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| Number | Title | Issue Date |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7371746 | 1,2,4-Thiadiazole compounds and pests controlling composition containing the same The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R2?, C4-C7 straight alkenylene o... | 05/13/2008 |
| 7361675 | 1,2,4-thiadiazole compounds and use thereof 1,2,4-Thiadiazole compounds represented by the formula (1) have excellent control activities against harmful arthropods: wherein R1 represents C3-C7 alkynyl group optionally substituted one or more halogen atom(s... | 04/22/2008 |
| 7342031 | Thiadiazole compound and use thereof The thiadiazole compound represented by the formula (A): wherein R1 represents a C1-C7 alkyl group, a C3-C7 alkenyl group, a C3-C7 alkynyl group and the like; R2 represents a C1-C4 alkyl group substituted with a ... | 03/11/2008 |
| 7273879 | Thiadiazole compounds and use thereof A thiadiazole compound of the formula (A): wherein R1 represents methyl, C3-C7 alkenyl, C2-C7 alkoxyalkyl, C2-C7 alkylthioalkyl, C4-C7 alkoxyalkoxyalkyl, C4-C7 alkylthioalkoxyalkyl, phenyl C1-C2 alk... | 09/25/2007 |
| 7173125 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 02/06/2007 |
| 7141672 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ... | 11/28/2006 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 7015329 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 03/21/2006 |
| 6861106 | Dichroic dye, composition thereof, and liquid crystal composition and liquid crystal display element containing the same Dichroic dyes, dichroic dye compositions, and liquid crystal composition and liquid crystal display element containing the dichroic dyes. The dichroic dye has increased solubility and stability. ... | 03/01/2005 |
| 6699896 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds having the structure ##STR1## wherein A is OR5, or ##STR2## R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, ##STR3## R2 is H, alkyl, or aryl; R3 | 03/02/2004 |
| 6500944 | Sulfurizing reagent: 3-aryl-1,2,4-dithiazoline-5-ones The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleotide linkages of oligonucleotides. The invention provides a ... | 12/31/2002 |
| 6492421 | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g.... | 12/10/2002 |
| 6468977 | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by i... | 10/22/2002 |
| 6380386 | Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality of processes for their preparation.... | 04/30/2002 |
| 6323315 | Dolastatin peptides The present invention provides compounds of the formula ##STR1## where R1 -R5 are each, independently, a hydrogen atom or a normal or branched C1 -C6 -alkyl group; A is a methionyl, phenylalanyl or phenylglycyl ... | 11/27/2001 |
| 6277994 | Color-developing agent, silver halide photographic light-sensitive material and image-forming method There is disclosed a novel color-developing agent of a 1,2,4-thiadiazol-5-yl hydrazine type. There is also disclosed a silver halide photographic light-sensitive material which gives sufficient color formation by development and forms an image excellent i... | 08/21/2001 |
| 6162791 | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by i... | 12/19/2000 |
| 6150374 | Substituted cycloalkenes, process of preparing them and method of using them as pesticides The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for their preparation.... | 11/21/2000 |
| 6114537 | Process for scavenging thiols Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The... | 09/05/2000 |
| 5981556 | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5977149 | Dihydrotriazole compounds and their use for controlling fungal plant diseases Cyclic amides of Formula (I) which are useful as fungicides wherein: A is O; S; N; NR5 ;or CR14--, G is C or N; W is O or S; X is OR1, S(O)m R1 or halogen; R1, R2, and R5 a... | 11/02/1999 |
| 5972978 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their... | 10/26/1999 |
| 5958957 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their... | 09/28/1999 |
| 5852168 | Sulfurization of phosphorus-containing compounds The present invention provides a method for sulfurizing a phosphorus-containing compound, such as a trivalent phosphorus compound, using a disulfide-containing five-membered heterocycle.... | 12/22/1998 |
| 5827800 | Alkyl sulphinyl and alkyl sulphonyl-1,2,4-thiadiazolyloxy acetamides and their use as herbicides The invention relates to novel alkyl sulphinyl and alkyl sulphonyl-1,2,4-thiadiazolyloxy acetamides of formula (I) ##STR1## in which n is the numbers 1 or 2, R1 is hydrogen or possibly substituted alkyl, alkenyl, alkinyl or aralkyl, R... | 10/27/1998 |
| 5763617 | Cephalosporins A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an integral salt or their salts with organic or mineral acids wherei... | 06/09/1998 |
| 5683859 | Photographic developing composition containing a sludge inhibiting agent and use thereof in the high contrast development of nucleated photographic elements An improved photographic developing composition, for use in development of a black-and-white silver halide photographic element, is comprised of at least one developing agent and, in an amount sufficient to inhibit sludge deposition, mercapto thiadiazole ... | 11/04/1997 |
| 5622922 | Method of solubilizing a benzotriazole with a thiadiazole A homogenous product is formed by heating at a temperature in the range of from 50° to 150° C. a mixture of a benzotriazole and a 2,5-dihydrocarbyldithio-1,3,4-thiadiazole.... | 04/22/1997 |
| 5612483 | Process for the preparation of nitro-substituted arylamines Nitro-substituted aromatics can be directly aminated with amines in the presence of simple bases and oxygen.... | 03/18/1997 |
| 5569655 | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 10/29/1996 |
| 5554633 | Substituted amines as tachykinin receptor antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H or C1-6 alkyl; R1 | 09/10/1996 |
| 5550138 | Condensed thiadiazole derivative, method of its production, and use thereof (1) a compound represented by the following formula (I): ##STR1## wherein R represents a hydrocarbon group or heterocyclic group which may be substituted; the ring A represents a pyridine ring having a substituent or a thiazole ring which may be subs... | 08/27/1996 |
| 5532256 | New azolidinediones and thiadiazolidinediones as antihyperglycemic agents This invention relates to novel compounds which have demonstrated oral antihyperglycemic activity in diabetic ob/ob and db/db mice, animal models on non-insulin dependent diabetes mellitus (NIDDM ot Type II diabetes). These compounds have the formula: ... | 07/02/1996 |
| 5523312 | Antipicornaviral agents Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1## wherein Het1 is chosen from the group consistin... | 06/04/1996 |
| 5403930 | Substituted salicylic acids A compound of the formula Het--NR--SO2 --Ph2 --A--Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benze... | 04/04/1995 |
| 5391720 | Imidazole dyes formed by reaction of imidazoles with diazonium salts Disclosed is an imidazole azo dye of formula (I), which is useful for image formation and as a filter dye, which has a sharp absorption wave and which is fast to light, heat, air, moisture and chemicals. Also disclosed is a thermal transfer dye-donating m... | 02/21/1995 |
| 5336420 | Antioxidants for functional fluids An aromatic functional fluid, specifically a monoalkylated tetradecyl diphenyl oxide synthetic lubricant, contains a polymer-supported reaction product of an organic quaternary ammonium salt, derived from a mercapto-heterocycle and a quaternary ammonium s... | 08/09/1994 |
| 5326776 | Angiotensin II receptor antagonists Compounds are disclosed having the formula: ##STR1## wherein the substituents are defined herein. The compounds of the invention are angiotensin II receptor antagonists.... | 07/05/1994 |
| 5302718 | Compounds containing an amino salicylic acid moiety linked to a sulphapyridine moiety via stable bridge A compound of the formula Het--NR--SO2 --Ph2 --A--Ph1 (COOH)(OH) and tautomeric form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are ben... | 04/12/1994 |
