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Class 548/209 - Acyclic chalcogen bonded directly to ring carbon of the thiazole ring


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein acyclic chalcogen (i.e., oxygen, sulfur,
No. of patents: 124
Last issue date: 02/15/2011


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NumberTitleIssue Date
7888514Immobilized 1,2-benzisothiazolin-3-one
The present invention provides novel antimicrobial immobilized 1,2-benzisothiazolin-3-one/zinc oxide (BIT/ZnO) complexes useful as antimicrobial agents because of their resistance to being leached from the substrate to which they are attached. The present invention ...
02/15/2011
7595403Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated ...
09/29/2009
7585980Immobilized 1,2-benzisothiazolin-3-one
The present invention provides novel antimicrobial immobilized 1,2-benzisothiazolin-3-one/zinc oxide (BIT/ZnO) complexes useful as antimicrobial agents because of their resistance to being leached from the substrate to which they are attached. The present invention ...
09/08/2009
7282501Modulators of peroxisome proliferator activated receptors (PPAR)
The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hyperte...
10/16/2007
7232839Benzoisothiazolone compositions
A composition, suitable for topical application to the skin, containing at least one benzoisothiazolone of formula (I): Novel benzoisothiazolones of formula (I) and a method of caring for dry and/or mature skin. ...
06/19/2007
72207663-phenylpropionic acid derivatives
The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or —COO—C1–C4-alkyl group; Y represents NH, N—C1–C10-alkyl, O, or S; X...
05/22/2007
7186839Chemical process for the extraction of 2-hydroxy pyridine derivatives, 2-hydroxyquinoline, and 2-hydroxybenzothiazole
A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali m...
03/06/2007
7169933N-sulfonylaminocarbonyl containing compounds
Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s...
01/30/2007
7125863Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t...
10/24/2006
7105555Stable, neutral pH VOC-free biocidal compositions of 1,2-benzisothiazolin-3-one
What is described herein is a neutral pH, VOC-free biocidal composition of 1,2-benzisothiazolin-3-one which is stable at low temperatures for an extended period of time. The compositions are particularly advantageous in use in protecting latex, paint, coating, cosme...
09/12/2006
RE39265Heteroarylpiperidines, and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound...
09/05/2006
6921739Anti-microbial and oxidative co-polymer
A water-insoluble polymeric oxidizing medium is contemplated that has a plurality of polymerized N-pyridinium vinylbenzyl triiodide or tribromide moieties whose pyridinium rings bear two substituents, R1 and R2, that are independently a hydrido...
07/26/2005
6897230Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof
Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms...
05/24/2005
6670385଱-phenyl-ଲketosulfone
The present invention relates to novel aryl-substituted S(O)m cycles of the formula (I) ##STR1## in which F1, F2, G, V, W, X, Y, Z and m are each as defined in the description, to processes for their preparation and to the...
12/30/2003
6608208Process for the preparation of 1,2-benzisothiazolin-3-ones
A process for making a 2-alkylbenzisothiazolinone which comprises reacting a bisamide of formula ##STR1## in water or an organic liquid containing water with a bisulphite or bisulphite release agent to form a Bunte salt and converting the Bunte salt ...
08/19/2003
6458962Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams
Biologically active sultams are disclosed which have potent anti-HIV activity. Solution methods of syntheses, which use a new catalyst for the asymmetric reduction of a C.dbd.N intermediate, are described. Biological compositions and method of treating ma...
10/01/2002
63765224-hydroxyisothiazole compounds
The present invention relates to the use of 4-hydroxyisothiazole compounds as antimicrobially active substances, certain new 4-hydroxyisothiazole compounds and a process for their preparation....
04/23/2002
6350879Benziso-N (L-histidine methylester)-thiazolone, process for the preparation thereof, and use thereof for RNA polymerase inhibition
The present invention discloses novel benziso-N(L-histidine methylester)-thiazolone compound of the formula 3 useful as a RNA polymerase inhibitor. These compounds are prepared by generating the free amine of the histidine methylester in situ by the addit...
02/26/2002
63507543-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
The present invention relates to novel 3-(cycloalkano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be usefu...
02/26/2002
6319932Oxazolidinones useful as alpha 1A adrenoceptor antagonists
Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment...
11/20/2001
6277987Sulfonylamino acid and sulfonylamino hydroxamic acid derivatives
Compounds of formula ##STR1## wherein W is --OH or --NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)m moiety by a ring nitrogen, --CONR2 ...
08/21/2001
61843872-(1,2-benzisothiazol-3(2H)-ylidene 1,1-dioxide)acetamides negative charge control agents for electrostatographic toners and developers
The invention, in its broader aspects provides an electrophotographic toner having polymeric binder and 2-(1,2-benzisothiazol-3(2H)-ylidene 1,1-dioxide)acetamides as charge control agent. ##STR1## wherein n is 1 or 2; R and R1 are defined in th...
02/06/2001
61749094-aminotetrahydrobenzisoxazole or -isothiazole compounds
The present invention relates to novel 4-aminotetrahydrobenzisoxazoles or 4-aminotetrahydrobenziothiazoles having gamma-aminobutanoic acid (GABA)-uptake inhibiting activity and thus useful in the treatment of analgesia, psychosis, convulsions, anxiety, ep...
01/16/2001
6111105Processes and intermediates for preparing 3-(1-piperazinyl)-1,2-benzisothiazole
The present invention relates to processes for the preparation of 3-(1-piperazinyl)-1,2-benzoisothiazole or its pharmaceutically acceptable salt and to novel intermediates used in the process....
08/29/2000
6040452Process for making benzisothiazolin-3-ones
A process for making a 1,2-benzisothiazolin-3-one by cycling a bisamide precursor under alkaline conditions in the presence of oxygen or an oxygen-release compound in the presence of a nitrogen, sulphur or phosphorus nucelophile. Preferred nucelophiles ar...
03/21/2000
6020358Substituted phenethylsulfones and method of reducing TNF଱ levels
Phenethylsulfones substituted in the position ଱ to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF଱ in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-a...
02/01/2000
5936094Process for the preparation of 1,2-benzisothiazolin-3-ones
A process for making a 2-alkylbenzisothiazolinone which comprises reacting a bisamide of formula ##STR1## in water or an organic liquid containing water with a bisulphite or bisulphite release agent to form a Bunte salt and converting the Bunte ...
08/10/1999
5919941Intermediates for the preparation of sulphonic acid salts of 4-amino-2-cyclopentene-1-carboxylic acid
The present invention relates to intermediates for the preparation of sulphonic acid salts of 4-amino-2-cyclopentane-1-carboxylic acid....
07/06/1999
5863915Substituted 4-arylbutyric acid derivatives as matrix metalloprotease
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein R...
01/26/1999
5827799Compounds and herbicides containing same as active components
An object of the invention is to provide herbicides which are completely selective to crops such as paddy rice, soybeans and cotton and have an excellent herbicidal activity on weeds. The invention relates to ether compounds of the general formula (I) ##S...
10/27/1998
57769633-(heteroaryl)-1-›(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-›(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
07/07/1998
5773626Method for producing 1,2-benzisothiazol-3-ones
A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime...
06/30/1998
5750715Bis›(1,2-benzisothiazol-3(2H)-ylidene 1,1-dioxide)acetates! charge-control agents
Bis›(1,2-benzisothiazol-3(2H)-ylidene 1,1-dioxide)acetates! are disclosed. They have the general structure (I): ##STR1## R is defined in the specification....
05/12/1998
5744609Method for producing alkylsulfinylbenzamides and 1-2 benzisothiazol-3-ones
A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthi...
04/28/1998
5684025Liquid formulations of 1,2-benzisothiazolin-3-one
Liquid formulations of 1,2-benzisothiazolin-3-one, and methods for making such formulations, are disclosed. Formulations according to the invention contain about 1 to 25 percent by weight 1,2-benzisothiazolin-3-one, about 3 to 7 percent by weight of sodiu...
11/04/1997
5663449Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
09/02/1997
5663337Pharmaceutically active benzoquinazoline compounds
The present invention relates to benzoquinazoline thymidylate synthase inhibitors, processes for preparing them and pharmaceutical formulations containing them....
09/02/1997
5654319N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
08/05/1997
56397642-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
06/17/1997
5637710Intermediate compounds in the synthesis of heteroarylpiperidines and piperazines
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
06/10/1997
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