|7928243||Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome|
The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided. ...
|7754890||Arylsulfones and uses related thereto|
Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: ...
|7538229||Preparation of thiazoles|
A process for the preparation of a compound of formula I wherein R is a range of organic groups and X is a leaving group which process comprises a) reacting a compound of the formula II
|7439260||7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors|
The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents.
|7365196||Sulphonamido-substituted bridged bicycloalkyl derivatives|
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ...
|7358266||Cyclopropyl and cyclobutyl epothilone analogs|
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and ...
|7348342||Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine|
We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases. ...
|7282512||Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors|
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, inclu...
|7169782||Aryl substituted thiazolidinones and the use thereof|
This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R1 and R2, are defined in the specification. The inve...
|7161011||Preparation of thiazoles|
Described is a process for the preparation of a compound of the formula wherein R is unsubstituted or substituted C1–C12alkyl, C2–C4alkenyl, C2–C4...
|7109223||Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EPreceptor agonists in the treatment of glaucoma|
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a p...
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ...
|6960688||Use of compounds for the elevation of pyruvate dehydrogenase activity|
The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ...
|6956038||Aryl substituted thiazolidinones and the use thereof|
This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R1 and R2, are defined in the specification. The invention ...
|6908939||Biaromatic ligand activators of PPARγ receptors|
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulatin...
|6777434||Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same|
A thiazolidine-4-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein...
|6762198||Dihetero-substituted metalloprotease inhibitors|
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):
The invention relates to compounds of formula (I) in which X represents halogen, and n represents 0, 1 or 2, to a process for their preparations and to their use as nematacides. ...
|6727268||2-thioxothiazole derivative, method for preparing the same, and pharmaceutical composition containing the same|
A 2-thioxothiazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein:
|6723753||Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity|
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle...
|6710045||Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (IV)|
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which m represents integers from 3 to 10, n represents 0, 1 or 2 and Het represents the following, i...
|6610857||Process for the production of dithiazolyl disulfides|
The invention relates to a process for the production of 2,2'-dithiazolyl disulfides by oxidation of 2-mercaptothiazoles with peroxidic compounds in an aqueous suspension in a specific pH range....
|6566381||Hetero-substituted metalloprotease inhibitors|
Heterocyclic substituted compounds having the general structure: ##STR1## which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes....
|6544982||Thrombin receptor antagonists|
A thrombin receptor antagonist having the formula ##STR1## useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non...
|6544931||Substituted heteroaryloxyacetanilides and their use as herbicides|
The invention relates to novel substituted heteroaryloxyacetanilides of the general formula (I), ##STR1## in which n, R, X, and Z are to intermediates for their preparation and to their use as herbicides....
|6531497||Epothilone derivatives and their synthesis and use|
The invention relates to epothilone analog represented by formula (I) wherein (i) R2 is absent or oxygen; "a" can be either a single or double bond; "b" can be either absent or a single bond; and "c" can be either absent or a single bond, with ...
|6528652||Composition and device for detecting leukocytes in urine|
Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. A thiazole ester of the invention is of th...
|6528535||Bicyclic inhibitors of protein farnesyl transferase|
The present invention provide compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable...
Novel benzotriazoles of the formula ##STR1## in which R, X1, X2, X3, X4 and Y have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for the preparation of these...
|6506751||Thiazolidinone compounds useful as chemokine inhibitors|
Disclosed are compounds of the Formula I ##STR1## wherein: Z is C or nothing, provided that when Z is nothing, R3 and R4 are nothing; A is S, S.dbd.O or O.dbd.S.dbd.O; R1 and R2 are independently hydrogen, lower alky...
|6452014||Telomerase inhibitors and methods of their use|
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be...
|6432993||Substituted fused heterocyclic compound|
Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: ##STR1## wherein R1 is a group of the formula (II) or (III): ##STR2## R4 is a substituted phenyl or a pyridyl which may have ...
|6420384||Proton pump inhibitors|
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone targeting moiety and a payload. The payload portion of these inv...
|6413997||3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds|
3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of...
|6410734||2-substituted thiazolidinones as beta-3 adrenergic receptor agonists|
This invention provides compounds of Formula I having the structure ##STR1## wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt the...
|6376489||Cyclic AMP-specific phosphodiesterase inhibitors|
Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as cen...
|6369273||Chemical compounds and their use to elevate pyruvate dehydrogenase activity|
The use of a compound of the formula (I): ##STR1## wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A--B is selecte...
|6369233||Process for the preparation of thiazole derivatives|
The Invention relates to a process for the preparation of a compound of the formula ##STR1## wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a c...
|6346532||Amide derivatives or salts thereof|
##STR1## Amide derivatives represented by general formula (I) or salts thereof wherein each symbol has the following meaning: ring B: an optionally substituted heteroaryl optionally fused with a benzene ring; X: a bond, lower alkylene or lower alkenylene ...
|6335357||Pyrazole derivatives, process for preparing the same, intermediates, and pest control agent containing the same as active ingredient|
A 1-aryl-3-cyano-5-(het)arylalkylaminopyrazole derivative represented by the general formula (1): ##STR1## process of making, intermediate thereof and pesticide therewith....