Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8115002 | Preparation of substituted morphinan-6-ones and salts and intermediates thereof The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof. ... | 02/14/2012 |
| 8080661 | Processes for the synthesis of tertiary amines The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-me... | 12/20/2011 |
| 7838677 | Processes for preparing morphinans and intermediates thereof The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a β,γ-bicyclic ketone compound to form a nordihydrothebainone product using the Grewe cyclization reaction is improved by forming a reaction mixt... | 11/23/2010 |
| 7834184 | Opiate intermediates and methods of synthesis Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. The intermediates are morphinane derivatives of formula (10), wherein X is a F or Cl and R... | 11/16/2010 |
| 7320984 | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y ... | 01/22/2008 |
| 7262298 | 4-hydroxybenzomorphans 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ... | 08/28/2007 |
| 7199129 | Derivatives of morphine-like opioid compounds The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of ... | 04/03/2007 |
| 7074265 | Ink jet recording liquid An ink jet recording liquid exhibiting superior image color and improved color image fastness is disclosed, comprising a medium and an oil-soluble dye represented by the following formulas ... | 07/11/2006 |
| 7057035 | N-hydroxysuccinimide process for conversion of phenols to carboxamides A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido ester is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccinimide in a solvent in the pre... | 06/06/2006 |
| 7011701 | Dye and ink jet printing ink A dye is disclosed, which is represented by the following formula: wherein Z is an atomic group necessary to form a 6-membered nitrogen containing aromatic ring; R11 is a hydrogen bonding group; R12 | 03/14/2006 |
| 6916364 | Ink jet recording liquid An ink jet recording liquid including a compound represented by the following Formula (1), (2) or (3): ... | 07/12/2005 |
| 6884802 | 6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyradazinyl radical, or an unsubstitute... | 04/26/2005 |
| 6844438 | N-substituted derivatives of morphinan and uses thereof The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 01/18/2005 |
| 6843839 | Ink, recording method, recording unit, ink cartridge, ink set, and recording apparatus Magenta ink exhibiting excellent coloration on various recording materials is provided according to the present invention. The magenta ink can realize high image densities and can produce images having superior light resistance. The magenta ink contains first and se... | 01/18/2005 |
| 6670370 | Dextromethorphan tannate The invention pertains to a composition comprising dextromethorphan tannate and to a method for preparing dextromethorphan tannate by reacting dextromethorphan at a temperature of about 80 to about 180° C. with tannic acid either neat or as an aqueous sl... | 12/30/2003 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6579883 | Fluorinated 3,4-dihydroquinoline derivatives used as NOS inhibitors The invention relates to compounds of formula (I), to a method for producing them and to their use in medicaments as NOS inhibitors. ##STR1##... | 06/17/2003 |
| 6538005 | Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##... | 03/25/2003 |
| 6534519 | Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##... | 03/18/2003 |
| 6534518 | Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##... | 03/18/2003 |
| 6479505 | 6-arylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##... | 11/12/2002 |
| 6476025 | Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics ##STR1##... | 11/05/2002 |
| 6410550 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds. pharmaceutical compositions conta... | 06/25/2002 |
| 6403794 | Substituted 2-amino-4-alkylamino-1,3,5-triazines as herbicides The invention relates to novel substituted 2-amino-4-alkylamino-1,3,5-triazines of the formula (I) ##STR1## in which R1 represents in each case optionally substituted alkyl having 2 to 6 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, R | 06/11/2002 |
| 6372756 | Epimorphian compound and its use A novel compound N-demethyl-sinomenine, a metabolite of the anti-arthritic alkaloid sinomenine, has been identified and characterized. The compound may be incorporated in a pharmaceutical composition and may be administered to patients for treatment of va... | 04/16/2002 |
| 6262266 | Method for preparing oxycodone A method for the preparation of oxycodone, and salts thereof, from codeine comprising oxidation of codeine to codeinone, formation of an dienolsilyl ether congener of codeinone in strong amine base, oxidation of the dienolsilyl ether congener using perace... | 07/17/2001 |
| 6262265 | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay Novel chemical analogs are disclosed for the essential heroin metabolite 6-O-acetyl morphine (6MAM). The analogs optionally can be made to contain protein reactive groups, and can be used to form protein conjugates, fluorescently labeled compounds, and so... | 07/17/2001 |
| 6174891 | Antipruritic agent This invention provides an antipruritic comprising an opiate .kappa. receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated w... | 01/16/2001 |
| 6127354 | Compounds with growth hormone releasing properties Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R1, L1 | 10/03/2000 |
| 6127378 | Phenanthridines substituted in the 6 position Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.... | 10/03/2000 |
| 6008354 | Preparation of noroxymorphone from morphine The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrex... | 12/28/1999 |
| 5948788 | Normorphine and normorphinone derivatives Normorphine and normorphinone derivatives are provided as compositions of matter.... | 09/07/1999 |
| 5905153 | Process for preparing (9,13,14)-1-(3-methoxy-morphinan-17-yl)alkanones (9, 13,14)-1-(3-Methoxymorphinan-17-yl)alkanones of the formula ##STR1## wherein R signifies lower alkanoyl, are valuable intermediates for the manufacture of dextromethorphan of the formula ##STR2## They can be produce... | 05/18/1999 |
| 5739145 | Antitussive agents There are provided novel antitussive agents different from existing antitussive agents or those under development. Antitussive agents containing morphinan derivatives represented by compound 6: ##STR1## or pharmacologically acceptable acid-addition s... | 04/14/1998 |
| 5731317 | Bridged piperidines promote release of growth hormone The present invention is directed to certain novel compounds identified as bridged piperidines of the general structural formula: ##STR1## wherein R1, R1a, R2a, R3, R3a,R4, R5, ... | 03/24/1998 |
| 5717098 | Process for the preparation of azanoradamantane benzamides A process for the preparation of a γ-lactone of the formula ##STR1## which can be used to produce a single enantiomer of aminoazanoradamantane which is coupled to aromatic acid moieties to produce compounds useful as 5-HT agonists or antagonists.... | 02/10/1998 |
| 5534521 | Benzimidazole compounds This invention relates to compounds useful in treating HT4 and/or HT3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof; pharmaceutical compositions containing the compounds and a method f... | 07/09/1996 |
| 5525727 | Brain-specific drug delivery The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula [D-DHC] (I) wherein [D] is a centrally acting drug ... | 06/11/1996 |
| 5504208 | Process for the preparation of 3, 14ଲ-dihydroxy-17-normorphinan Process for the preparation of 3,14ଲ-dihydroxy-17-normorphinan ##STR1## A suitable economic process for the preparation of 3,14ଲ-dihydroxy-17-normorphinan of a general formula (I) is being solved, which is a key intermediate of a semisynt... | 04/02/1996 |
| 5455248 | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts, and compositions and method of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 10/03/1995 |
