Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8163912 | Berberine compounds and processes for the preparation of berberine compounds The invention is directed to berberine compounds and processes for the preparation of berberine compounds through an intramolecular Bischler-Napieralski cyclization. ... | 04/24/2012 |
| 7375225 | 4-cyanocoumarin derivatives and uses thereof 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivatives have a f... | 05/20/2008 |
| 7338720 | Organic electroluminescent element An organic electroluminescent (EL) device which uses, as a luminescence-assisting agent, a novel coumarin derivative with a specific structure. The coumarin derivative effectively accelerates in such an organic EL device the transfer of excited energy in a host comp... | 03/04/2008 |
| 7252892 | Organic electroluminescence device An organic electroluminescent (EL) device which contains a novel coumarin derivative composed of a coumarin ring, a naphthalene ring with one or more hydrocarbon groups, and a five-membered hetero ring condensed with the naphthalene ring so as to give an electronic ... | 08/07/2007 |
| 6924372 | Benzopyrylo-polymethine-based hydrophilic markers The present invention relates to the field of optical-fluorescent markers, particularly to benzopyrylo-polymethine-based optical-fluorescent markers. ... | 08/02/2005 |
| 6897222 | Pyrido[2,1-a]isoquinoline derivatives The present invention provides compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically acc... | 05/24/2005 |
| 6765019 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. ... | 07/20/2004 |
| 6759536 | Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open readin... | 07/06/2004 |
| 6727261 | Pyrido[2,1-A]Isoquinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically accept... | 04/27/2004 |
| 6667304 | Polycyclic azaindole compounds The invention relates to compound of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or ... | 12/23/2003 |
| 6630482 | CFTR channel activator compounds and pharmaceutical compositions containing same CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic fibrosis, are discl... | 10/07/2003 |
| 6573380 | 4-cyanocoumarin derivatives and uses thereof 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivativ... | 06/03/2003 |
| 6495543 | Polycyclic azaindole compounds The invention relates to compounds of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together f... | 12/17/2002 |
| 6248884 | Extended rhodamine compounds useful as fluorescent labels Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure ##STR1## are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure ##STR2## I... | 06/19/2001 |
| 6239139 | 13,13A-Didehydroberbine derivatives The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, a compound of formula (1) below and the use of an extract or the c... | 05/29/2001 |
| 6184228 | Anti-sickling agents: selection methods and effective compounds The present invention is directed to a method for selecting compounds for use in treating sickle cell disease in a patient. The method comprises the steps of selecting a first set of HbS ligands from a first group of chemical compounds, selecting from the... | 02/06/2001 |
| 6028197 | Dibenzo[a,g]quinolizinium derivatives and the salts thereof The present invention provides a 5,6-dihydrodibenzo[a,g]quinolizinium derivative and the salts thereof of formula (I) which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, and the use of t... | 02/22/2000 |
| 6008356 | Pharmaceutically available protoberberine salts derivatives, and protoberberine salts derivatives, and protoberberine derivatives and salts thereof The novel compounds of the following chemical formulae (I) and (II) exhibit in vitro antifungal activity against fungi including cutaneous filamentous fungus, such as Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus or Candida.... | 12/28/1999 |
| 5932588 | Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties Camptothecin compounds having a --CH2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.... | 08/03/1999 |
| 5861421 | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.... | 01/19/1999 |
| 5760029 | Spirocycle integrin inhibitors This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3-8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro-4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are useful as antagonists of the v ଲ | 06/02/1998 |
| 5731317 | Bridged piperidines promote release of growth hormone The present invention is directed to certain novel compounds identified as bridged piperidines of the general structural formula: ##STR1## wherein R1, R1a, R2a, R3, R3a,R4, R5, ... | 03/24/1998 |
| 5702887 | Long emission wavelength chemiluminescent compounds and their use in test assays An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as... | 12/30/1997 |
| 5672600 | Antimicrobial dithiocarbamoyl quinolones Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heter... | 09/30/1997 |
| 5631256 | Antimicrobial quinolone thioureas Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic... | 05/20/1997 |
| 5620973 | Tetracyclic condensed heterocyclic compounds and their use A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R1 represents H or a hydrocarbon group which may be substituted; Y represents an amino or nitrogen-containing s... | 04/15/1997 |
| 5614517 | 8-Oxo-5,8-dihydro-6H-dibenzo[a,g]quinolizine-13-propanoic acid derivatives, their preparation and their therapeutic application A compound of formula (I) ##STR1## wherein X is hydrogen, halogen, C1 -C3 alkyl, trifluoromethyl, or C1 -C3 alkoxy; Y is hydrogen, halogen, C1 -C3 alkyl, or C1 -C3 alk... | 03/25/1997 |
| 5534521 | Benzimidazole compounds This invention relates to compounds useful in treating HT4 and/or HT3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof; pharmaceutical compositions containing the compounds and a method f... | 07/09/1996 |
| 5470852 | Tetrahydroprotoberberine quaternary ammonium compounds useful in for treating arrhythmia A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R1, R2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppres... | 11/28/1995 |
| 5380729 | 12-hetero substituted 6,11-ethano-6,11-dihydrobenzo (b) quinolizinium salts and compositions and method of use thereof 1-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 01/10/1995 |
| 5298509 | Octahydronaphthoquinolizines, and methods of making and using thereof Stereoisomeric substituted and/or unsubstituted octahydronaphthoquinolizines (OHNQs), and derivatives and analogs thereof are provided, including pharmaceutical and diagnostic compositions, as well as methods of making and using these compounds according ... | 03/29/1994 |
| 5281712 | Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom A novel chemiluminescent labeling compositions comprising an ester or thiolester covalently and jointly bonded to (1) a carbon of a heterocyclic ring or ring system that is susceptible to attack by peroxide or molecular oxygen and (2) an aryl ring or ring... | 01/25/1994 |
| 5142089 | Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye corresponding to the following formula - ##STR1## wherein Z represents CN, COOR1 or CONR2 R3 ; R1, R2 and R3 each independently represents hydrogen, substituted or unsubstituted alkyl, ... | 08/25/1992 |
| 5137909 | Indole derivative and method of production thereof An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R1, R2, R3, and R4 may ... | 08/11/1992 |
| 5049563 | Annelated indoleketones with an imidazolylalkyl substituent Annelated indoleketones with an imidazolylalkyl substituent having the formula (2): ##STR1## wherein R1 is alkyl or alkoxy having 1-4 C-atoms, hydroxy, halogen, trifluoromethyl, a group R5 R6 N or R5 R... | 09/17/1991 |
| 4920221 | Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]-phe... | 04/24/1990 |
| 4851416 | Berban derivatives as 2 -adrenergic antagonists The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R1 and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon... | 07/25/1989 |
| 4814452 | Enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one An enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one provides a key intermediate for the preparation of the 댒 -adrenergic antagonist (2R,12bS)-N-(1,3,4,6,7,12-hexahydro-2H-benzo[b]furo[2... | 03/21/1989 |
| 4645772 | Levorotatory enantiomers of derivatives of 5,6,13,13a-tetrahydro-8H-dibenzo [A,G]quinolizine, preparative process, pharmaceutical compositions containing them and application Levorotatory enantiomers of the derivatives of 5,6,13,13a-tetrahydro-8H-dibenzo-[a,g]-quinolizine of formula III ##STR1## wherein R'3 is hydrogen, an aryl or alkyl group or a --OR or --SR moiety wherein R is hydrogen, an aryl or alkyl grou... | 02/24/1987 |
| 4642373 | Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]-phe... | 02/10/1987 |
