Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 8101761 | (E)-N-{3-[1-(8-fluoro-11H-10-OXA-1-AZA-dibenzo [A,D] cyclohepten-5ylidene)-propyl]-phenyl}-methanesulfonamide as glucocorticoid receptor modulator for the treatment of rheumatoid arthritis The present invention provides Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and discloses methods for th... | 01/24/2012 |
| 8101760 | Glucocorticoid receptor modulator and methods of use The present invention provides Compound (I): Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and methods fo... | 01/24/2012 |
| 8034940 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): | 10/11/2011 |
| 8026366 | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds ... | 09/27/2011 |
| 7973163 | Fused quinoline derivative and use thereof The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom an... | 07/05/2011 |
| 7960549 | Solid forms of a chemokine receptor antagonist and methods of use thereof The citrate salt of (S)-4-(4-Chloro-phenyl)-1-{3-[7-(1-hydroxy-1-methyl-ethyl)-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-ylidene]-propyl}-3,3-dimethyl-piperidin-4-ol, which may be used in pharmaceutical applications, is disclosed. The crystalline Citrate Salt, incl... | 06/14/2011 |
| 7951949 | Macrocyclic aminopyridyl beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alz... | 05/31/2011 |
| 7943770 | Fused quinoline derivative and use thereof The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom an... | 05/17/2011 |
| 7919621 | Tricyclic inhibitors of 5-lipoxygenase Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treatin... | 04/05/2011 |
| 7868172 | 2-(hetero)-aryl substituted tetrahydroquinoline derivatives Compounds of the formula I, in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours | 01/11/2011 |
| 7812165 | 6-substituted pyridoindolone derivatives, production and therapeutic use thereof Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description;... | 10/12/2010 |
| 7714132 | Tetrahydropyridoindole derivatives The invention relates to tetrahydropyridoindole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical co... | 05/11/2010 |
| 7632948 | Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives. ... | 12/15/2009 |
| 7626025 | Beta-carboline derived guanidine alkaloids, tiruchenduramine A novel β-carboline guanidine derivative tiruchenduramine (1) and its derivatives are disclosed. These compounds have been isolated from the Indian ascidian Synoicum macroglossum. These compounds are useful in the t... | 12/01/2009 |
| 7592453 | Fused quinoline derivative and use thereof The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom an... | 09/22/2009 |
| 7589205 | 3-thia-10-aza-phenanthrene derivatives The compounds of formula I in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors. ... | 09/15/2009 |
| 7550594 | Phenanthroline compound and organic light emitting device using same A novel phenanthroline compound is provided which is represented by the general formula [I]: (wherein R1, R2, R3, R4, R5 and R6 are the same or different and... | 06/23/2009 |
| 7427460 | Hydrazone-based charge transport materials having an ethylenically unsaturated group Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the ... | 09/23/2008 |
| 7417051 | Medicaments comprising betamimetics and a novel anticholinergic A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X− is an anion with a single negative charge; and (b) a betamimetic 2, or a... | 08/26/2008 |
| 7408063 | 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y1, Y2, R1, R2, R3, and R4 have defined meanings, having farnesyl transferase... | 08/05/2008 |
| 7375226 | Bi- and tricyclic substituted phenyl methanones The present invention relates to compounds of formula IA wherein R1, R2, R3, and n are as defined in the specification, and to pharmaceutically active acid addition salts thereof. Th... | 05/20/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7329896 | Polymerizable charge transport compounds The invention relates to polymerizable charge transport compounds, their use as semiconductors or charge transport materials, in optical, electrooptical or electronic devices like for example organic field effect transistors (FET or OFET) for thin film transistor li... | 02/12/2008 |
| 7317026 | CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. More specifically, the invention is directed to derivatized, e.g., ester or carboxylic acid derivatized, doxepins, and analogs thereof, useful for the treatment of sl... | 01/08/2008 |
| 7309789 | 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, ... | 12/18/2007 |
| 7271176 | Chemokine receptor antagonists and methods of use thereof Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologicall... | 09/18/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7253282 | Hexafluoroisopropanol substituted cyclohexane derivatives The invention is concerned with novel hexafluoroisopropanol substituted cyclohexane derivatives of formula (I) wherein R1 to R4, X, m and n are as defined in the description and in the claim... | 08/07/2007 |
| 7250423 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers The present invention provides methods for synthesizing novel tetrahydroquinoline derivatives that are useful for cancer chemotherapy and anti-viral applications. The present invention provides compounds useful for cancer chemotherapy and methods for the preparation... | 07/31/2007 |
| 7244742 | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic A pharmaceutical composition comprising: (a) an anticholinergic of formula 1 wherein X− is an anion with a single negative charge; | 07/17/2007 |
| 7227023 | Quinoline 3-amino chroman derivatives Quinoline 3-amino chroman derivatives and compositions containing such compounds are disclosed. Methods for using the quinoline 3-amino chroman derivatives and compositions containing such compounds in the treatment of serotonin disorders are disclosed. Also disclos... | 06/05/2007 |
| 7186729 | Chemokine receptor antagonists and methods of use thereof Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologicall... | 03/06/2007 |
| 7169922 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 01/30/2007 |
| 7166721 | Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel 1H-imidazo[4,5-c] quinolin 4-cyano and 1H-imidazo[4,5-c] quinolin 4-carboxamide intermediates The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-ami... | 01/23/2007 |
| 7160894 | Tricyclic compound A novel compound represented by the formula (1): [R1 represents hydrogen atom, chlorine atom, or hydroxyl group; X1 . . . X2 represents—CH(R2)—CH(R3)—,... | 01/09/2007 |
| 7148232 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor b... | 12/12/2006 |
| 7067527 | Thienopyridine derivatives, their production and use The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represen... | 06/27/2006 |
| 7060830 | Synthesized γ-carbolines The present invention concerns the compounds of the formula: and the prodrug and salts thereof, wherein R may be a hydroxyl or other pendent group and Ar is an aryl. The compositions may be adapted for the treatm... | 06/13/2006 |
| 7038051 | Imidazonaphthyridines Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful... | 05/02/2006 |
| 7038052 | Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline Methods of preparing compounds of Formula I are provided. ... | 05/02/2006 |
