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| Number | Title | Issue Date |
| 8168791 | Aminomethyl azaadamantane derivatives and methods of use thereof The invention relates to compounds that are substituted aminomethyl azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. ... | 05/01/2012 |
| 8163914 | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof The invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions. ... | 04/24/2012 |
| 8163915 | 4-substituted azaadamantane derivatives and methods of use thereof The invention relates to compounds that are 4-substituted azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. ... | 04/24/2012 |
| 7342028 | Medical use for tachykinin antagonists The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharm... | 03/11/2008 |
| 7334670 | Torque vectoring differential for controlling vehicle stability A magnetorheological (MR) fluid coupling for vectoring torque with respect to a shaft capable of rotary motion is disclosed. The coupling includes a stator, a rotor having a rotational degree of freedom with respect to the stator and configured for physical communic... | 02/26/2008 |
| 7320849 | Organophotoreceptor with a charge transport material having two epoxidated-hydrazone groups Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 01/22/2008 |
| 7270932 | Imaging composition and method Imaging compositions and methods of using the compositions are disclosed. The imaging compositions are sensitive to low levels of energy such that upon application of the low levels of energy the compositions change color or shade. The compositions may be used in me... | 09/18/2007 |
| 7247642 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment The present invention relates to optically pure S-(β)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(β... | 07/24/2007 |
| 7223519 | Imaging compositions and methods Imaging compositions and methods of using the compositions are disclosed. The imaging compositions are sensitive to low levels of energy such that upon application of the low levels of energy the compositions change color or shade. The compositions may be applied to... | 05/29/2007 |
| 7217465 | Pyran derivative A light-emitting compound that can be easily applied to vacuum vapor deposition and exhibit long wavelength light is disclosed. Further, a light-emitting element without inferior luminescence properties due to the carbonization of a light-emitting compound during va... | 05/15/2007 |
| 7164023 | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate The invention relates to crystalline S-(β)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as... | 01/16/2007 |
| 7144913 | Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Dihydropyrroloindoles and tetrahydropyridoindoles are prostaglandin receptor antagonists useful for the treatment of prostaglandin-mediated diseases such as allergic rhinitis, nasal congestion and asthma. ... | 12/05/2006 |
| 7144676 | Imaging compositions and methods Imaging compositions and methods of using the compositions are disclosed. The imaging compositions are sensitive to low levels of energy such that upon application of the low levels of energy the compositions change color or shade. The compositions may be applied to... | 12/05/2006 |
| 7135480 | Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-Ξ±]quinolines and analogs thereof, represented by the general Formula I: wherein R1βR8, L, Q, dash line and A... | 11/14/2006 |
| 7132541 | Crystalline fluoroquinolone arginine salt form The invention relates to the new arginine salt forms of RS-(Β±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(β)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]qui... | 11/07/2006 |
| 7122555 | Pyrido [2,1-a] isoquinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as indicated in the description, or a pharmaceutically acceptable salt thereof. Th... | 10/17/2006 |
| 7098219 | Inhibitors of cellular efflux pumps of microbes Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.... | 08/29/2006 |
| 7091352 | Compounds substituted with bicyclic amino groups Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R1 is a sub... | 08/15/2006 |
| 7081531 | Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists Compounds having the formula (I), Arβ(F)-(E)-(CR3R4)β(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridg... | 07/25/2006 |
| 7067261 | Methods and compositions for treatment of central nervous system disorders The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). ... | 06/27/2006 |
| 7029606 | Hyperpolarizable organic chromophores A dihydrofuran-containing nonlinear optical chromophore having a Ο-electron donor group conjugated to the dihydrofuran group through a Ο-electron conjugated bridge group. The nonlinear optical chromophore is a hyperpolarizable chromophore that can be used as an el... | 04/18/2006 |
| 7022729 | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of tr... | 04/04/2006 |
| 6964833 | Linked dihydrazone-based charge transport compounds Improved organophotoreceptors comprise: (a) a charge transport compound having the formula where n is an integer from 0 to 1; X is an (N,N-disubstituted)aryla... | 11/15/2005 |
| 6964966 | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr... | 11/15/2005 |
| 6930114 | Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer. ... | 08/16/2005 |
| 6887868 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value... | 05/03/2005 |
| 6881842 | Process for producing tricyclic fused heterocyclic derivative A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the followi... | 04/19/2005 |
| 6878713 | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr... | 04/12/2005 |
| 6867198 | Agents and methods for the treatment of proliferative diseases The present invention provides selective kinase inhibitors of formula (I) ... | 03/15/2005 |
| 6858613 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to trea... | 02/22/2005 |
| 6844089 | Organic red electro-luminescent device and dopant The invention relates to an electroluminescent device, in which the luminescent layer contains a luminescent compound and a compound of the general formula I as doping agent, wherein B is an unsaturated carbocyclic or heterocyclic 4-8-link ring, which can also conta... | 01/18/2005 |
| 6833202 | Electroluminescent devices Organic electroluminescence devices are described, each of which comprises an anode, a cathode, a luminescent layer, at least one hole-transporting layer disposed between the anode and the luminescent layer, at least one electron-transporting layer disposed between ... | 12/21/2004 |
| 6753333 | Chiral fluoroquinolone arginine salt forms The invention relates to the new arginine salt forms of S-(β)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those argini... | 06/22/2004 |
| 6750224 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment The present invention relates to optically pure S-(β)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(β... | 06/15/2004 |
| 6727261 | Pyrido[2,1-A]Isoquinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically accept... | 04/27/2004 |
| 6706880 | Cocaine receptor binding ligands The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addicti... | 03/16/2004 |
| 6696462 | Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions A compound of formula 1 ##STR1## wherein: X- is an anion with a single negative charge; A and B, which are identical or different, are each --O--, --S--, --NH--, --CH2 --, --CH.dbd.CH--, or --N(C1 -C4 -alkyl)... | 02/24/2004 |
| 6683181 | Pyrroloquinolones as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 01/27/2004 |
| 6673781 | Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl... | 01/06/2004 |
| 6664267 | Crystalline fluoroquinolone arginine salt form The invention relates to the new arginine salt forms of RS-(&#b1;)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo- 1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5 ... | 12/16/2003 |
