Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7939665 | Efficient process for the preparation of cabergoline and its intermediates This invention relates to a new and efficient process for the production of dopamine agonists such as Cabergoline and the intermediates thereof. ... | 05/10/2011 |
| 7858791 | Process for the preparation of cabergoline A process for preparing cabergoline (I) from ergoline-8β-carboxylic acid ester (XIII) comprising the following steps. (XIII), (XVI), (XVII), (XVIII), (XIX), (I). The present case also relates to the intermediates (XVI), (XVII), (XVIII) and (XIX) as well as the poly... | 12/28/2010 |
| 7339060 | Preparation of cabergoline A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a ... | 03/04/2008 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7238810 | Preparation of cabergoline A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 4-fluorotoluene or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabe... | 07/03/2007 |
| 7217822 | Process for making cabergoline A process for making cabergoline uses silyl-protecting agents to protect the indole nitrogen atom. ... | 05/15/2007 |
| 7186837 | Preparation of cabergoline The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed in a method for preparing cabergoline form I by combining... | 03/06/2007 |
| 7129261 | Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 10/31/2006 |
| 7115718 | Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material; a conj... | 10/03/2006 |
| 7087600 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 08/08/2006 |
| 7026483 | Forms of cabergoline The invention provides methods for preparing amorphous physical form of cabergoline, and solvate form A of cabergoline useful in the preparation of the first mentioned physical form. A method for treating a prolactin disorder with medicaments prepared from amorphous... | 04/11/2006 |
| 7019140 | Process for the synthesis of pergolide A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8βmethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from th... | 03/28/2006 |
| 6953854 | Process for preparing crystalline Form I of cabergoline A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of... | 10/11/2005 |
| 6838456 | Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 01/04/2005 |
| 6800635 | Crystalline form II of cabergoline Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from s solution of raw cabergoline in an organic solvent at low temperatures or submitting to a s... | 10/05/2004 |
| 6794496 | Immunoassay for LSD and 2-oxo-3-hydroxy-LSD The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indo... | 09/21/2004 |
| 6727363 | Process for preparing crystalline form I of cabergoline A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of... | 04/27/2004 |
| 6696568 | Process and intermediates for production of cabergoline and related compounds A process for preparation of N-(ergoline-8ଲ-carbonyl)ureas of the formula [I] their stereoisomers as well as acid addition salts thereof which process comprises silylating an ergoline-8ଲ-carboxamide of the formula [2], ##STR1## their ster... | 02/24/2004 |
| 6680327 | Crystalline form VII of cabergoline Crystalline form VII of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise a slurry procedure using form I or mixture of forms I and VII of cabergoline in a solvent at a temper... | 01/20/2004 |
| 6673806 | Crystalline form II cabergoline Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submit... | 01/06/2004 |
| 6548645 | Immunoassay for 2-oxo-3-hydroxy LSD To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an immunoassay reagent in which the 2-oxo-3-hydroxy-LSD is conju... | 04/15/2003 |
| 6476199 | Reagents for lysergic acid diethylamide immunoassay The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for the detection of LSD and nor-LSD. In the present invention t... | 11/05/2002 |
| 6403794 | Substituted 2-amino-4-alkylamino-1,3,5-triazines as herbicides The invention relates to novel substituted 2-amino-4-alkylamino-1,3,5-triazines of the formula (I) ##STR1## in which R1 represents in each case optionally substituted alkyl having 2 to 6 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, R | 06/11/2002 |
| 6310209 | Synthesis of CC-1065/duocarmycin analogs The present invention relates to a method for the synthesis of the dihydroindole C-ring found in CC-1065/duocarmycin analogs.... | 10/30/2001 |
| 6262265 | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay Novel chemical analogs are disclosed for the essential heroin metabolite 6-O-acetyl morphine (6MAM). The analogs optionally can be made to contain protein reactive groups, and can be used to form protein conjugates, fluorescently labeled compounds, and so... | 07/17/2001 |
| 6242603 | Process of preparing lysergic acid The present invention relates to a novel process for preparing lysergic acid by isomerizing paspalic acid, using a tetraalkylammonium hydroxide.... | 06/05/2001 |
| 5480885 | Ergoline derivatives of 1-propinylamine, a process for the manufacture thereof and the use thereof for medicaments A method of treating psychosis including administering an antipsychotically effective amount of an ergolinyl derivative of 2-propinylamine of the formula I ##STR1## wherein, R1, R2, and R3 independently represent a hy... | 01/02/1996 |
| 5441961 | Substituted cyclo or bicycloalkylamides of (8ଲ)-6-(substituted) ergolines The present invention provides (8ଲ)-N-substituted cyclo or bicycloalkyl-6-(substituted)-ergoline-8-carboxamides useful for occupying 5HT2 or 5HT1c receptors in mammals. The invention also provides methods for treating a variety... | 08/15/1995 |
| 5430031 | Serotoninergic ergoline derivatives The present invention provides compounds of the formula (I) ##STR1## wherein A, R1, R2 and R3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the... | 07/04/1995 |
| 5382669 | Process for the preparation of ergoline derivatives The invention provides a process for the preparation of ergoline derivatives of the formula I ##STR1## the process comprising reacting an ergoline amide of the formula II with an isocyanate of formula III ##STR2## in presence of a metal cat... | 01/17/1995 |
| 5288724 | Ergoline derivatives of 2-propinylamine, a process for the manufacture thereof and the use thereof for medicaments There are disclosed novel ergoline derivatives of 2-propinylamine of the general formula I ##STR1## wherein R1, R2 and R3 independently represent a hydrogen atom or a straight-chain or branched-chain C1 -C | 02/22/1994 |
| 5219862 | 8 beta-substituted ergolines, process for their production and their use Compounds of formula I ##STR1## in which R2 means optionally substituted C1-7 alkyl, C2-7 alkenyl, CH2 --O--C1-4 alkyl or CH2 --S--C1-4 alkyl R6 means C2-6 ... | 06/15/1993 |
| 5141944 | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides This invention provides N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides useful for blocking 5HT2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for tre... | 08/25/1992 |
| 5097031 | Steroselective hydrogenation process The invention relates to a novel stereoselective process for the preparation of dihdyrolysergol from lysergol by hydrogenation in the presence of solvent and palladium catalyst applied on a carrier, which comprises hydrogenating lysergol in the presence o... | 03/17/1992 |
| 5043341 | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides This invention provides N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides useful for blocking 5HT2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for tre... | 08/27/1991 |
| 4980475 | Process for the preparation of N-10 alpha-methoxyl-lumilysergol and esters, thereof, and intermediates for their preparation Processes for the preparation of esters of N1 -methyl-10-methoxylumilysergol are described, in which lysergol esters are subjected to N-methylation and subsequently to photochemical reaction with methanol/H2 SO4. Th... | 12/25/1990 |
| 4970314 | Process for the preparation of 2-bromo-8-ergolinyl compounds 2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R8 is NH2, NH--CONEt2, CONH2, ##STR2## and ##STR3## wherein R1 =C1-4 -alkyl and R2 =C1-4 ... | 11/13/1990 |
| 4968801 | Process for the production ergoline derivatives Ergoline derivatives of general Formula I ##STR1## wherein C8 C9 and C9 C10 are both CC-single bonds or one is a C.dbd.C-double bond, R6 is C1-4 alkyl, R8 is methyl, hydroxym... | 11/06/1990 |
| 4968802 | Process of making alkoxy cycloalkanol esters of dihydrolysergic acid Alkoxycycloalkyl esters of 1-substituted-6-C1-4 straight chain alkyl (or allyl)ergoline-8ଲ-carboxylic acids, useful as 5HT receptor antagonists.... | 11/06/1990 |
| 4939258 | Cycloalkanol esters of dihydrolysergic acid Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C1-4 straight chain alkyl (or allyl)-ergoline-8ଲ-carboxylic acids, useful as 5HT receptor antagonists.... | 07/03/1990 |
