Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7956193 | Intramolecular C-H amination with sulfonyl azides Cobalt (II) complexes of porphyrins are effective catalysts for intramolecular nitrene insertion of C—H bonds with arylsulfonyl azides. The cobalt-catalyzed process can proceed efficiently under mild and neutral conditions in low catalyst loading without the need ... | 06/07/2011 |
| 7714140 | 1,2 Benzoisothiazole derivative, and agricultural or horticultural plant disease- controlling agent A 1,2-benzoisothiazole derivative or a salt thereof is not harmful to a crop and is remarkably effective against agricultural or horticultural plant diseases such as Pyricularia oryzae, Septoria nodorum, Pseudoperonospora cubensis and Colletotrichum orbicu... | 05/11/2010 |
| 7714139 | IDO inhibitors and methods of use Compounds, compositions and methods for the treatment of malignancy are disclosed. ... | 05/11/2010 |
| 7662969 | Efficient aziridination of olefins catalyzed by dirhodium catalysts This invention relates to compositions and methods for achieving the efficient aziridination of organic molecules, especially olefins. More specifically, the invention is directed to a mild, selective, and efficient aziridination protocol that involves catalysis by ... | 02/16/2010 |
| 7649097 | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tetracyclic arylsulfonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel int... | 01/19/2010 |
| 7468439 | Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function Disclosed are sultam compounds of Formula (I) or a pharmaceutically-acceptable salt thereof. Also disclosed are methods of using such compounds in the treatment of at least one nuclear hormone receptor-associated condition,... | 12/23/2008 |
| 7453000 | Substituted oxazolobenzoisothiazole dioxide derivatives method for production and use thereof The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments for lowering blood sugar levels and for prevention and treatment of dia... | 11/18/2008 |
| 7358373 | Cathepsin K inhibitors The present invention provides a compound of the Formula: a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar1, R1, R2, R3, R4, and R | 04/15/2008 |
| 7351732 | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for which an agonist of these receptors is indicated. They a... | 04/01/2008 |
| 7342034 | Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds. ... | 03/11/2008 |
| 7342082 | Soluble polymers as amine capture agents and methods Soluble polymers and methods for the preparation thereof, wherein the polymers of the present invention have pendant acylsulfonamide amine-reactive groups that can be used for the capture of amine containing materials. ... | 03/11/2008 |
| 7309802 | Preparation of isoxazolin-3-ylacylbenzene A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, ... | 12/18/2007 |
| 7220766 | 3-phenylpropionic acid derivatives The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or —COO—C1–C4-alkyl group; Y represents NH, N—C1–C10-alkyl, O, or S; X... | 05/22/2007 |
| 7211592 | Substituted an unsubstituted benzooxathiazoles and compounds derived therefrom The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments. ... | 05/01/2007 |
| 7173043 | Heteroaromate OSC inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vasc... | 02/06/2007 |
| 7169933 | N-sulfonylaminocarbonyl containing compounds Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 01/30/2007 |
| 7160902 | Amide derivatives and methods of their use Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal d... | 01/09/2007 |
| 7161010 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represe... | 01/09/2007 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7094777 | 5-HTreceptor ligands Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions. ... | 08/22/2006 |
| RE39198 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amounts of one of the compounds. The compoun... | 07/18/2006 |
| 7041691 | Compounds for the modulation of PPARγ activity Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 05/09/2006 |
| 6992193 | Sulfonylamino phenylacetamide derivatives and methods of their use Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds o... | 01/31/2006 |
| 6951879 | Heteroaromate OSC inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vasc... | 10/04/2005 |
| 6908492 | 7-nitro-2,1,3-benzoxadiazole and 7-nitro-2,1,3-benzthiadiazole derivatives, as well dyeing agents for keratin fibers containing these compounds The new 7-nitro-2,1,3-benzoxadiazole compounds and 7-nitro-2,1,3-benzthiadiazole compounds of formula (I) are: Dyeing agents for keratin fibers, containing the compounds of formula (I), and methods of dyeing hair with ... | 06/21/2005 |
| 6906070 | Guanidine mimics as factor Xa inhibitors The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are use... | 06/14/2005 |
| 6894172 | Chiral cheating agent and chiral catalyst Chiral chelating agents and chiral catalysts, which are formed from the chiral chelating agents and metal, are described. One chiral chelating agent has a general formula (1) as illustrated below: wherein R represents ... | 05/17/2005 |
| 6869454 | 7-Nitro-2,1,3-benzoxadiazole and 7-nitro-2,1,3-benzthiadiazole derivatives, as well dyeing agents for keratin fibers containing these compounds The new 7-nitro-2,1,3-benzoxadiazole compounds and 7-nitro-2,1,3-benzthiadiazole compounds of formula (I) are: Dyeing agents for keratin fibers containing these compounds and methods of dyeing hair with the dyeing agen... | 03/22/2005 |
| 6858623 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 02/22/2005 |
| 6849620 | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is W0 is a bicyclic moiety and is | 02/01/2005 |
| 6797726 | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same An N-alkoxyalkyl-N,N-dialkylamine derivative represented by the following general formula [1]: wherein the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R3 and R4, whic... | 09/28/2004 |
| 6706663 | Herbicidal 3-heterocyclic substituted benzisothiazole and benzisoxazole compounds There are provided 3-heterocyclic substituted benzisothiazole and benzisoxazole compounds having the structural formula I where Q, X, X1 and Z are defined as in claim 1. Further provided are composition... | 03/16/2004 |
| 6689770 | Aryl sulfonyls as factor Xa inhibitors The present application describes aryl sulfonyls of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.... | 02/10/2004 |
| 6683101 | Bicyclic cyclohexylamines and their use as NMDA receptor antagonists Described are heterocycle-substituted cyclohexylamines of formula (I), and their pharmaceutically acceptable salts thereof. The compounds of the formula (I) are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders... | 01/27/2004 |
| 6669926 | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are usef... | 12/30/2003 |
| 6667405 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): ##STR1## wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to f... | 12/23/2003 |
| 6664411 | Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptab... | 12/16/2003 |
| 6620813 | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (through promoting ... | 09/16/2003 |
| 6605604 | Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R1, R2, R3, R4 represent a hydrogen or an alkyl group, or R1 and R3 together form a cycloalkyl group; R5 | 08/12/2003 |
| 6569879 | Aryloxyacetic acids for diabetes and lipid disorders A class of aryloxyacetic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyper... | 05/27/2003 |
