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| Number | Title | Issue Date |
| 8097725 | Luminescent indicator dye and optical sensor The present invention relates to a chemical compound that has applications as a luminescent indicator dye, and to an optical sensor, typically employed for determination of near-neutral pH values of aqueous samples. The optical sensor has particular application in t... | 01/17/2012 |
| 8034939 | Isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses thereof in particular as inhibitors of chaperone protein Hsp90 activities This invention relates to isoindole derivates of Formula I to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives. ... | 10/11/2011 |
| 7968716 | Caspase inhibitors and uses thereof This invention provides novel caspase inhibitors of formula I: wherein R1 is hydrogen, CHN2, R, or —CH2Y; R is an aliphatic group, an aryl group, an aralkyl group, a heterocyclyl group, or... | 06/28/2011 |
| 7915416 | Tetrahydroquinolines Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, a... | 03/29/2011 |
| 7897766 | Amino-aza-adamantane derivatives and methods of use The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding af... | 03/01/2011 |
| 7875720 | Fluorescent monomers and tagged treatment polymers containing same for use in industrial water systems Fluorescent monomers are described and claimed which are synthesized by reacting a substituted or non-substituted naphthalic anhydride with an amine and with a moiety containing a polymerizable group. Such monomers are useful for the preparation of tagged treatment ... | 01/25/2011 |
| 7875721 | Compounds for binding to ERα/β and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ERα and ERβ). These compounds may function as agonists and/or antagonists... | 01/25/2011 |
| 7855295 | Tetrahydrocarboline compounds as anticancer agents Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional ... | 12/21/2010 |
| 7803943 | Methods of using dyes in association with nucleic acid staining or detection and associated technology Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is a... | 09/28/2010 |
| 7795436 | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists The present application describes compounds, including all pharmaceutically acceptable salts, prodrugs, solvates and stereoisomers thereof, according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at... | 09/14/2010 |
| 7767814 | Substituted piperidine compounds and methods of their use Certain 4-aryl-piperidine compounds, including N-substituted 9β-substituted-5-(3-substituted-phenyl)morphans and N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines, pharmaceutical compositions, and methods of their use, inter alia, as opi... | 08/03/2010 |
| 7608715 | Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof A compound of Formula (I) wherein R1, R2, and R3 are independently at each occurrence hydrogen, a halogen, a cyano functionality, a C1-C20 aliphatic functionality, a C | 10/27/2009 |
| 7560556 | Assay methods using chemiluminescent detection of peroxidase Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus pr... | 07/14/2009 |
| 7504507 | Anti-tumour polycyclic carboxamides This invention relates to polycyclic carboxamide compounds of the formula (I) with cytotoxicity, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly I the treatment and/or prophylaxis of cellular prolif... | 03/17/2009 |
| 7408063 | 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y1, Y2, R1, R2, R3, and R4 have defined meanings, having farnesyl transferase... | 08/05/2008 |
| 7399768 | Quinoline derivatives The present invention relates to novel benzo [g] quinoline derivatives, their preparation, their use as pharmaceuticals for use in the treatment of glaucoma and myopia. ... | 07/15/2008 |
| 7307083 | Tetrahydro-acridine and dithiolane derivatives Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease ... | 12/11/2007 |
| 7291629 | Neurotrophin antagonist compositions A pharmaceutical composition comprising a compound of Formula I wherein R1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted ami... | 11/06/2007 |
| 7273885 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents.... | 09/25/2007 |
| 7271175 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing... | 09/18/2007 |
| 7247726 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 07/24/2007 |
| 7223864 | 2-hydroxyethidium, methods of preparation and uses thereof The inventors have purified the fluorescent product in the hydroethidine-based supeorxide detection assays and further identified the product as 2-hydroxyethidium. Methods for synthesizing 2-hydroxyethidium and for detecting and quantifying superoxide are provided. | 05/29/2007 |
| 7223771 | Tricyclic imidazopyridines The invention provides compounds of the formula (I), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid. ... | 05/29/2007 |
| 7196195 | Desloratadine salts, process for their synthesis and pharmaceutical compositions thereof The object of the present invention are new desloratadine salts of formula I wherein the meaning of X is an acid residue and the meaning of n is 1 or 2, and formula II wherein the meaning of X is a pK | 03/27/2007 |
| 7192967 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group according to general formula (I), wherein the residue E is a cy... | 03/20/2007 |
| 7166721 | Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel 1H-imidazo[4,5-c] quinolin 4-cyano and 1H-imidazo[4,5-c] quinolin 4-carboxamide intermediates The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-ami... | 01/23/2007 |
| 7067668 | 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture A new agricultural and horticultural fungicide having an excellent control effect is provided. 4-Quinolinol derivatives represented by the following formula: or agriculturally and horticulturally acceptabl... | 06/27/2006 |
| 7060830 | Synthesized γ-carbolines The present invention concerns the compounds of the formula: and the prodrug and salts thereof, wherein R may be a hydroxyl or other pendent group and Ar is an aryl. The compositions may be adapted for the treatm... | 06/13/2006 |
| 7037919 | Tetrahydroquinoline derivatives Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts. | 05/02/2006 |
| 7034184 | Process for producing azine compounds and oxime compounds A process comprising allowing a peroxide compound represented by following Formula (2): wherein Ra, Rb, Rc and Rd are the same or different and are each a hydrogen atom or a h... | 04/25/2006 |
| 7030133 | Inhibitors of formation of advanced glycation endproducts (AGEs) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood an... | 04/18/2006 |
| 7022855 | Halogen-substituted quinoline derivatives and ectoparasite control agent An objective of the present invention is to provide an ectoparasite control agent for homothermic animals, which has high control effect and is safe. The compounds according to the present invention are compounds represented by formula (I) and salts thereof: | 04/04/2006 |
| 7019141 | Quinolones with anti-HIV activity The present invention relates to inhibition of viruses, e.g., HIV using quinolones and compounds related to quinolones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a ce... | 03/28/2006 |
| 7018840 | Fluorescent metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescent metal sensors for detecting metal ions, and methods of making and using the same. ... | 03/28/2006 |
| 6953791 | Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which inc... | 10/11/2005 |
| 6930104 | Heterocyclic derivatives The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present inventio... | 08/16/2005 |
| 6900322 | Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate produ... | 05/31/2005 |
| 6881842 | Process for producing tricyclic fused heterocyclic derivative A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the followi... | 04/19/2005 |
| 6849644 | Isoquinoline derivatives useful in the treatment of CNS disorders The invention relates to novel tetrahydroquinoline compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various CNS disorders. ... | 02/01/2005 |
| 6841678 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-am... | 01/11/2005 |
