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| Number | Title | Issue Date |
| 7906652 | Heterocycle-substituted 3-alkyl azetidine derivatives Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are... | 03/15/2011 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7390804 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity aga... | 06/24/2008 |
| 7217832 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 05/15/2007 |
| 7211668 | PNA monomer and precursor This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: | 05/01/2007 |
| 7208509 | Non-nucleoside reverse transcriptase inhibitors This invention relates to novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human ... | 04/24/2007 |
| 7205321 | Peroxisome proliferator activated receptor alpha agonists The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected fr... | 04/17/2007 |
| 7196199 | Phenoxypropylamine compounds The present invention relates to a phenoxypropylamine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt... | 03/27/2007 |
| 7166624 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 01/23/2007 |
| 7144901 | Oxadiazole derivatives and drugs containing these derivatives as the active ingredient An oxadiazole derivative of formula (I) and a non-toxic salt thereof, wherein R is hydrogen, alkyl, CycA, etc.; AA1 is a single bond, amino acid residue, etc.; AA2 is a single bond, amino ac... | 12/05/2006 |
| 7115639 | Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in... | 10/03/2006 |
| 6919331 | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatm... | 07/19/2005 |
| 6908937 | Heterocyclic fluoroalkenyl thioethers (II) The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which X represents hydrogen, halogen or alkyl, m represents integers from 3 to 10, | 06/21/2005 |
| 6900233 | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof A substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-one, compound of formula 1, wherein R1, R2, R3, R4 and R5 are as defined herein, pharmaceutical composition ... | 05/31/2005 |
| 6852716 | Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmac... | 02/08/2005 |
| 6838415 | Substituted benzoylisoxazoles and the use thereof as herbicides The invention relates to novel substituted benzoylisoxazoles of the general formula (I), in which n represents the number 0, 1, 2 or 3, A represents a single bond or ... | 01/04/2005 |
| 6797720 | 1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient A 1,3,4-oxadiazoline derivative of formula (I) wherein W is oxygen, sulfer; R is hydrogen, alkyl, CycA, etc.; AA1 is a single bond, amino acid residue, etc.; AA2 is a single bond, amino acid residue... | 09/28/2004 |
| 6696475 | Substituted phenyl derivatives, their preparation and use The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.... | 02/24/2004 |
| 6670481 | Oxiranecarboxylic acids for the treatment of diabetes The invention relates to novel arylalkyl- or aryloxyalkyl-substituted oxiranecarboxylic acids of the general formula I: ##STR1## in which Ar, R3, Y and n are as defined in the description, and also to medicaments comprising them and to their us... | 12/30/2003 |
| 6596742 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use in medicaments Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones of the formula 1 ##STR1## in any optically isomeric form, and their physiologically acceptable salts, where R1 is C1 -C6 -alkyl, C3 -C9 -cycloalkyl, ... | 07/22/2003 |
| 6545030 | 1-heterocycle substituted diarylamines 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.... | 04/08/2003 |
| 6472414 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters... | 10/29/2002 |
| 6413996 | Diaminocyclobutene-3,4-dione derivatives, their preparation and use The invention relates to compounds having the formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), X represents a group having the structural formula (II), and Y represents O or S. The compounds of the invention can be used a chl... | 07/02/2002 |
| 6388070 | Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), ##STR1## wherein, R1 represents H, trityl, CH3, or CRa Rb COOR3, in which Ra ... | 05/14/2002 |
| 6384215 | Preparation of new intermediates and their use in manufacturing of cephalosporin compounds The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said thioester derivatives can be prepared by reacting 4-halogeno-... | 05/07/2002 |
| 6369088 | Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, their preparation and their use as pharmaceuticals Substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones of the formula 1 are described, ##STR1## in which R1 is substituted C1 -C6 -alkyl and C3 -C9 -cycloalkyl, R2, R3, R4 | 04/09/2002 |
| 6342245 | Compositions of lipid lowering agents The present invention is concerned with novel pharmaceutical compositions of lipid lowering agents which can be administered to a mammal suffering from hyperlipidemia, obesitas or atherosclerosis, whereby a single such dosage form can be administered once... | 01/29/2002 |
| 6306852 | Indole derivatives useful as endothelin receptor antagonists ##STR1## Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R1 and R2 are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl, optionally substituted by C... | 10/23/2001 |
| 6297241 | Carbamate derivatives of diaryl 1,3,4-oxadiazolone The present invention provides novel carbamate oxadiazolone derivatives having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the tre... | 10/02/2001 |
| 6297261 | Substituted phenyl derivatives, their preparation and use A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##... | 10/02/2001 |
| 6288236 | Benzimidazole compounds containing a benzoxazole or benzothiazole ring, and compositions and methods of use containing the same Benzimidazole compounds represented by the formula set out below and analogs thereof, wherein Y represents a single bond or sulfur atom; Z represents oxygen atom, sulfur atom, or N--R4 ; R1 and R2 independently represent h... | 09/11/2001 |
| 6271254 | Pharmaceutical compositions containing R--lipoic acid or S--lipoic acid as active ingredient Pharmaceutical compositions and processes for their preparation containing R--lipoic acid or S--lipoic acid or pharmaceutically acceptable salts thereof. The pharmaceutical compositions have a cytoprotective activity and are suitable for com... | 08/07/2001 |
| 6258751 | Substituted triazoles imidazoles and pyrazoles as herbicides The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of herbicidal compositions containing these compounds. In parti... | 07/10/2001 |
| 6255327 | Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) ##STR1## wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for prep... | 07/03/2001 |
| 6251829 | Herbicidal benzoyloxy carboxylates and carboxamides This invention relates to herbicidal alpha-(2,4,5-trisubstituted)- and alpha-(2,5-disubstituted)-benzoyloxy-alpha-beta-, and/or beta-gamma-unsaturated-carboxylates and their derivatives, to compositions which contain these compounds, and to methods of use... | 06/26/2001 |
| 6248757 | 3-(Pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives and their use as 5-HT4 ligands Compounds corresponding to the general formula (I) ##STR1## in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group, or alternatively OR1 and X1 | 06/19/2001 |
| 6197770 | Alkenyl- and alkynl-containing metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): #... | 03/06/2001 |
| 6184383 | Method of producing acetals There is disclosed a method of producing acetals, which comprises reacting a compound of formula (I), at least one compound selected from a group consisting of a compound of formula (II), paraformaldehyde, and trioxane; and a compound of formula (III), to... | 02/06/2001 |
| 6162817 | Carbamate derivatives of diaryl 1,3,4-oxadiazolone The present invention provides novel carbamate oxadiazolone derivatives having the general formula ##STR1## wherein R1 and R2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are usefu... | 12/19/2000 |
| 6100252 | Heterocyclic compounds and their use as angiotensin antagonists | 08/08/2000 |
