisothiazolinone and preparation method and use thereof An alkoxylpropyl isothiazolinone of formula: C6H6Cl2NO2SR, in which R is CH3, CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2 | 10/28/2008 |
| 7429667 | Phenylamino isothiazole carboxamidines as MEK inhibitors The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones. ... | 09/30/2008 |
| 7405218 | Isothiazole derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein.... | 07/29/2008 |
| 7402678 | Multifunctional amine capture agents Multifunctional compounds having acylsulfonamide amine-reactive groups are described that can be used for the capture of amine containing materials. ... | 07/22/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7276602 | Isothiazole derivatives useful as anticancer agents The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2 are as defined herein. The inv... | 10/02/2007 |
| 7253198 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elev... | 08/07/2007 |
| 7169933 | N-sulfonylaminocarbonyl containing compounds Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 01/30/2007 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7008545 | Synergistic biocidal mixtures Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective amount of a nitrogenous compound activated by an oxidant and at least on... | 03/07/2006 |
| 6989451 | Heterocyclic compounds and uses thereof Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK and/or ERK). Consequently, particularly preferred methods include trea... | 01/24/2006 |
| 6927216 | Cyclic sulfonyl compounds as inhibitors of metalloproteases The present application describes novel cyclic sulfonyl derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms select... | 08/09/2005 |
| 6852716 | Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmac... | 02/08/2005 |
| 6833370 | Heterocycle substituted aminoazacycles useful as central nervous system agents Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3 I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said comp... | 12/21/2004 |
| 6831091 | Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide and method of production The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide having the f... | 12/14/2004 |
| 6828276 | Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic... | 12/07/2004 |
| 6809107 | Neurotrophic pyrrolidines and piperidines, and related compositions and methods This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders... | 10/26/2004 |
| 6806369 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 10/19/2004 |
| 6759423 | 4-Hydroxyisothiazole compounds The present invention relates to the use of 4-hydroxyisothiazole compounds as antimicrobially active substances, certain new 4-hydroxyisothiazole compounds and a process for their preparation. ... | 07/06/2004 |
| 6750346 | Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for example, in the fields of medicine, pharmaceutics and in the areas of life... | 06/15/2004 |
| 6746989 | Substituted benzoylpyrazoles as herbicides The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), ... | 06/08/2004 |
| 6740759 | Method for producing 2-alkyl-4-isothiazoline-3-one Chlorinating agent is reacted with a compound represented by formula (I) (wherein R represents C1 to C8 alkyl groups or aralkyl groups) or a compound represented by formula (II) ... | 05/25/2004 |
| 6696475 | Substituted phenyl derivatives, their preparation and use The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.... | 02/24/2004 |
| 6670385 | -phenyl-ଲketosulfone The present invention relates to novel aryl-substituted S(O)m cycles of the formula (I) ##STR1## in which F1, F2, G, V, W, X, Y, Z and m are each as defined in the description, to processes for their preparation and to the... | 12/30/2003 |
| 6593349 | Bisarylamines as potassium channel openers Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides bisarylamines, compositions... | 07/15/2003 |
| 6583291 | Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby A safe and economical process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole. This process comprises refluxing a disodium or dipotassium salt of 3-hydroxy-5-mercapto-4-isothiazole carbonitrile in an aqueous solution of sodium or po... | 06/24/2003 |
| 6566382 | Stabilized isothiazolone-containing compositions The present invention relates to isothiazolone-containing compositions comprising a) 3-isothiazolone compounds; b) a metal nitrate; c) magnesium chloride; d) at least one compound selected from the group consisting of iodic acid, periodic acid, an iodate ... | 05/20/2003 |
| 6548526 | Isothiazole derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein. The invention also r... | 04/15/2003 |
| 6534076 | Stabilized isothiazolone compositions and methods of stabilization of isothiazolone The present invention relates to stabilized isothiazolone compositions and methods of stabilization of isothiazolone, more particularly, to stabilized isothiazolone solutions comprising (a) an isothiazolone composition, (b) sulfuric acid, and (c) solvent.... | 03/18/2003 |
| 6531604 | Benzothiepine derivatives, their production and use The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/11/2003 |
| 6511673 | Microbicidal composition Microbicidal compositions containing selected ratios of a non-halogenated 2-alkyl-3-isothiazolone and one or more (C1 -C7) esters of para-hydroxybenzoic acid are disclosed as improved formulations for controlling microbial growth. In... | 01/28/2003 |
| 6506904 | Method of preparing N,N'-disubstituted-3,3'-dithiodipropionamide and method of preparing substituted 3-isothiazolone by using the same A method of preparing N,N-disubstituted 3,3'-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropi-onamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and... | 01/14/2003 |
| 6479701 | Method of preparing N,N'-disubstituted-3,3'-dithiodipropionamide and method of preparing substituted 3-isothiazolone by using the same A method of preparing N,N-disubstituted-3,3'-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropionamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and ... | 11/12/2002 |
| 6380214 | Heterocyclic derivatives useful as anticancer agents The present invention relates to compounds of the formula 1 ##STR1## and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, X, X1, R1, R2 and R3 are as defined herein as it relates t... | 04/30/2002 |
| 6376680 | Process for the preparation of 3-isothiazolone mixture and composition comprising the mixture An impurity-free biologically active mixture of 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one, which is useful as a biocide in various products, can be prepared by reacting N-methyl-3-mercaptopropionamide or N,N'-dimethyl-3... | 04/23/2002 |
| 6358983 | Heterocyclically substituted -hydroxycarboxylic acid derivatives, method for producing the same and their use as endothelin receptor antagonists The present invention relates to carboxylic acid derivatives of the formula I ##STR1## the substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.... | 03/19/2002 |
| 6355672 | Benzothiepin derivatives, process for the preparation of the same and uses thereof The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/12/2002 |
