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| Number | Title | Issue Date |
| 7019140 | Process for the synthesis of pergolide A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8βmethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from th... | 03/28/2006 |
| 6777406 | Substituted pyrroloquinolines and pyridoquinolines as serotinin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein is R1, R6a, R6b, R7 | 08/17/2004 |
| 6476021 | Compounds having cGMP-PDE inhibitory effect Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same; drugs characterized by containing at least one of these c... | 11/05/2002 |
| 6388079 | Process for preparing pergolide This invention relates to a process for preparing pergolide, which comprises the steps of reacting 9,10-dihydrolysergol with an acid anhydride at an elevated temperature in the presence of a catalyst to form a triacylated product intermediate; reducing th... | 05/14/2002 |
| 6087371 | Heterocyclyl-ergoline derivatives as 5-HT1A receptor ligands Ergoline derivative having formula (I) wherein R1 is hydrogen atom or C1-4 alkyl group; R2 is hydrogen, chlorine, or bromine atom, methyl or C1-4 alkylthio group; n is 0, 1 or 2; the substituent at position 8 is... | 07/11/2000 |
| 6060483 | Antineurodegenerative ergoline derivatives The present invention provides the new use in the treatment of neurodegenerative diseases with ergoline derivatives of formula (I) ##STR1## wherein R1 represents a hydrogen atom or a linear or branched C1 -C5 alkyl or... | 05/09/2000 |
| 5495032 | Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R3, R4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted w... | 02/27/1996 |
| 5463060 | One-pot process Pergolide is produced from 8,9-dihydroelymoclavine by a one-pot process in which it is reacted successively with 1-iodopropane, with a sulfonyl halide, and with an alkali metal thiomethoxide without isolation of intermediate products.... | 10/31/1995 |
| 5430031 | Serotoninergic ergoline derivatives The present invention provides compounds of the formula (I) ##STR1## wherein A, R1, R2 and R3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the... | 07/04/1995 |
| 5411966 | 2, 13-disubstituted ergolines, their production and use in pharmaceutical agents Compounds of formula I and their acid addition salts ##STR1## in which R2 R6 R13 and X have the meanings defined herein are described as well as a process and intermediates for their production, and pharmaceutical age... | 05/02/1995 |
| 5401748 | 2,14-disubstituted ergolines, their production and use in pharmaceutical compositions 2,14-Disubstituted ergolines of formula I ##STR1## in which R, R2, R6, R14 and X have the meaning named in the application, as well as their production and use in pharmaceutical agents, are described.... | 03/28/1995 |
| 5242678 | BR*-diagnostics for monoamine receptors Compounds of general Formula I labeled with 75 Br, 76 Br, 77 Br, 80m Br or 80 Br isotopes ##STR1## wherein R6 is a C1-6 hydrocarbon residue and C2 C3, ... | 09/07/1993 |
| 5212178 | 8-acylamino ergolines and use as pharmaceutical agents 8-acylamino ergolines are useful dopamine agonists.... | 05/18/1993 |
| 5158957 | 2-substituted ergolines 2-Substituted ergolines ##STR1## wherein C2 C3 and C9 C10 represent a single of double bond; X is oxygen or sulfur; R2 is C1-10 alkyl, optionally halogen-substituted C2-10 ... | 10/27/1992 |
| 5097031 | Steroselective hydrogenation process The invention relates to a novel stereoselective process for the preparation of dihdyrolysergol from lysergol by hydrogenation in the presence of solvent and palladium catalyst applied on a carrier, which comprises hydrogenating lysergol in the presence o... | 03/17/1992 |
| 5079364 | t-alkyl ergoline derivatives t-alkyl eroline derivatives of formula I are produced ##STR1## wherein (R1 =H, OCH3 and R2 H) or (R1 +R2 =a ring bond and R3 =H, optionally substituted nicotinynoyl or 1-oxo-2-cyclopen... | 01/07/1992 |
| 5077298 | Novel 8-acylaminoergolines Compounds of formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C3-7... | 12/31/1991 |
| 5075318 | 8-acylaminoergoline, its preparation and pharmaceutical compositions containing it 8-Acylaminoergoline useful in the treatment of psychotic disorders and Parkinson's disease.... | 12/24/1991 |
| 5037832 | 2-substituted ergolines 2-Substituted ergolines ##STR1## wherein C2 C3 and C9 C10 represent a single or double bond; X is oxygen or sulfur; R2 is C1-10 alkyl, optionally halogen-substituted C2-10 ... | 08/06/1991 |
| 4970314 | Process for the preparation of 2-bromo-8-ergolinyl compounds 2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R8 is NH2, NH--CONEt2, CONH2, ##STR2## and ##STR3## wherein R1 =C1-4 -alkyl and R2 =C1-4 ... | 11/13/1990 |
| 4968801 | Process for the production ergoline derivatives Ergoline derivatives of general Formula I ##STR1## wherein C8 C9 and C9 C10 are both CC-single bonds or one is a C.dbd.C-double bond, R6 is C1-4 alkyl, R8 is methyl, hydroxym... | 11/06/1990 |
| 4950672 | 2-substituted-8-branched chain acylaminoergolines Compounds of the formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C3-7 | 08/21/1990 |
| 4939258 | Cycloalkanol esters of dihydrolysergic acid Cycloalkyl or ketocycloalkyl esters of 1-substituted-6-C1-4 straight chain alkyl (or allyl)-ergoline-8ଲ-carboxylic acids, useful as 5HT receptor antagonists.... | 07/03/1990 |
| 4927926 | Derivatives of 7-(1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, their preparation and application as medicines The present invention relates to new heterocyclic compounds, derivatives of 7-(1-azetidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, characterized in that they correspond to formula (I) ##STR1## The invention also relates to the preparation of... | 05/22/1990 |
| 4910302 | Psychotropic polycyclic imides Compounds of the formula: ##STR1## in which Z is ##STR2## wherein X is alkylene, ethanylene or alkylidene; Q is alkylene, alkylidene, ##STR3## or Q, taken together with the carbon atoms to which it is attached forms a benzene ring... | 03/20/1990 |
| 4908449 | Process for preparing N-methyl derivatives of lysergol and 10-methoxylumilysergol A process for preparing 1-methyllysergol or 10-methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or 10-methoxylumilysergol in a polar aprotic solvent in such... | 03/13/1990 |
| 4874768 | 1,2-disubstituted ergolines useful for producing central antidopanminergic or 댒-receptor-blocking activity The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I ##STR1## wherein X is an oxygen or sulfur atom, R1 is a lower alkyl group, R2 is halogen, acyl, a saturated or unsaturated lower alkyl group whi... | 10/17/1989 |
| 4863929 | 12- and 13-substituted ergoline derivatives having alpha2 -receptor-blocking effect Novel 12- and 13-substituted ergoline derivatives are suitable, e.g., as psychopharmaceuticals and for hypertension therapy.... | 09/05/1989 |
| 4859678 | N-oxide ergolines as antihypertensive agents An ergoline derivative of the formula I: ##STR1## wherein R1 represents hydrogen or a methyl group; R2 represents hydrogen or a halogen atom, a methyl, cyano or phenyl group or an alkylthio group having from 1 to about 4 carbon ... | 08/22/1989 |
| 4857298 | I*-diagnostics for monoamine receptors using ergolines Compounds of general Formula I labeled with 121 I, 122 I, 123 I, 124 I, 125 I, 131 I and 132 I isotopes ##STR1## wherein R6 is a C1-6 aliphatic hydrocarbon ... | 08/15/1989 |
| 4853390 | (2-Haloergolinyl)-N'-N'-diethylurea compounds useful as medicinal agents E.G., as neuroleptics (2-Haloergolinyl)-N',N'-diethylurea derivatives of Formula I ##STR1## and the salts thereof, wherein R is hydrogen, alkyl of up to 6 carbon atoms, or alkenyl of up to 3 carbon atoms, X is halogen, ##STR2## is a CC single or CC double bond, and ... | 08/01/1989 |
| 4847262 | 2-substituted ergolines having neuroleptic and antidepressant activities Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C8 ---C9 and C9 ---C10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double ... | 07/11/1989 |
| 4841056 | Substituted hexahydro-4H-indolo[6,5,4-cd]indoles There are disclosed intermediates to pharmaceutical compounds of the formula ##STR1## in which R1 is an aliphatic or aromatic function, and R2 and R3 are each hydrogen, C1-4 alkyl or a protecting group; and... | 06/20/1989 |
| 4826851 | 2-substituted ergoline urea and thio-urea derivatives having neurolyptic/dopaminergic activity Novel 2-substituted ergolinyl urea and thioruea derivatives are disclosed, as well as their use as pharmaceuticals, specifically as neuroleptics. The compounds, which possess central dopaminergic activity, have the formula ##STR1## wherein X is an ox... | 05/02/1989 |
| 4826852 | Novel ergolinyl compounds nitrogen-substituted in the 8-position, useful for treating dopamine deficiency Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R1 is hydrogen, the 8-substituent can be in the - or ଲ-position and ... | 05/02/1989 |
| 4816587 | Process for the preparation of 2-halogenated ergoline derivatives The invention relates to a novel process for the halogenation in 2-position of ergot alkaloids. The process is characterized by that as a halogenating agent a system consisting of dimethylsulfoxide, a trialkylhalosilane or triarylhalosilane and optionally... | 03/28/1989 |
| 4801714 | Process for the preparation of ergolinylthioureas Ergolinylthioureas derivatives of the general Formula I ##STR1## wherein R1 is hydrogen, lower alkyl or acyl, R2 is hydrogen, halogen or a lower alkylthio group R3 is lower alkyl, R4, R5 and R6,... | 01/31/1989 |
| 4791115 | 2,6-dimethyl-8-pivaloylamino-9,10-didehydro-ergoline Compounds of formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C1-7... | 12/13/1988 |
| 4791116 | N,N-diethyl-N'-[(8)-1-ethyl-6-methyl-ergolin-8-yl]-sulfamide useful as prolactin secretion inhibitor, anti-parkinson agents and anti-depressant agents The present invention provides N,N-Diethyl-N'-[(8)-1-ethyl-6-methyl-ergolin-8-yl]-sulfamide, and N,N-Diethyl-N'-[(8)-1-isopropyl-6-methyl-ergolin-8-yl)-sulfamide useful as prolactin secretion inhibiton, anti-parkinson agents and anti-de... | 12/13/1988 |
| 4772610 | 1-alkyl ergolinylthiourea derivatives and their use as antidepressant agents Novel 1-alkyl ergolinylthiourea derivatives of the general formula ##STR1## wherein R1 is C1-6 alkyl, R2 and R3 are C1-4 alkyl, R4 is hydrogen or C1-4 alkyl and C9---- C | 09/20/1988 |
