Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8148540 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medica... | 04/03/2012 |
| 7935828 | Organic semiconductor material, organic semiconductor structure and organic semiconductor apparatus The present invention is directed to the provision of a novel liquid crystalline organic semiconductor material that is highly stable under an film forming environment and, at the same time, can easily form a film, for example, by coating. The liquid crystalline org... | 05/03/2011 |
| 7812172 | Thiazolothiazole derivative A thiazolothiazole derivative is represented by the following Formula (I). In Formula (I), each R1 independently represents a straight chain alkyl group having 3 to 20 carbon atoms, a straight chain alkoxy group having 3 to 20 carbon atoms, a branched alk... | 10/12/2010 |
| 7767824 | Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient Heterocyclic compound represented by the formula I wherein represents or the like; R1 represents hydrogen atom, C1 | 08/03/2010 |
| 7473783 | Bicyclic pyrazolo protein kinase modulators The present invention provides novel bicyclic pyrazolo kinase modulators and methods of using the novel bicyclic pyrazolo kinase modulators to treat diseases mediated by kinase activity. ... | 01/06/2009 |
| 7419993 | Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ... | 09/02/2008 |
| 7393867 | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous system diseases and disorders ... | 07/01/2008 |
| 7300949 | Thiazolopyrazoles and methods of their use This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention. ... | 11/27/2007 |
| 7253154 | Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m... | 08/07/2007 |
| 7153878 | Peroxisome proliferator activated receptor modulators The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I. (Formula I); wherein: (a) R5 is selected from the group consisting of (C1–C6)alkyl, (C | 12/26/2006 |
| 7018997 | Tricyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hy... | 03/28/2006 |
| 6893650 | N2-phenylamidine derivatives The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or diff... | 05/17/2005 |
| 6730793 | Two-photon responsive chromophores containing electron accepting core units Provided are chromophores of the formula Q—(—L—Z)x, wherein x is 2 or 3, wherein Q is selected from the group consisting of wherein L is | 05/04/2004 |
| 6727246 | 1-(aminoalkyl)-3-sulfonylindole-and-indazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides compounds of formula I and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor. ... | 04/27/2004 |
| 6706724 | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfer... | 03/16/2004 |
| 6608070 | 2,3-substituted indole compounds as anti-inflammatory and analgesic agents This invention provides a compound of the following formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, --NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an opt... | 08/19/2003 |
| 6576780 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 06/10/2003 |
| 6566363 | Pyrazole-thiazole compounds, pharmaceutical compositions containing them Pyrazole-thiazole compounds that modulate and/or inhibit the activity of cyclin-dependent kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating cyclin-dependent diseases to modulate and/or inhibit ... | 05/20/2003 |
| 6479527 | Bicyclic pyrrole derivatives as MCP-1 inhibitors A pharmaceutical composition comprising a compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1 and wherein A and B together form an optionally substitu... | 11/12/2002 |
| 6461747 | Heterocyclic compounds, materials for light emitting devices and light emitting devices using the same Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L.paren open-st.A)m... | 10/08/2002 |
| 6127395 | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; the W ring is an optionally substituted aryl or heteroaryl group; and ##STR2## represents an optiona... | 10/03/2000 |
| 6096771 | Isoxazole derivatives An isoxazole compound having the following formula: ##STR1## wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbam... | 08/01/2000 |
| 5998408 | Triterpene derivatives with immunosuppressant activity The compounds of Formula I ##STR1## are useful as immunosuppressive agents.... | 12/07/1999 |
| 5990145 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I, A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compound... | 11/23/1999 |
| 5851425 | Imidazothiazoles Compounds of the general formula ##STR1## have a pronounced tendency to form liquid crystalline S (smectic) phases. Thus, optically inactive compounds of the formula I also have a tilted smectic phase, in particular an SC phase, in additio... | 12/22/1998 |
| 5824677 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 10/20/1998 |
| 5733648 | Organic compounds suitable as reactive diluents, and binder precursor compositions including same Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety d... | 03/31/1998 |
| 5719170 | Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases ... | 02/17/1998 |
| 5703093 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune res... | 12/30/1997 |
| 5693460 | Silver halide photographic elements containing dioxide compunds a stabilizers This invention provides a silver halide photographic element comprising a silver halide emulsion in reactive association with a dioxide compound represented by the following formula: ##STR1## wherein b is C(O), C(S), C(Se), CH2 or (CH2)2; and R1... | 12/02/1997 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5637725 | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; the W ring is an optionally substituted aryl or heteroaryl group; and ##STR2## represents an optiona... | 06/10/1997 |
| 5637724 | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; the W ring is an optionally substituted aryl or heteroaryl group; and ##STR2## represents an optiona... | 06/10/1997 |
| 5591762 | Benzimidazoles useful as angiotensin-11 antagonists Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8... | 01/07/1997 |
| 5521213 | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of ... | 05/28/1996 |
| 5350857 | Thiazolo[5,4-D]thiazsole Color-formers This invention relates to improved imaging systems based on the formation of green-yellow colored coordination compounds of transition metals with certain ligands. The formation of colored coordination compounds can be employed to generate images and is i... | 09/27/1994 |
| 5350760 | Aza-5,5-fused hetrocyclic acids as leukotriene antagonists Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spas... | 09/27/1994 |
| 5240938 | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##... | 08/31/1993 |
| 5194177 | Optically active compound, liquid crystal composition, liquid crystal device, display apparatus and display method An optically active compound represented by the following formula (I): ##STR1## wherein R1 denotes a linear or branched alkyl group having 1-18 carbon atoms optionally including one or non-neighboring two or more methylene groups which can... | 03/16/1993 |
| 5182289 | Heterobicyclic compounds having antiinflammatory activity Heterobicyclic and heterocyclic intermediate compounds and their use in treating inflammation, hyperproliferative skin conditions such as psoriasis and allergy are disclosed.... | 01/26/1993 |
