Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8148542 | Method for producing crystal polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid A method for producing crystal A of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid by dissolving 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in methanol or a mixed solvent of methanol and water (the volume ratio of methanol... | 04/03/2012 |
| 8063227 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron a... | 11/22/2011 |
| 8008502 | Thiazoline acid derivatives The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated... | 08/30/2011 |
| 7541475 | Substituted thiazoles This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a c... | 06/02/2009 |
| 7402600 | Nitroderivatives of cardiovascular agents Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bi... | 07/22/2008 |
| 7361676 | Solid preparation containing single crystal form There are provided a solid preparation containing a single crystal of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, an excipient and a disintegrating agent, and a method for producing the same. ... | 04/22/2008 |
| 7342032 | Thiazole derivatives having CB-antagonistic, agonistic or partial agonistic activity Computer game systems respond to the spatial state of a pointing device. Changes in the spatial state of a hand held or mobile unit, or plurality of units drive a game scheme maintained in a computer. Position and attitude of the mobile device cause program branchin... | 03/11/2008 |
| 7319150 | Method for preparing styryl pyrazole, isoxazole and isothiazole derivatives The invention concerns a method for synthesizing styryl isoxazole, styryl pyrazole and styryl isothazole derivatives in a synthesis step followed by a recrystallization in a basic alcohol medium. ... | 01/15/2008 |
| 7309714 | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved... | 12/18/2007 |
| 7294718 | Synthesis of a 4-methylthiazole-4(S)-carboxylic acid compound Benzimidates can be reacted with a large number of nucleophiles, leading to a wide variety of products. The present invention discloses a facile synthesis for ethyl 2,4-dihydroxybenzimidate, and ethers and diethers thereof, from 2,4-dihydroxybenzoic acid or 2,4-dibe... | 11/13/2007 |
| 7285670 | Synthesis of substituted thiazoline carboxylic acids A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a subst... | 10/23/2007 |
| 7262183 | Substituted 5-membered n-heterocyclic compounds and their uses for treating or preventing neurodegenerative diseases This invention relates to substituted 5-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, R3, R4, V, W, X, Y, and Z are as defined in t... | 08/28/2007 |
| 7256211 | 8-azaprostaglandin derivatives and medical use thereof The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification)... | 08/14/2007 |
| 7244754 | 2-methylthiazolidine-2,4-dicarboxylic acid and salts thereof for treatment of neurodegenerative diseases The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases... | 07/17/2007 |
| 7241900 | Synthesis of indole thiazole compounds as ligands for the Ah receptor A method of synthesizing aromatic ketone compositions of formula I comprising the step of introducing a double bond into the 5 membered ring of the 4,5-dihydro-1,3-azoles moiety of formula II is disclosed. A method of synthesizing aromatic ketone compositions of for... | 07/10/2007 |
| 7241902 | Allylmercaptocaptopril compounds and uses thereof Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin. ... | 07/10/2007 |
| 7230021 | Potent, simplified derivatives of pateamine A The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim 1. The present invention also provides processes for the prep... | 06/12/2007 |
| 7163952 | Azole compound and medicinal use thereof The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetr... | 01/16/2007 |
| 7153883 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair ... | 12/26/2006 |
| 7126004 | Thiazoline acid derivatives The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated... | 10/24/2006 |
| 7119208 | Anti-sickling agents Compounds for the treatment of sickle-cell disease, and methods for their use are provided. The compounds have a dual mode of action. First, binding of the compounds to hemoglobin increases the oxygen affinity of both normal and sickle hemoglobin. Secondly, binding ... | 10/10/2006 |
| 7105551 | Thiazole derivatives for treating PPAR related disorders The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases ... | 09/12/2006 |
| 7101901 | 2-Methylthiazolidine-2,4-Dicarboxylic acid and salts thereof for the treatment of neurodegenerative diseases The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases... | 09/05/2006 |
| 7081537 | Process for the electrophilic substitution of thiazolidines or oxazolidines A process for preparing α-functionalized thiazolidines or oxazolidines, each of which are oxycarbonyl-functionalized in the 4-position, by adding a base to a reaction mixture comprising an oxycarbonyl-functionalized thiazolidine or oxazolidine and an electrophile a... | 07/25/2006 |
| RE39132 | Thiazoline acid derivatives Phenyl- and pyridyl-substituted thiazoline acid derivatives useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals. ... | 06/13/2006 |
| 6987120 | Pharmaceutical compounds Compounds of their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bi... | 01/17/2006 |
| 6987104 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in th... | 01/17/2006 |
| 6982335 | Synthesis of substituted thiazoline carboxylic acids A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a subst... | 01/03/2006 |
| 6949543 | Amide derivative The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of ami... | 09/27/2005 |
| 6916834 | Preparations and use of an Ah receptor ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester Preparation, use, and structure of endogenous Ah receptor ligand is disclosed. ... | 07/12/2005 |
| 6903119 | Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity ... | 06/07/2005 |
| 6903220 | Synthesis of chiral 2-alkyl amino acids Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves reacting cysteine (or a salt or an ester thereof) and ... | 06/07/2005 |
| 6894170 | Process for the preparation of substituted thiazolines and their intermediates Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from t... | 05/17/2005 |
| 6878828 | Synthesis of 2-alkylcysteine via substituted thiazoline ester Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing a 2-alkylcysteine comprising con... | 04/12/2005 |
| 6867225 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof Wherein R1 and R2 are independently H or C1-3 alkyl or R1 | 03/15/2005 |
| 6815445 | Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes The present invention is directed to a compound of Formula I: wherein A, R1, and R2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, me... | 11/09/2004 |
| 6794515 | Synthesis of 2-alkylcysteine via substituted thiazoline amide Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing 2-alkylcysteine comprising conde... | 09/21/2004 |
| 6780995 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer... | 08/24/2004 |
| 6753431 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined bel... | 06/22/2004 |
| 6699860 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.... | 03/02/2004 |
