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Class 548/148 - Polycyclo ring system having the thiazole ring as one of the cyclos


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the thiazole ring is a cyclo in a polycyclo
No. of patents: 54
Last issue date: 04/03/2012


1    
NumberTitleIssue Date
8148539Cyanine dye labelling reagents
Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring stru...
04/03/2012
8101776Organic semiconductors and their manufacture
The invention relates to a semiconductor device comprising a compound of the formula I and of the formula XXI, wherein the symbols have the meanings defined in the specification, to the novel compounds of the formula I and XXI and to the use of such a compound as an...
01/24/2012
7750163Cyanine dye labelling reagents
Disclosed are cyanine dyes that are useful for labeling and detecting biological and other materials. The dyes are of formula (I) in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6
07/06/2010
7419993Triazolo-epothilones
The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ...
09/02/2008
7407977Substituted N-acyl-2-aminothiazoles
There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea. ...
08/05/2008
7335470Compilations of nucleic acids and arrays and methods of using them
In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p...
02/26/2008
7317107Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy;...
01/08/2008
7309715Compound
A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl...
12/18/2007
7276611Process for synthesizing beta-lactamase inhibitor intermediates
There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are usefu...
10/02/2007
7270800Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds....
09/18/2007
7268135Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ...
09/11/2007
7196200Antibacterial compounds
Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containi...
03/27/2007
7192657Ethynyl containing electron transport dyes and compositions
Compounds, compositions, organic electronic devices, and methods for preparing organic electronic devices are described. The compounds of the invention contain at least two carbon-carbon triple bonds and a heteroaromatic ring having at least one —C═N— unit. Th...
03/20/2007
7172907Cyanine dye labelling reagents with -substitution
Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the...
02/06/2007
7166715Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and...
01/23/2007
7132439Bis-benzimidazoles and related compounds as potassium channel modulators
The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods. ...
11/07/2006
70912324-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic re...
08/15/2006
7041825Additive compound for curing halogenated polymers
The present invention relates to 1,3,4-thiadiazole reaction products useful as accelerators and/or curing agents for halogenated polymers in rubber vulcanization processes, and to halogenated polymer compositions containing the thiadiazole derivatives, as well as a ...
05/09/2006
7008798Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type...
03/07/2006
6977305Modified carbocyanine dyes and their conjugates
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a...
12/20/2005
6956032Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
The present invention pertains to luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type...
10/18/2005
6800380Organometallic luminescent materials and organic electroluminescent device containing same
An organometallic luminescent material comprising the compound of formula (I) of the present invention can emit pure blue light and have high thermal stability: wherein, M1 is a monovalent or tetravalen...
10/05/2004
6756497Benzoic acid derivatives and processes for the preparation thereof
Benzoic acid derivatives useful as intermediates for the preparation of drugs and agricultural chemicals, particularly compounds having herbicidal activity; and easy and economical processes for the preparation of the same. The processes are specifically those repre...
06/29/2004
6750024Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n range...
06/15/2004
6635696Curing compound and method of curing halogenated polymers
Additives including dithiocarbamyl derivatives of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) useful as curing agents and accelerators. Curable polymer compositions including at least one halogenated polymer and at least one additive including the dithiocarba...
10/21/2003
6548505Radioprotectors
Use of a compound of formula (I): ##STR1## wherein X is optionally substituted aminoalkyl, optionally substituted alkylene or an interactive group; Y and Z may be the same or different and are selected from N, O, S and C(R') wherein R' is hydrogen, option...
04/15/2003
6541618Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
The invention provides an asymmetric cyanine dye compound having the structure ##STR1## including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The in...
04/01/2003
6475730Detecting nucleic acids
The present invention relates to a method of detecting nucleic acids and particularly to a method of analyzing for the presence and/or amount of a nucleic acid....
11/05/2002
6335450Efficient cyclic-bridged cyanine dyes
This invention provides cyclic-bridged dyes, particularly cyclic-bridged cyanine dyes, of the general formula: ##STR1## In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted aromatic ring; n=1-18;...
01/01/2002
6331632Cyanine dye phosphoramidites
This invention provides dye phosphoramidites, particularly phosphoramidites of cyanine and related dyes, of the general formula: ##STR1## In this formula, each dotted line represents carbon atoms necessary to form a fused substituted or unsubstituted arom...
12/18/2001
62812384-aryl-1-oxa-9-thia-cylopenta[B]fluorenes
This invention provides compounds of Formula I having the structure ##STR1## wherein B and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon atoms; R1 is hydrogen, alkyl of 1-6 carbon atom...
08/28/2001
6274738Carboxamide derivatives having aryl and thiazole rings
The invention provides DNA primase assays suitable for identifying DN primase modulating agents, methods of modulating DNA primase activity, compounds for modulating DNA primase activity, and compositions which modulate DNA primase....
08/14/2001
6222044Process for making 2-aryl benz (ox, thi, imid) azoles and 2-aminoaryl aminobenz (ox, thi, imid) azoles
2-(aryl)-benz(ox, thi, imid)azoles are prepared by reacting an aromatic aldehyde with hydroxylamine to form an aromatic aldehyde oxime, halogenating the oxime to form an aromatic hydroxamoyl halide, and then reacting this halide with certain aromatic amin...
04/24/2001
6218359Screening method using the RZR receptor family
The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonistic activity and th...
04/17/2001
6124277Antithrombotic agents
This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors....
09/26/2000
6080868Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
The invention provides an asymmetric cyanine dye compound having the structure ##STR1## including substituted forms thereof, wherein, at least one of R1 and R2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The ...
06/27/2000
6048982Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attac...
04/11/2000
6043373Heterocycle-fused thiazole derivatives
A thiazole compound represented by general formula (I), wherein R is hydrogen atom, a hydroxy group, a straight or branched C1 -C6 lower alkyl group, a C1 -C4 lower alkoxy group, phenyl group, a phenyl group hav...
03/28/2000
5968933DNA-targeted alkylating agents
The invention relates to novel bis-benzimidazole compounds which have the ability to bind to the minor groove of DNA and to alkylate DNA, to methods of preparing the compounds, and the use of the compounds in the treatement of neoplastic disease....
10/19/1999
5846666Electroluminescent devices
An electroluminescent device comprised of a metal thioxinoid of the formula ##STR1## wherein M represents a metal; each n is a number of from 1 to 3; N is nitrogen, S is sulfur, and Z represents an aromatic moiety....
12/08/1998
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