Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7442710 | Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R... | 10/28/2008 |
| 7432276 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 10/07/2008 |
| 7423045 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 09/09/2008 |
| 7388016 | Dibenzonaphthyridine derivatives and methods of use thereof The present invention relates to Dibenzonaphthyridine Derivatives, compositions comprising an effective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a proliferative disorder, comprising administering to a subject in need thereof... | 06/17/2008 |
| 7307080 | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage The disclosure relates to compounds, pharmaceutical compositions and methods for inhibiting PARP by use of the disclosed compositions. The compounds of the disclosure have the following structures I, II and III: ... | 12/11/2007 |
| 7268143 | Isoquinoline derivatives and methods of use thereof The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 09/11/2007 |
| 7253179 | Fused heterocyclic compounds Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of ea... | 08/07/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7226924 | Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines, and methods for their preparation and use Substituted 3,4-dihydro-pyrimido[1,2a]pyrimidines and 3,4-dihydro-pyrazino[1,2a]pyrimidines of general formula I, the invention also relates to a method for the production thereof, substance libraries containing these compounds, medicaments which contain these compo... | 06/05/2007 |
| 7208492 | Topoisomerase-targeting agents The invention provides compounds of formula I or formula II: wherein: the bond represented by --- is a single bond or a double bond, and R1–R5, X, and Y have any of the meanin... | 04/24/2007 |
| 7169922 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 01/30/2007 |
| 7135478 | Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer. ... | 11/14/2006 |
| 7125885 | Fused heterocyclic compounds The present invention provides compounds having the formula: wherein R1, R2, R, R′ and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of ... | 10/24/2006 |
| 7064202 | Camptothecin intermediates and prodrugs and methods of preparation thereof The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs. ... | 06/20/2006 |
| 7026484 | Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ... | 04/11/2006 |
| 6992089 | Nitro and amino substituted topoisomerase agents The invention provides compounds of formula I: wherein R1-R9, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provide... | 01/31/2006 |
| 6989387 | Nitro and amino substituted topoisomerase agents The invention provides compounds of formula I: wherein R1–R9, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provid... | 01/24/2006 |
| 6984641 | Carboline derivatives as PDE5 inhibitors Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed. ... | 01/10/2006 |
| 6982333 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations. ... | 01/03/2006 |
| 6967215 | Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as an... | 11/22/2005 |
| 6946472 | Polycyclic compounds exhibiting anti-tumor activities This invention is concerned with novel polycyclic compounds of formula [I], wherein ring A, ring B, R1, R2, R3, R4, R5, R6, X, Y, R1′, R | 09/20/2005 |
| 6872743 | sPLA2 inhibitors A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 medi... | 03/29/2005 |
| 6858620 | Condensed pyridoindole derivatives Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed ... | 02/22/2005 |
| 6838456 | Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 01/04/2005 |
| 6828319 | Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 12/07/2004 |
| 6825209 | Compounds having unique CB1 receptor binding selectivity and methods for their production and use Compounds are provided that are amide analogs of SR141716A having unique CB1 receptor selectivity and providing WIN sparing binding characteristics, pharmaceutical compositions containing the compounds and their use in a method of treatment of CB1 receptor related d... | 11/30/2004 |
| 6824766 | Biodegradable high molecular weight polymeric linkers and their conjugates The present invention includes polymeric transport systems corresponding to the formula: wherein: R31 is a linear or branched polymer residue; Y10 and Y11 | 11/30/2004 |
| 6809104 | Fused heterocyclic compounds Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subs... | 10/26/2004 |
| 6737280 | Amidopyrylium fluorescence dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having structure (I) wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1-R8 are hydrogen, fluorine, chlorin... | 05/18/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6689290 | Family of conducting liquid crystals A mixture comprising a molecule of formula (I); in which A1, A2, A3, A4, A5 and A6, which may be the same or different, are each N or --CH; Y1, Y2, Y3, Y4 | 02/10/2004 |
| 6680326 | Polycyclic compounds Novel polycyclic compounds of the formula [I], ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, ring A, ring B, X, Y and Z are as defined herein and the pharmaceutically acceptable s... | 01/20/2004 |
| 6667304 | Polycyclic azaindole compounds The invention relates to compound of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or ... | 12/23/2003 |
| 6630481 | Viologen linked acridine based molecule and process for the preparation thereof The present invention provides a series of novel bifunctional molecules based on viologen linked acridine, bisacridine and bisacridinium salts of the general formula 1 (1a, 1b, 1c and 1d) and or pharmaceutically acceptable derivatives thereof, which can b... | 10/07/2003 |
| 6620937 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.... | 09/16/2003 |
| 6608076 | Camptothecin derivatives and polymeric conjugates thereof Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivative is opened and functionalized to allow attachment of a polymer such as PEG in th... | 08/19/2003 |
| 6545011 | Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.... | 04/08/2003 |
| 6534516 | Androgen receptor modulator compounds and methods Non-steroidal compounds that are high affinity, high selectivity modulators for androgen receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 03/18/2003 |
| 6500953 | Preparation of camptothecin and nothapodytine derivatives The invention concerns the preparation of nothapodytine or camptothecin derivatives which consists in causing 4-ethyl 2methyl hepta-2,4-dienoic acid act on a 3-aminomethyl 2-bromo quinoline derivative (III) wherein R1 and R2 are H or... | 12/31/2002 |
| 6495543 | Polycyclic azaindole compounds The invention relates to compounds of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together f... | 12/17/2002 |
