Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8067611 | Substituted 1-(thiazolyl)-and 1-(isothiazolyl)pyrazol-4-ylacetic acids, processes for their preparation and their use as herbicides and plant growth regulators The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R1, R2, R3, R4, R5 | 11/29/2011 |
| 7671212 | Isothiazole dioxides as CXC- and CC-chemokine receptor ligands Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Sub... | 03/02/2010 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7335775 | Effector conjugates, process for their production and their pharmaceutical use Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjuga... | 02/26/2008 |
| 7326740 | Natural products composites Disclosed are natural products composites protected against the deleterious effects of microorganisms comprising at least one natural product, at least one thermoplastic resin, and an effective amount of an antifungal agent. The composites are further advantageously... | 02/05/2008 |
| 7316851 | Electroluminescent material, electroluminescent element and color conversion filter An electroluminescent element is disclosed, comprising an electroluminescent material and a fluorescent substance emitting light having an emission maximum at the wavelength different from that of light emitted from the electroluminescent material upon absorption of... | 01/08/2008 |
| 7309802 | Preparation of isoxazolin-3-ylacylbenzene A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, ... | 12/18/2007 |
| 7307173 | Pyrroline chromophores Electron acceptor compounds, nonlinear optical chromophores, methods for making the compounds and chromophores, and materials and electro-optic devices that include the chromophores. ... | 12/11/2007 |
| 7301028 | Mitotic kinesin inhibitors The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which com... | 11/27/2007 |
| 7297797 | Pyrrolines The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, A1, A2, R5, R6, R7, R | 11/20/2007 |
| 7273882 | Aminoacetamide acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R | 09/25/2007 |
| 7271184 | Acyclic and cyclic guanidine- and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides Novel pesticides of formula (I) wherein the substituents, R, R1, R2, R2′, T, U, X and Y are as defined in claim 1, are described. Also described are compositions suitable... | 09/18/2007 |
| 7265249 | Enantioselective alpha-fluorination of aldehydes using chiral organic catalysts Nonmetallic, chiral organic catalysts are used to catalyze enantioselective fluorination of enolizable aldehydes. Reaction systems composed of an enolizable aldehyde, an electrophilic fluorination reagent, and a nonmetallic chiral catalyst in the form of an imidazol... | 09/04/2007 |
| 7247720 | Phosphitylation process A process for the phosphitylation of an alcohol or thiol with a phosphitylation agent in the presence of an activator is provided. The activator has the formula: wherein p is 0 or an integer from 1 to 4 and R for... | 07/24/2007 |
| 7244851 | Inhibitors of IAP The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R... | 07/17/2007 |
| 7208169 | Biphenyl carboxamides The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality... | 04/24/2007 |
| 7199133 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors | 04/03/2007 |
| 7186738 | Antibacterial oxalidinones Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl, substituted with: T is for example selected from (TAa1 to TAa12) such... | 03/06/2007 |
| 7186843 | Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th... | 03/06/2007 |
| 7169797 | Protein-tyrosine phosphatase inhibitors and uses thereof The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and... | 01/30/2007 |
| 7157482 | Antibacterial 1,3-oxazolidin-2-one derivatives Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R1; R1 is for example optionally substituted (1-4C)alkyl; Q is for example ... | 01/02/2007 |
| 7129254 | Effector conjugates, process for their production and their pharmaceutical use Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjuga... | 10/31/2006 |
| 7119104 | Activator of peroxisome proliferator-activated receptor delta A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B | 10/10/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7091229 | Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularl... | 08/15/2006 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7078403 | Antiviral agents Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable deriva... | 07/18/2006 |
| 7074870 | Styrene polymers and phenol-triazole type complexes, catalysts, and processes for polymerizing Metal-ligand complexes that are useful as precursors to catalysts for the polymerization of olefins are provided. Certain of the catalysts are particularly effective at polymerizing ethylene and styrene into copolymers having novel properties, including a low molecu... | 07/11/2006 |
| 7064214 | Methods of preparing sulfinamides and sulfoxides This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared. ... | 06/20/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 7041670 | Florfenicol-type antibiotics The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such... | 05/09/2006 |
| 7015225 | Anti-cancer agents and methods Derivatives of retinamide are potent and selective apoptosis-inducing agents. These compounds exhibit antitumor properties and as such can be used in the treatment of cancer and other hyperproliferative disorders. ... | 03/21/2006 |
| 6989451 | Heterocyclic compounds and uses thereof Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK and/or ERK). Consequently, particularly preferred methods include trea... | 01/24/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6982264 | Substituted alcohols useful in treatment of Alzheimer's disease The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are u... | 01/03/2006 |
| 6965004 | Ethylene-styrene copolymers and phenol-triazole type complexes, catalysts, and processes for polymerizing Metal-ligand complexes that are useful as precursors to catalysts for the polymerization of olefins are provided. Certain of the catalysts are particularly effective at polymerizing ethylene and styrene into copolymers having novel properties, including a low molecu... | 11/15/2005 |
| 6958348 | 3-glyoxylamideindoles for treating cancer Disclosed is an anti-cancer compound represented by Structural Formula (I): The variables in Structural Formula (I) are described hereinbelow. Also disclosed is a pharmaceutical composition comprising a pharmaceuticall... | 10/25/2005 |
| 6936630 | Substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is wherein R9, R10, R11 | 08/30/2005 |
| 6933355 | Ethylene-styrene copolymers and phenol-triazole type complexes, catalysts, and processes for polymerizing Metal-ligand complexes that are useful as precursors to catalysts for the polymerization of olefins are provided. Certain of the catalysts are particularly effective at polymerizing ethylene and styrene into copolymers having novel properties, including a low molecu... | 08/23/2005 |
| 6927216 | Cyclic sulfonyl compounds as inhibitors of metalloproteases The present application describes novel cyclic sulfonyl derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms select... | 08/09/2005 |
