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| Number | Title | Issue Date |
| 8034954 | Calcium channel antagonists The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists. ... | 10/11/2011 |
| 8026369 | Composition containing thiazole rings, organic semiconductor polymer containing the composition, organic active layer containing the organic semiconductor polymer, organic thin film transistor containing the organic active layer, electronic device containing the organic thin film transistor and method of preparing the same Disclosed herein is a composition containing hetero arylene or arylene showing a p-type semiconductor property in addition to thiophene showing a p-type semiconductor property and thiazole rings showing a n-type semiconductor property at a polymer main chain, an org... | 09/27/2011 |
| 8003801 | Chemical synthesis of a highly potent epothilone A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone. ... | 08/23/2011 |
| 7829722 | Ionic liquids The present invention relates to compositions of matter that are ionic liquids, the compositions comprising any of eleven cations combined with any of three fluorinated sulfonated anions. Compositions of the invention should be useful as solvents and, perhaps, as ca... | 11/09/2010 |
| 7777047 | Indole compound The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing ... | 08/17/2010 |
| 7767822 | Water-soluble tetrazolium salts Thiazolyl tetrazolium salts with increased solubility in aqueous solutions have alkylammonium alkoxy substituents, preferably trimethyl ammonium propoxy groups substituents, on phenyl rings attached to the tetrazolium ring. Thiazolyl tetrazolium salts with increased... | 08/03/2010 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7438894 | Dyes for organ function monitoring Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 10/21/2008 |
| 7431741 | Brightening colorant with indolythiazolium dyes The present invention has for an object agents for the simultaneous brightening and dyeing of keratin fibers—particularly hair—characterized in that they contain a) at least one oxidant and (b) at least one indolylthiazoliumazo dye of formula (I) and that, (c) t... | 10/07/2008 |
| 7429274 | Agent and method for the oxidative coloring of keratin fibers The object of the present invention is a ready-to-use agent for coloring keratin fibers containing (i) at least one heterocyclic hydrazone derivative of formula (I), (ii) at least one CH-active compound of formulas (II) to (IX) and (iii) at least one oxidant, a mult... | 09/30/2008 |
| 7429278 | N-alkyleheteroaryl secondary para-phenylenediamine and composition comprising such a para-phenylenediamine The present disclosure is directed to a family of N-alkylheteroaryl secondary para-phenylenediamines, to their preparation, and to a cosmetic composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprising, in a suitable dyeing ... | 09/30/2008 |
| 7427635 | Substituted hydantoins The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, ... | 09/23/2008 |
| 7425221 | Composition comprising at least one substituted derivative of carbocyanine, method for treating keratin fibers using it, device and use The invention relates to a composition comprising, in a cosmetically acceptable medium, at least one particular direct dye. The invention further relates to a method for treating keratin fibers, in particular human keratin fibers, using the abovementioned com... | 09/16/2008 |
| 7425555 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... | 09/16/2008 |
| 7419993 | Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ... | 09/02/2008 |
| 7417030 | Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, athero... | 08/26/2008 |
| 7414067 | Ophthalmic compositions for treating ocular hypertension This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co... | 08/19/2008 |
| 7408069 | Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives A method for preparing a compound of the structure I, ... | 08/05/2008 |
| 7407977 | Substituted N-acyl-2-aminothiazoles There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea. ... | 08/05/2008 |
| 7396943 | Opioid receptor antagonists A compound of the formula I: (I) wherein the variables are as described herein, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixture thereof, formulations and methods of use thereof are disclosed. | 07/08/2008 |
| 7393865 | Sleep inducing compounds and methods relating thereto Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L | 07/01/2008 |
| 7393366 | Agents for coloring keratin fibers The present invention relates to agents for coloring keratin fibers which comprise at least one zwitterionic azo dye of the general formula (I) where R1 is an alkylsulfonate radical of the formula (II), ... | 07/01/2008 |
| 7384968 | Thiazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula I have activity inhibi... | 06/10/2008 |
| 7378421 | Chromenone derivatives Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for... | 05/27/2008 |
| 7371767 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 Pyrrole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, ... | 05/13/2008 |
| 7371777 | Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ... | 05/13/2008 |
| 7361755 | Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with a sterically hindered nitroxyl radical. ... | 04/22/2008 |
| 7348346 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, sy... | 03/25/2008 |
| 7345067 | Aniline derivatives, their manufacture and use as pharmaceutical agents This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; R1 is hydrogen or C1-7... | 03/18/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7335775 | Effector conjugates, process for their production and their pharmaceutical use Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjuga... | 02/26/2008 |
| 7335776 | Remedies for depression containing EP1 antagonist as the active ingredient A pharmaceutical composition for the treatment and/or prevention of depression comprising a compound having an antagonistic activity for EP1 receptor which a prostaglandin E2 receptor subtype. EP1 antagonist is useful for the ... | 02/26/2008 |
| 7329288 | N-heteroaryl secondary para-phenylenediamine, a dye composition comprising such a para-phenylenediamine, a process for preparing this composition and use thereof The present disclosure relates to a novel family of N-heteroaryl secondary para-phenylenediamines, to their preparation, to their use for dyeing the hair and to a dye composition for dyeing keratin fibers, for example, human keratin fibers such as the hair, comprisi... | 02/12/2008 |
| 7326259 | Use of polycationic compounds in the dyeing of keratinous fibres A subject-matter of the present patent application is the use, as direct dye in dyeing compositions for keratinous fibres, in particular human keratinous fibres, such as the hair, or for the manufacture of such compositions, of a specific polycationic compound. ... | 02/05/2008 |
| 7326254 | Means and method for the simultaneous bleaching and dyeing of keratin fibres The present patent application has for an object an agent for the simultaneous brightening and coloring of keratin fibers based on a coupler-developer combination that has a basic pH and contains as developer at least one heterocyclic hydrazone derivative of formula... | 02/05/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7317007 | Benzothiazole derivatives with activity as adenosine receptor ligands The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor. ... | 01/08/2008 |
| 7316851 | Electroluminescent material, electroluminescent element and color conversion filter An electroluminescent element is disclosed, comprising an electroluminescent material and a fluorescent substance emitting light having an emission maximum at the wavelength different from that of light emitted from the electroluminescent material upon absorption of... | 01/08/2008 |
| 7309715 | Compound A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl... | 12/18/2007 |
