Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 6506765 | Apomorphine derivatives and methods for their use Apomorphine derivative compounds; pharmaceutically active compositions of apomorphine derivative compounds; and the use of apomorphine derivative compounds in methods for treating sexual dysfunction or for enhancing apomorphine effectiveness for patients ... | 01/14/2003 |
| 6365597 | 4-aza steroids The invention related to 4-aza-17ଲ-(cyclopropoxy)-androst-5-androstan-3-one, 4-aza-17ଲ-(cyclopropylamino)-androst-4-en-3-one and related compounds and to compositions incorporating these compounds, as well as the inhibition of C | 04/02/2002 |
| 6352997 | Method of improving in-vitro fertilization The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a compound of structural formula I: ##STR1## to the subjec... | 03/05/2002 |
| 6204273 | 16-substituted-4-aza-androstane 5--reductase isozyme 1 inhibitors Compounds of the Formula I ##STR1## are inhibitors of the 5-reductase 1 isozyme, and are useful alone, or in combination with a 5-reductase 2 inhibitor, for the treatment of androgenic sensitive disorders such as acne vulgaris, seborrhea, fe... | 03/20/2001 |
| 6180794 | Process for the preparation of 1,2-dihydroquinolines A method for preparing 1,2-dihydroquinolines that is more flexible than the Skraup reaction is provided. The method comprises treating an ortho-alkenyl aniline with a ketone in the presence of a Lewis acid. Novel intermediates and products of this method ... | 01/30/2001 |
| 6143887 | Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones The novel process of the present invention involves the stereoselective synthesis of certain 16ଲ-substituted 4-aza-5-androstan-3-ones and the useful intermediates obtained therein.... | 11/07/2000 |
| 6127354 | Compounds with growth hormone releasing properties Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R1, L1 | 10/03/2000 |
| 6001846 | Process for the preparation of 1,2-dihydroquinolines A method for preparing 1,2-dihydroquinolines that is more flexible than the Skraup reaction is provided. The method comprises treating an ortho-alkenyl aniline with a ketone in the presence of a Lewis acid. Novel intermediates and products of this method ... | 12/14/1999 |
| 5935968 | Methods for treating polycystic ovary syndrome The present invention provides for a method of treating polycystic ovary syndrome in a subject in need of such treatment comprising the administration of a therapeutically effective amount of a compound of structural formula I: ##STR1## to the s... | 08/10/1999 |
| 5886005 | 4-Aza-19-norandrostane derivatives Compounds of the formula ##STR1## are inhibitors of 5-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern ... | 03/23/1999 |
| 5854273 | Bisimide compounds A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C | 12/29/1998 |
| 5739137 | 16-substituted-4-aza-3-oxo-androstane as 5-alpha-reductase isozyme 1 inhibitors Compounds of formula (I) are inhibitors of the 5-reductase 1 isozyme, and are useful alone, or in combination with a 5-reductase 2 inhibitor, for the treatment of androgenic sensitive disorders such as acne vulgaris, seborrhea, female hirsut... | 04/14/1998 |
| 5719158 | 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors Compounds of the Formula I ##STR1## are inhibitors of the 5-reductase 1 isozyme, and are useful alone, or in combination with a 5-reductase 2 inhibitor, for the treatment of androgenic sensitive disorders such as acne vulgaris, seborrhe... | 02/17/1998 |
| 5710275 | 7ଲ-substituted-4-aza-5-androstan-3-ones as 5-reductase inhibitors Described are new 7ଲ-substituted 4-aza-5-androstan-3-ones and related compounds as 5-reductase inhibitors.... | 01/20/1998 |
| 5696266 | Process for the stereoselective reduction of steroid enelactams The novel process of this invention involves the reduction of certain Ɗ-5 steroidal alkenes to selectively produce either the 5 or 5ଲ reduction products. Particularly, this invention involves reduction of Ɗ-5 steroidal alkenes using a rhodi... | 12/09/1997 |
| 5693809 | Substituted 4-aza-5-androstan-ones as 5-reductase inhibitors Described are new 16-substituted and 7,16-disubstituted 4-aza-5-androstan-3-ones and related compounds as 5-reductase inhibitors.... | 12/02/1997 |
| 5693647 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 12/02/1997 |
| 5688808 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 11/18/1997 |
| 5656613 | Treatment of hyperandrogenic conditions The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5-reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleoti... | 08/12/1997 |
| 5610162 | Ester derivatives of 4-aza-steroids Compounds of Formula (I), ##STR1## wherein X is sulfur or oxygen are inhibitors of the 5-reductase enzyme and isozymes thereof. The compounds are useful for the treatment of hyperandrogenic disease conditions and diseases of the skin and scalp... | 03/11/1997 |
| 5597832 | Tetracyclic compounds as dopamine agonists A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from: ##STR2## wherein R1, R2, R3, R... | 01/28/1997 |
| 5578726 | Process for producing 7 ଲ-substituted-4-aza-5 -androstan-3-ones Described is a new process for producing 7ଲ-substituted-4-aza-5-androstan-3-ones and related compounds which are 5-reductase inhibitors, consisting of reducing the corresponding androsteneone with lithium and liquid ammonia, contacting... | 11/26/1996 |
| 5543417 | Combination method of treating acne using 4-AZA-5-cholestan-ones and 4-AZA-5-androstan-ones as selective 5-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents Described is a combination method using selective inhibitors of 5-reductase 1 and/or 2 including 7ଲ-substituted 4-aza-5-cholestan-3-ones and related 4-aza-5-androstan-3-one compounds which are useful in the treatment of acne vul... | 08/06/1996 |
| 5536727 | 17-Ethers and thioethers of 4-aza-steroids Compounds of Formula I ##STR1## wherein Z contains an ether or thioether moeity, are inhibitors of the 5-reductase enzyme and isozymes thereof. The compounds are useful for the treatment of hyperandrogenic disease conditions and diseases of ... | 07/16/1996 |
| 5525608 | 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors Compounds of the formula ##STR1## are inhibitors of 5-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern ... | 06/11/1996 |
| 5516779 | 17ଲ-substituted-6-azasteroid derivatives useful as 5-reductase inhibitors Compounds of the formula ##STR1## are inhibitors of 5 -reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern ... | 05/14/1996 |
| 5359071 | 15-substituted 4-azasteroids Compounds of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from the group consisting of hydrogen and C1-10 alkyl; R2 is selected from the group consisting of hydrogen a... | 10/25/1994 |
| 5294701 | Anthracycline compounds and intermediates This invention provides novel anti-tumour compounds of the formula ##STR1## wherein R1 and R2 are hydrogen or together form an alkyl-, alkoxy- or OH-substituted aromatic group, which optionally contains an N atom as a hetero-ato... | 03/15/1994 |
| 5276053 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 01/04/1994 |
| 5215894 | Biological process for producing 17ଲ-N-monosubstituted carbamoyl-11-oxo-4-aza-5--androst-3-one testosterone-5- reductase inhibitors The present invention is concerned with a novel biotransformation process for producing 17ଲ-N-monosubstituted carbamoyl-11-oxo-4-aza-5--androst-3-ones of the formula: ##STR1## These compounds are testosterone 5- reductase inhibito... | 06/01/1993 |
| 5086059 | Bis-naphthalimides as anticancer agents There are provided novel bis-napthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing intermediates to such compounds.... | 02/04/1992 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 4914106 | Compositions and methods employing 2-oxa- or -aza-pregnan compounds for inhibiting androgen or supplying progestin in mammals A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X r... | 04/03/1990 |
| 4888336 | Steroid 5-alpha-reductase inhibitors Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit... | 12/19/1989 |
| 4874803 | Dianhydride coupled polymer stabilizers The present invention comprises reaction products resulting from the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides, as well as the use of such products. The polymer stabilizers of the invention ... | 10/17/1989 |
| 4863918 | Enamine quaternary compounds, methods of making and their use as muscle relaxants Disclosed are novel enamine quaternary compounds of the formula ##STR1## wherein m=1, 2 or 3 and n=1, 2 or 3 with the proviso that m+n=3, 4 or 5; R1 and R2 are independently lower alkyl or hydrogen, and R3 and R4... | 09/05/1989 |
| 4785103 | 2-oxa- or -aza-pregnane compounds A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X r... | 11/15/1988 |
| 4739062 | Method of producing paraquinones A new widely-applicable method has been found for synthesis of 9,10-anthraquinones and similar chemical compounds of wide use in industry and pharmacology, by reacting suitable aromatic substrates with activated dicarboxylic acids (more particularly dichl... | 04/19/1988 |
| 4732897 | Steroidic 5-reductase inhibitors The present invention relates to new 4-aza-17ଲ-substituted 5-androstan-3-ones, to a process for their preparation, to pharmacological compostions containing them, and to the use of said compounds as inhibitors of androgen action by means of t... | 03/22/1988 |
| 4377584 | 4-Aza-17ଲ-substituted-5-androstan-3-one-reductase inhibitors 4-Aza-17ଲ-substituted-5-androstan-3-ones and their A-homo analogs of the formula: ##STR1## where Formula (I) may also have the structure of partial Formulas (II) and/or (III); and pharmaceutically acceptable salts of the above compounds ... | 03/22/1983 |
