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| Number | Title | Issue Date |
| 8053578 | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes The present invention provides novel alpha-fluoroalkyl dihydrotetrabenazine compounds I wherein R1 is a C1-C10 fluorinated aliphatic radical; R2 is hydrogen or a C1-C | 11/08/2011 |
| 8039627 | Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol compounds and methods relating thereto Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol compounds are disclosed that are inhibitors of the vesicular monoamine transporter 2 (VMAT2). The compounds of this invention have the structure: | 10/18/2011 |
| 8013161 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes The present invention provides novel fluoroalkyl tetrabenazine carbinol compounds having structure I wherein R1 is a C1-C10 fluorinated aliphatic radical; R2 is a C1-C | 09/06/2011 |
| 7919622 | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes The present invention provides novel fluorophilic compounds having structure VII wherein R1 is a C1-C20 aliphatic, a C2-C20 cycloaliphatic, or a C2-C20 ... | 04/05/2011 |
| 7910738 | Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes The present invention provides novel fluorophilic compounds having structure VII wherein Q is a carbonyl group, a protected carbonyl group, a hydroxy methine group, or a protected hydroxy methine group; R1 is a C... | 03/22/2011 |
| 7902364 | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes The present invention provides novel alpha-fluoroalkyl compounds having structure I and the corresponding dihydrotetrabenazine compounds IV wherein R1 is a C1-C10 fluorinated aliphatic radic... | 03/08/2011 |
| 7897768 | Method for making tetrabenazine compounds A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P1 ... | 03/01/2011 |
| 7897769 | Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes The present invention provides novel fluorophilic compounds having structure VI wherein R1 is a C2-C20 aliphatic, a C3-C20 cycloaliphatic, or a C3-C20 | 03/01/2011 |
| 7897770 | Fluorinated dihydrotetrabenazine ether imaging agents and probes The present invention provides novel fluorinated ether compounds having structure I wherein R1 is a C2-C10 fluorinated aliphatic radical; R2 is a C1-C10 alip... | 03/01/2011 |
| 7229989 | Blue 3H-naphtho[2,1-b]pyran compounds and use thereof in photochromic articles Photochromic 3H-naphtho[2,1-b]pyran compounds corresponding to formula I in which the groups R1 to R7 and B′ have defined meanings and the use of such photochromic compounds in synthetic r... | 06/12/2007 |
| 7202002 | Hydrazone-based charge transport materials Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 04/10/2007 |
| 7179574 | Hydrazone-based charge transport materials Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 02/20/2007 |
| 7166744 | Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds The present invention relates to a novel retinoid derivative compound represented by the formula I: wherein X, R1, R2 and R3 are as defined herein or pharmaceutically acceptalbe s... | 01/23/2007 |
| 7164023 | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate The invention relates to crystalline S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as... | 01/16/2007 |
| 7132209 | Organophotoreceptor with charge transport material having three arylamino groups Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 11/07/2006 |
| 7122555 | Pyrido [2,1-a] isoquinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as indicated in the description, or a pharmaceutically acceptable salt thereof. Th... | 10/17/2006 |
| 7098219 | Inhibitors of cellular efflux pumps of microbes Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.... | 08/29/2006 |
| 6962925 | Benzo(C)quinolizine derivatives and their use as 5α-reductases inhibitors A fully and partially reduced benzo(c)quinolizine compound of formula (1): ... | 11/08/2005 |
| 6897222 | Pyrido[2,1-a]isoquinoline derivatives The present invention provides compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically acc... | 05/24/2005 |
| 6864028 | Di-hydrazone based charge transport compounds Improved organophotoreceptors have: (a) a charge transport compound having the formula where R1 and R2 are, independently, an (N,N-disubstituted) arylami... | 03/08/2005 |
| 6750224 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(â... | 06/15/2004 |
| 6723850 | Process for the synthesis of (1-H)-benzo[c]quinolizin-3-ones derivatives The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The comp... | 04/20/2004 |
| 6673930 | Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno [3,4-F] quinolines and derivatives thereof The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]q uinolines.... | 01/06/2004 |
| 6649089 | Red organic electroluminescent materials A red fluorescent material comprising a compound of Formula I: ##STR1## wherein R1, R2, R3, R4, R5, and R6 each independently represents a linear or branched aliphatic group having from 1 t... | 11/18/2003 |
| 6630482 | CFTR channel activator compounds and pharmaceutical compositions containing same CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic fibrosis, are discl... | 10/07/2003 |
| 6555549 | Benzo[C] quinolizine derivatives, their preparation and use as 5-reductases inhibitors The present invention refers to benzo[c]quinolizine derivatives of general formula (I) ##STR1## their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.... | 04/29/2003 |
| 6552034 | Benzo[c]quinolizine derivatives, their preparation and use as 5-reductases inhibitors The present invention refers to benzo[c]quinolizine derivatives of general formula (I) ##STR1## their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.... | 04/22/2003 |
| 6518430 | Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]q uinolines and derivatives thereof The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]q uinolines.... | 02/11/2003 |
| 6514912 | Use of benzo[C]quinolizine derivatives as plant growth regulators Disclosed are compositions of benzo(c)quinolizine derivatives and methods for promoting plant and seed growth. The compounds are benzo[c]quinolizine derivatives which exert an inhibiting effect on the 5-alpha-reductase enzymes. The compounds selectively a... | 02/04/2003 |
| 6303622 | Benzo[c]quinolizine derivatives, their preparation and use as 5-reductases inhibitors The present invention refers to benzo[c]quinolizine derivatives of general formula (I) ##STR1## their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.... | 10/16/2001 |
| 6242450 | 5-HT1F antagonists This invention provides 5-HT1f antagonists of Formula I: ##STR1## where AR1, AR2, R, and R' are as defined in the specification.... | 06/05/2001 |
| 6133283 | Mono- or polyenic carboxylic acid derivatives To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologic... | 10/17/2000 |
| 6013653 | Processes for producing pyridoindole derivatives A process for producing pyridiondole derivatives represented by general formula (III) or their salts (wherein R1 represents hydrogen, lower alkyl or lower alkenyl; R2 represents hydrogen, lower alkyl or halogeno; and R3 re... | 01/11/2000 |
| 5990121 | Use of 1,2-bridged 1,4-dihydropyridines as medicaments The present invention relates to the new use of 1,2-bridged 1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R1 to R4 and a have the meaning indicated in the description, proc... | 11/23/1999 |
| 5811552 | Cyclobutenedione derivative, process for preparing the same, and nonlinear optical element A novel cyclobutenedione derivative prepared in accordance with the following reaction formula, a process for the preparation thereof, and a nonlinear optical element comprising such a derivative are provided: ##STR1## wherein R1 and R | 09/22/1998 |
| 5747503 | Selective inhibitors of biogenic amine transporters The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are i... | 05/05/1998 |
| 5723633 | Pyran derivative, photosensitive resin composition, and hologram recording medium using it A pyran derivative has a structure of R2 R3 C.dbd.(C5 H2 R1 O)--(CH.dbd.CH)n --C6 H2 R6 R7 --NR4 R5 wherein n is 3 or 4; R1 | 03/03/1998 |
| 5676884 | Nonlinear optical materials containing polar disulfone-functionalized molecules Nonlinear optical (NLO) compositions are disclosed which contain polar disulfone-functionalized molecules (PDFMs) incorporated in a polymeric material. when aligned noncentrosymmetrically in the polymeric material, the PDFMs generate a second-order NLO re... | 10/14/1997 |
| 5578728 | Process for the preparation of a benzo(a)quinolizione derivative The invention is concerned with a process for the preparation of a benzo[a]quinolizinone derivative of the formula ##STR1## by reacting a compound of the formula ##STR2## wherein X is halogen and Ph is phenyl, with carbon monoxide in the pr... | 11/26/1996 |
| 5561233 | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative The invention is concerned with a process for the preparation of a benzo[a]quinolizinone derivative of the formula ##STR1## by reacting a compound of the formula ##STR2## wherein X is halogen and Ph is phenyl, with carbon monoxide in the pr... | 10/01/1996 |
