Class 546/65 - Plural ring chalcogens in the tetracyclo ring system

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the tetracyclo ring system contains at
No. of patents: 100
Last issue date: 03/06/2012

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Number	Title	Issue Date
8129530	Catecholamine derivatives and prodrugs thereof The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy. ...	03/06/2012
7351830	Pancratistatin cyclic phosphate prodrugs and phenpanstatin cyclic phosphate prodrugs Selective phosphorylation of phenpanstatin (3a) with tetrabutylammonium dihydrogen phosphate and dicyclohexyl-carbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient mute to a new series (3	04/01/2008
7329676	2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors. ...	02/12/2008
7109327	Total synthesis of galanthamine, analogues and derivatives thereof The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form ═O, R3, R4	09/19/2006
6949647	Synthesis of pancratistatin (+)-Narciclasine (2), available in quantity from certain Amaryllidaceae species or by total synthesis, is employed in for a ten step synthetic conversion (3.6% overall yield) to natural (+)-pancratistatin (1a). The key procedures involve the epoxidation of na...	09/27/2005
6946472	Polycyclic compounds exhibiting anti-tumor activities This invention is concerned with novel polycyclic compounds of formula [I], wherein ring A, ring B, R1, R2, R3, R4, R5, R6, X, Y, R1′, R	09/20/2005
6936622	6-phenylbenzonaphthyridines Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE3/4 Inhibitors. ...	08/30/2005
6930114	Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer. ...	08/16/2005
6927292	Tricyclic epoxides The invention relates to compounds of Formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceutical active compounds. ...	08/09/2005
6884802	6-heteroarylphenanthridines Compounds of formula 1, in which Het is an unsubstituted or R6- and/or R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyradazinyl radical, or an unsubstitute...	04/26/2005
6812247	Organometallic complex A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, trifl...	11/02/2004
6699899	Substituted acylhydroxamic acids and method of reducing TNF଱ levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF଱ and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate....	03/02/2004
6696461	Tricyclic imidazopyridines Compounds of formula (I) in which the substituents as defined in the description are useful for preventing and treating gastrointestinal disorders. ##STR1##...	02/24/2004
6680326	Polycyclic compounds Novel polycyclic compounds of the formula [I], ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, ring A, ring B, X, Y and Z are as defined herein and the pharmaceutically acceptable s...	01/20/2004
6630483	Phenanthridine-N-oxides N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy ...	10/07/2003
6548515	Dihydrofuro[3,4-b]quinolin-1-one compounds The invention relates to compound of formula (I): ##STR1## wherein: {character pullout} represents a single or double bond, R0 represents hydrogen or hydroxy or alkoxy, R1 and R2, which are identical or different, each represents ...	04/15/2003
6538005	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##...	03/25/2003
6534518	Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6534519	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6479505	6-arylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	11/12/2002
6476025	Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics ##STR1##...	11/05/2002
6436952	Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity Compounds of the formula I, ##STR1## in which R1, R2, R3 and R4 have the meanings indicated in the description, are novel active bronchial therapeutics....	08/20/2002
6384045	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con...	05/07/2002
6355803	Near infrared chemiluminescent acridinium compounds and uses thereof This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional groups to the acridinium nucleus, with coplanarity of the ...	03/12/2002
6310208	Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines Since the compounds in accordance with the invention can bind to serotonin receptors (5HT2), they are especially suitable for the treatment or prevention of central nervous disorders such as depressions, bipolar disorders, anxiety states, sleep...	10/30/2001
6306869	N-oxides N-oxides of formula 1 ##STR1## wherein R1, R2, R3 and R4 have the meanings given in the description, are selective inhibitors of types 3 and 4 of cyclic nucleotide phosphodiesterase (PDE3, PDE4); they are useful on the one hand as bronchial therapeut...	10/23/2001
6214839	Substituted 6-alkylphenanthridines Compounds of formula I ##STR1## pharmaceutically acceptable salts thereof and compositions of either are useful for treating conditions amenable to treatment with a phosphodiesterase inhibitor type 4....	04/10/2001
6191279	Dipyrano-quinolinones useful as anti viral agents and a process for preparing the same The invention relates to novel dipyrano-quinolinone class of compounds having the general formula: ##STR1## Wherein R is hydrogen, alkyl optionally substituted about C-1 to C-10 alkenyl optionally substituted about C-1 to C-10 with one or more double ...	02/20/2001
6191138	Phenanthridines Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents. ##STR1##...	02/20/2001
6160119	Fused dihydropyrans Compounds of formula (I) in which the substituents have the meanings mentioned in the specification, are suitable for the prevention and treatment of gastrointestinal diseases. ##STR1##...	12/12/2000
6153645	Heterocycles as antimicrobial agents Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as ant...	11/28/2000
6127378	Phenanthridines substituted in the 6 position Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics....	10/03/2000
6114332	Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumor agents A compound which is a bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivative of formula (I): ##STR1## wherein each X, which may be the same or different in a given molecule, is --CH.dbd. or --N.dbd. each of R1 to R4 wh...	09/05/2000
6110910	Carbocyclic heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplanta...	08/29/2000
6107304	Thieno[2,3-b]pyrazolo[3,4-d]pyridine-3-ones to enhance erythropoiesis Invented are substituted thieno (2,3-b)pyrazolo(3,4-d)pyridin-3-ones, pharmaceutical compositions containing these compounds, and methods of using these compounds to enhance erythropoiesis. Also invented are intermediates and processess used in preparing ...	08/22/2000
6071929	Octahydro phenanthridine derivatives useful as NMDA-R receptor subtype blockers The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula: ##STR1## wherein: A is aryl R1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R--CO-- or R--COO--, wherein R is lower alkyl; R2	06/06/2000
6030967	Naphtholactams and lactones as bone morphogenetic protein active agents A compound of the formula: wherein Q is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1; Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group; Z1 is a C1...	02/29/2000
5958970	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond...	09/28/1999
5843952	Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati...	12/01/1998
5831114	Carbamate herbicides Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C1 -C3 haloalkoxy; Z is hydrogen or halogen; or Z and R together in the 2- an...	11/03/1998

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Class 546/65 - Plural ring chalcogens in the tetracyclo ring system