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Class 548/152 - Bicyclo ring system having the thiazole ring as one of the cyclos


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the polycyclo ring system consists of
No. of patents: 251
Last issue date: 05/10/2011


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NumberTitleIssue Date
7939669Metallic compound and organic electroluminescence device comprising the same
The present invention relates to a light emitting transition metal compound of Chemical Formula 1 and an organic electroluminescence device including the compound. In the Chemical Formula 1, M is selected from Ir, Pt, Rh, Re, and Os, m is 2 or 3, n is 0 or 1,...
05/10/2011
7847101Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
Pharmaceutical pyrazolybenzothiazole compositions of formula (1) are provided. The compositions may be pharmaceutically acceptable salts. R1, R2 and R3 at each occurrence are independently selected from amino, aminosulfinyl, aminosul...
12/07/2010
78165364-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles and methods for making same
Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzox...
10/19/2010
7767823Process for the purification of a salt of clavulanic acid
A process in which a salt of clavulanic acid, typically an amine salt or an alkali metal salt is exposed to conditions, particularly a pH of less than 6.0, which reduces the quantity of contaminating impurities. The process may be a washing process, a recrystallisat...
08/03/2010
7419993Triazolo-epothilones
The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ...
09/02/2008
7414056Pyrazole-amide compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6
08/19/2008
7390810Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6
06/24/2008
7384625Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the f...
06/10/2008
7384965Fused heterocyclic derivatives as PPAR modulators
The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U ia an aliphatic linker; (c) Y is selected from the gr...
06/10/2008
73849662-arylbenzothiazole derivatives
A compound of general structure I, wherein the compound is optionally in the form of an N-oxide or S-oxide or prodrug form and/or pharmaceutically acceptable salt thereof wherein: each of R1 to R
06/10/2008
7378433N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-...
05/27/2008
7320995Benzimidazoles and benzothiazoles as inhibitors of map kinase
The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of m...
01/22/2008
7319151Thermally cross-linkable two-photon chromophores
Provided are new two-photon absorbing chromophores of the formula: wherein R is an alkyl group having 1 to 20 carbon atoms and Q is OH, OMe, propargyloxy-(O—CH2—C≡CH), methylpropargyloxy-(O—CH
01/15/2008
7309715Compound
A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl...
12/18/2007
7304058Carbamic acid esters of benzothiazoles
The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases relat...
12/04/2007
7300928Benzimidazolidinone derivatives as muscarinic agents
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the s...
11/27/2007
7282512Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, inclu...
10/16/2007
7276518Substituted cyclohexane-1,4-diamine compounds
Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds. ...
10/02/2007
7270800Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds....
09/18/2007
7253154Substituted thiazolopyrimidines as xanthine oxidase inhibitors
The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m...
08/07/2007
RE39744Adamantane derivatives and process for producing them
In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group...
07/24/2007
7214695Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective...
05/08/2007
7214696Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective...
05/08/2007
7208450Pesticidal (dihalopropenyl) phenylalkyl substituted benzoxazole and benzothiazole derivatives
Certain novel (dihalopropenyl)phenylalkyl substituted benzoxazole and benzothiazole derivatives have unexpected insecticidal activity. These compounds are represented by formula (I): where R through R11, inclusively. x, A, B, y, D, E and G are fully descr...
04/24/2007
7202404Fungicidal amides
Compounds of Formula I are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1–C2 alkoxy; C1–C2
04/10/2007
7196200Antibacterial compounds
Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containi...
03/27/2007
7176037Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods inclu...
02/13/2007
7157456Substituted oxazolidinones and their use in the field of blood coagulation
The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxi...
01/02/2007
7144743Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, ...
12/05/2006
7138529Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the...
11/21/2006
7132439Bis-benzimidazoles and related compounds as potassium channel modulators
The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods. ...
11/07/2006
7129259Halogenated biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet...
10/31/2006
7115640Heterocyclic modulators of nuclear receptors
Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I...
10/03/2006
7112590Thrombin inhibitors
The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof. The compounds are used as thrombin inhibitors ...
09/26/2006
7112413Heteroaryl substituted benzothiazole dioxetanes
Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: The...
09/26/2006
7094790Fused bicyclic-substituted amines as histamine-3 receptor ligands
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 recep...
08/22/2006
7091360Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof
The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors. ...
08/15/2006
7087593Benzimidazolidinone derivatives as muscarinic agents
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the s...
08/08/2006
7064216Condensation reagents and a process for their preparation
The present invention relates to new bromo- and chlorothiazolium salts of the formula (I) in which R1, R2, R3, R4, n and X− have the meaning indicat...
06/20/2006
7053088Vanilloid receptor ligands and their use in treatments
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an...
05/30/2006
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