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| Number | Title | Issue Date |
| 8093397 | Activators for oligonucleotide synthesis A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The 1,1-dioxo-1,2-dihydro-1... | 01/10/2012 |
| 7087710 | Polymeric surfactants derived from cyclic monomers having pendant fluorinated carbon groups A fluorine containing polymer which acts as a wetting, flow or leveling agent, and has at least one polar group. The polymer has at least one pendant or ether side chain containing from about 1 to about 20 carbon atoms with at least 25% of the hydrogen atoms being r... | 08/08/2006 |
| 6909017 | Method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol as a saccharinate from a mixture of the diastereomers (1SR,2)RS-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and (1SR-2RS... | 06/21/2005 |
| 6605409 | Positive resist composition A positive resist composition comprising (A) a compound generating a specific sulfonimide compound by irradiation with an actinic ray or a radiation and (B) a resin having a group, which is decomposed by the action of an acid to increase the solubility of... | 08/12/2003 |
| 6518281 | Immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.... | 02/11/2003 |
| 6410485 | Saccharin-5-carbonyl derivatives with herbicidal effect The present application relates to saccharin-5-carbonyl derivatives of the formula I ##STR1## in which the substituents have the following meanings: L is C1 -C6 -alkyl, C1 -C6 -alkoxy; Z is C1 -C6 | 06/25/2002 |
| 6075041 | Cyclic amides Cyclic amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 3-phenyl-3-(1-oxoisoindolin-2-yl)propionamide.... | 06/13/2000 |
| 6057350 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ... | 05/02/2000 |
| 6048999 | N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends This invention provides sweetener blends comprising N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester and another sweetener. The sweetener blends of this invention exhibit isobole synergy.... | 04/11/2000 |
| 5981758 | Preparation of saccharincarbonyl halides A process for preparing saccharincarbonyl halides of the formula 1 ##STR1## where: X is halogen, R1, R2 are each hydrogen, C1 -C6 -alkyl, C3 -C8 -cycloalkyl, C1 -C4 -a... | 11/09/1999 |
| 5637722 | Ester syntheses and transesterifiable xanthate reactants therefor "Esters" are synthesized by reacting a nucleophile with a propargyl xanthate advantageously having the formula (I): R3 --C.tbd.C--CR1 R2 --S--CS--Y--R (I) in the presence of at least one acid, Bronsted or otherwise, and at ... | 06/10/1997 |
| 5487846 | Rust inhibitor A general-purpose organic rust initiator which can effectively prevent corrosion of metals comprising a compound of formula (1): ##STR1## wherein R1 is a perfluoroalkyl group having 1 to 6 carbon atoms; R2 is a hydrogen atom or ... | 01/30/1996 |
| 5385923 | 2-saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors 4-R4 --R5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 --R5 -2-halomethylsaccharin with an aryl or aryloxyacetic acid in the p... | 01/31/1995 |
| 5380737 | Saccharin derivative proteolytic enzyme inhibitors Compounds having the structural formula ##STR1## wherein L is N, O or SOn wherein n is 0, 1 or 2; L-R1 is a leaving group, H-L-R1 is the conjugate acid thereof and, when L is N, H-L-R1 has a pKa value... | 01/10/1995 |
| 5362410 | Multifunctional ashless dispersants The incorporation of the heterocyclic saccharin functionality into the alkenylsuccinimide dispersant structures via the Mannich alkylaminoalkylation procedure provides a class of ashless non-phosphorus dispersants with multifunctional antiwear, antioxidan... | 11/08/1994 |
| 5296496 | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof 4-R1 -R2 -R3 -2-Saccharinylmethyl and 4,7-C-4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates of formulas I and IIA respectively herein, useful in the treatment of degenerative diseases, and ... | 03/22/1994 |
| 5264032 | Pigment preparations Pigment preparation essentially comprising a) at least one pigment from the class of azo, anthrapyrimidine, anthanthrone, quinacridone, perinone, diketopyrrolopyrrole, dioxazine, flavanthrone, indanthrone, isoindolinone, isoviolanthrone, perylene, phthalo... | 11/23/1993 |
| 5034534 | Process for producing saccharin, saccharin analogues or their salts This invention concerns a new process for the catalytic carbonylation of certain aryl halides or aryl tosylates to amides by use of a complex of palladium and at least one ligand. More specifically, the invention concerns carbonylation of halogenoaromatic... | 07/23/1991 |
| 4960781 | Fungicidal disazolyl-hydroxyalkyl derivatives Fungicidal bisazolyl-hydroxyalkyl derivatives of the formula ##STR1## in which Ar stands for optionally substituted aryl, X stands for a grouping --CH2 CH2 --, --OCH2 --, --SCH2 -- or --SH.dbd.CH--, Y stands for... | 10/02/1990 |
| 4855145 | Aluminum salt of saccharin The aluminum salt of saccharin and a method for its preparation are disclosed. Chewing gum compositions comprising the novel salt are prepared.... | 08/08/1989 |
| 4849438 | 1,2-benzoisothiazol-3(2H)-one 1,1-dioxide, ion(1-),2-hydroxy-N,N,N-trimethyl-ethanaminium which is plant protection agent for control of fungi and bacteria 1,2-benzoisothiazol-3(2H)-one, 1,1-dioxide, ion(1-),2-hydroxy-N,N,N-trimethyl-ethanaminium represented by the following formula (I): ##STR1## is found to have great utility as an effective component in plant protection agents for control of fung... | 07/18/1989 |
| 4845098 | Saccharine salts of substituted hydroxypropylamines, compositions and use Fungicidal saccharine salts of substituted hydroxypropylamines of the formula ##STR1## in which R1 is optionally substituted phenyl, phenoxy, phenylthio, phenylalkyl, phenoxyalkyl, or phenylthioalkyl, or optionally substituted cyclohe... | 07/04/1989 |
| 4829063 | Saccharine salts of substituted amines Fungicidally active novel saccharine salts of substituted amines of the formula ##STR1## in which A represents in each case optionally substituted 2-decahydronaphthyl or ଲ-naphthyl and R1 and R2 independently of one anothe... | 05/09/1989 |
| 4826836 | Saccharine salts of aminomethyl heterocyclic compounds, compositions and use Fungicidally active novel saccharine salts of aminomethyl heterocyclic compounds of the formula ##STR1## in which R represents optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted thienyl, R1 represents ... | 05/02/1989 |
| 4824844 | Saccharine salts of substituted amines, fungicidal compositions and use Fungicidally active saccharine salts of substituted amines of the formula ##STR1## in which A represents in each case optionally substituted cyclohexyl, cyclohexenyl or phenyl, R1 represents hydrogen or alkyl, R2 represents hydrogen ... | 04/25/1989 |
| 4680410 | Preparation of N- and S-1,2-ethylenically unsaturated organic compounds The invention is a process for the preparation of a N- or S-1,2-ethylenically unsaturated organic compound which comprises (a) contacting a N- or S-silylated organic compound with an aldehyde, wherein the aldehyde has a hydrogen atom bonded to the carbon adjac... | 07/14/1987 |
| 4652577 | Denatonium saccharide, compositions and method of use Denatonium saccharide, which has a vile, bitter taste, is applied to protect an article against gnawing, biting, licking, and feeding by various animals.... | 03/24/1987 |
| 4626325 | Process for the preparation of 4-hydroxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide The specification describes a process for preparing 4-hydroxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide, a sweetener, from 1,2-benzisothiazol-3(2H)-one-1,1-dioxide by anodic oxidation in the presence of trifluoroacetic acid or trifluoromethanesulfonic acid... | 12/02/1986 |
| 4464537 | Preparation of saccharin A process for the preparation of saccharin by reacting an aqueous hydrochloric acid solution of o-methoxycarbonylbenzenediazonium chloride with sulfur dioxide, wherein (a) the aqueous diazonium salt solution is reacted with sulfur dioxide at from 0° to 1... | 08/07/1984 |
| 4404230 | 4-Hydroxy-1,2-Benzisothiazol-3(2H)-one-1,1-dioxides and salts thereof Compounds of the formula ##STR1## wherein R1 is hydrogen or hydroxyl, and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as sweetening agents.... | 09/13/1983 |
| 4323469 | Process for O-acylating phenol derivatives and acylating compositions for this purpose The invention relates to a process for the preparation of carbamic acid phenyl esters of the formula (I) ##STR1## by acylating phenol derivatives of the formula (II) ##STR2## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having... | 04/06/1982 |
| 4315861 | Process for O-acylating phenol derivatives and acylating compositions for this purpose A process is disclosed for preparing a carbamic acid phenyl ester of the formula (I) ##STR1## wherein R is alkyl having 1 to 8 carbon atoms, aryl, cycloalkyl having 5 or 6 carbon atoms, or aralkyl having 7 to 16 carbon atoms, wherein the aryl, c... | 02/16/1982 |
| 4305968 | Modification of biological action of saccharin Members of the urea cycle, i.e. urea, ornithine, arginine and citrulline have been found to reduce the toxicity of saccharin.... | 12/15/1981 |
| 4306071 | 1,4-Bis(2-haloethyl)-1,4-diazabicyclo[2.2.1]-heptane dihydrogen dimaleate and selected salts 1,4-Bis(2'-haloethyl)-1,4-diazabicyclo[2.2.1]-heptane derivatives, such as diperchlorate, dichloride, diacetate, dibenzoate, diascorbate, disalicylate, ditartrate, disaccharin, dihydrogen dimaleate, together with ethyl sulfonate and periodate.... | 12/15/1981 |
| 4259499 | Method for preparing 2-sulfochloride benzoates and the use of same in the preparation of saccharin A method of preparing 2-sulfochloride benzoates which comprises diazotizing any anthranilate to form a 2-diazonium chloride benzoate and thereafter reacting said 2-diazonium chloride benzoate with sulfur dioxide to form a 2-sulfochloride benzoate. The inv... | 03/31/1981 |
| 4158006 | Refining saccharin sodium The disclosure is of a process for refining crude saccharin sodium (saccharin soluble) to remove organic contaminants. The process comprises extraction of an acid solution of the crude saccharin sodium, using methylene chloride to extract the contaminants... | 06/12/1979 |
| 4145349 | Process for the production of saccharine This invention relates to a process of producing saccharin by reacting o-chlorobenzoic acid with sodium sulfite, esterifying it with methanol, and then treating the o-sulfobenzoic acid methyl ester with thionyl chloride as a chlorinating agent, the improv... | 03/20/1979 |
| 4096118 | Process for the production of amino silicate compounds and their resinous products Amino silicate compounds are produced by the chemical reaction of a fine granular silica with amino compounds in the presence of a strong alkali at a suitably elevated temperature, and then the amino silicate compounds are reacted with aldehydes to produc... | 06/20/1978 |
| 4076721 | Process for producing saccharin An o-sulfobenzimide having the formula: ##STR1## is prepared by reacting phosgene with a methylbenzoate-o-sulfonate having the formula: ##STR2## WHEREIN M represents potassium or calcium, n is 1 when M is K and n is 2 when M is Ca, in an in... | 02/28/1978 |
| 4057555 | Process for producing saccharin 1,2-Benzoisothiazole-3-on-1, 1-dioxide having the formula ##STR1## wherein X represents hydrogen, halogen, nitro, lower alkyl or lower alkoxy and Y represents hydrogen, halogen, lower alkyl, or lower alkoxy is prepared by reacting phosgene with an o-... | 11/08/1977 |
