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| Number | Title | Issue Date |
| 8093390 | Substituted fused [1,2]imidazo[4,5-C] ring compounds and methods Fused [1,2]imidazo[4,5-c] ring compounds, e.g., fused [1,2]imidazo[4,5-c]quinolines and [1,2]imidazo[4,5-c]naphthyridines, with a substituent, e.g., a substituted alkoxy substituent, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds... | 01/10/2012 |
| 8034938 | Substituted chiral fused [1,2]imidazo[4,5-] ring compounds Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused r... | 10/11/2011 |
| 7615638 | Synthesis of grossularines-1 and analogs thereof and method of use In one embodiment of the present invention, a synthesis of grossularine-1 and N,N-didesmethylgrossularine-1 2 and analogs thereof based on a novel oxidative dimerization-electrocyclization sequence of 2-amino-4-(3-indolyl)imidazoles derived from oxotryptamine... | 11/10/2009 |
| 7291627 | Dihydroimidazo[5.1-a]-beta-carboline derivatives, method for their preparation, and their application as a drug The invention concerns dihydroimidazo[5,1-a]-β-carboline compounds of general formula (I) wherein in particular, R1, R2, R3, R4, R6 and R7... | 11/06/2007 |
| 7268141 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: | 09/11/2007 |
| 7144843 | Pest controllers An objective of the present invention is to provide a harmful organism control agent that possesses excellent control effect against harmful organisms and can be safely used. The present invention provides a compound of formula (1) or a salt thereof. The present inv... | 12/05/2006 |
| 7138408 | HIV integrase inhibitors, pharmaceutical compositions and methods for their use Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the a... | 11/21/2006 |
| 7026482 | Process for preparing imidazoquinolinamines A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof. ... | 04/11/2006 |
| 7001912 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity... | 02/21/2006 |
| 6967215 | Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as an... | 11/22/2005 |
| 6960585 | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R | 11/01/2005 |
| 6949646 | Imidazonaphthyridines Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful... | 09/27/2005 |
| 6949648 | Condensed pyrazole derivatives, process for producing the same and use thereof Novel pharmaceutical compositions for inhibiting Th2-selective immune response and pharmaceutical compositions for inhibiting cyclooxygenase comprising condensed pyrazole derivatives represented by the general formula (I): | 09/27/2005 |
| 6943171 | Polycyclic guanine derivative phosphodiesterase V inhibitors A compound having the formula (Ia) or (b), salt or solvate thereof, with the variables as defined herein, which can inhibit selectively phosphodiesterase V and can be useful for treating sexual dysfunction and other physiological disorders, symptoms and diseases: | 09/13/2005 |
| 6927292 | Tricyclic epoxides The invention relates to compounds of Formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceutical active compounds. ... | 08/09/2005 |
| 6911454 | Method for potentiating primary drugs in treating multidrug resistant disease The specification discloses a method for enhancing the inhibiting action of drugs against multidrug resistant cells, apparently by reversing or inhibiting the glycoprotein “pumps” associated with such cells. ... | 06/28/2005 |
| 6858620 | Condensed pyridoindole derivatives Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed ... | 02/22/2005 |
| 6852727 | Benzimisazo[4,5-f]isoquinolinone derivatives Benzimidazo[4,5-f]isoquinolinone derivatives are inhibitors of Janus protein tyrosine kinases (Jak), and as such are useful as immunosuppressants, and in the treatment of diseases including asthma, allergies, autoimmune diseases. ... | 02/08/2005 |
| 6838456 | Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 01/04/2005 |
| 6809096 | Phenanthroline-7-one derivatives and their therapeutic uses A pharmaceutical composition including an efficient amount of a compound selected among the compounds of formulae (I) and (Ia). The compounds have interesting cytotoxic properties leading to a therapeutic use as antitumoral medicines. | 10/26/2004 |
| 6747039 | Aza-benzothiopyranoindazoles with antitumor activity The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and methods of treating tumors and cancer in mammals with the compounds ... | 06/08/2004 |
| 6720420 | Photochromic oxazine compounds and methods for their manufacture The present invention provides oxazine compounds having aromatic, heteroaromatic, or aliphatic substituents at the 2 position of the oxazine moiety. Additionally, a one pot method with excellent yields is provided for producing the compounds ... | 04/13/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6686466 | Photochromic oxazine compounds and methods for their manufacture The present invention provides photochromic oxazine compounds and methods for their manufacture, which compounds are useful as photochromic compounds. The compounds of the invention have aromatic substituents on the 2 position of the oxazine moiety.... | 02/03/2004 |
| 6683142 | 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl ... | 01/27/2004 |
| 6667405 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): ##STR1## wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to f... | 12/23/2003 |
| 6664260 | Heterocyclic ether substituted imidazoquinolines Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesi... | 12/16/2003 |
| 6624305 | Process for preparing imidazoquinolinamines A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.... | 09/23/2003 |
| 6586595 | Process to prepare (5R)-(methylamino)-5, 6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII)... | 07/01/2003 |
| 6562964 | Heterocyclic compounds as inhibitors of rotamase enzymes Compounds of the formula (I): ##STR1## wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal r... | 05/13/2003 |
| 6541484 | Pyrazolo-pyridine derivatives as ligands for GABA receptors A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom adjacent the pyridine nucleus, and an optionally substituted cycl... | 04/01/2003 |
| 6476021 | Compounds having cGMP-PDE inhibitory effect Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same; drugs characterized by containing at least one of these c... | 11/05/2002 |
| 6469021 | Non-peptide antagonists of GLP-1 receptor and methods of use Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding... | 10/22/2002 |
| 6451809 | Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof where R1 -R4 and A are defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GAB... | 09/17/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6355802 | Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII).... | 03/12/2002 |
| 6353107 | 1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) ##STR1## wherein G1, G2, G3, G4 are independently C1 -C6 alkyl with... | 03/05/2002 |
| 6251890 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to carbapenem antibacterial agents of formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R2 represents: ##STR2## in formula I, in which the carbapenem nucleus is substituted at the 2-p... | 06/26/2001 |
| 6218400 | Treatment method using a cGMP-Specific PDE inhibitor A compound of formula ##STR1## and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and has u... | 04/17/2001 |
| 6153645 | Heterocycles as antimicrobial agents Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as ant... | 11/28/2000 |
