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| Number | Title | Issue Date |
| 8124770 | Fluorescent cellular markers A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38 (7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrob... | 02/28/2012 |
| 7960548 | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis Compounds and methods for treating, inhibiting, or delaying the onset of cancer in a subject by administering a therapeutically effective amount of a keratinocyte growth factor receptor tyrosine kinase (KGFR TK) inhibitor to the subject in need of such treatment. Al... | 06/14/2011 |
| 7605263 | Fluorescent naphthalene-1,4,5,8-tetracarboxylic bisimides with an electron-donating substituent on the nucleus Naphthalene-1,4,5,8-tetracarboxylic bisimides of the general formula I where the variables are defined as follows: R1 and R2 independently of one another are hydrogen, substituted or unsub... | 10/20/2009 |
| 7432276 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 10/07/2008 |
| 7423045 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 09/09/2008 |
| 7354927 | 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I: The invention further provides compositions including the compounds, methods for the use of the compounds, and methods of preparation o... | 04/08/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7220754 | Mono-ester and asymmetrically substatuted di-ester pro-drugs of dopamide D1 receptor agonists Mono-ester and asymmetrically substituted diesters of dihydrexidine, dinapsoline and A-86929 and substituted derivatives thereof are described. The novel ester/diester derivatives exhibit improved pharmacokinetic characteristics relative to their unesterified parent... | 05/22/2007 |
| 7214690 | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. ... | 05/08/2007 |
| 7199130 | Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists Substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds, and processes for the production thereof, pharmaceutical compositions containing these compounds and the use thereof in treatment methods and for the production of pharmaceut... | 04/03/2007 |
| 7169922 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 01/30/2007 |
| 7163946 | 5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 01/16/2007 |
| 7157196 | Naphthalenetetracarboxylic acid diimide derivatives and electrophotographic photoconductive material having the same Naphthalenetetracarboxylic acid diimide derivatives include a structure represented by the following formula: in which, R1, R2, and R3 are each independently any one selected from... | 01/02/2007 |
| 7135579 | Dibenzothiophene oxide compound, and process for producing the same There are disclosed novel compounds, liquid crystal compositions, polymers, optically anisotropic producgs, and optical or liquid crystal elements that have large refractive index anisotropy, mix easily with other liquid crystals, have advantageous stability against... | 11/14/2006 |
| 7084151 | 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 08/01/2006 |
| 7071205 | 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 07/04/2006 |
| 7026484 | Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ... | 04/11/2006 |
| 7011916 | Naphthalene tetracarboxylic diimide dimers A compound having the Formula I wherein: R1 is independently selected from the group consisting of a straight chain alkyl group, a branched alkyl group, a cycloalkyl group, ... | 03/14/2006 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6951942 | Glucocorticoid-selective anti-inflammatory agents Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also di... | 10/04/2005 |
| 6949647 | Synthesis of pancratistatin (+)-Narciclasine (2), available in quantity from certain Amaryllidaceae species or by total synthesis, is employed in for a ten step synthetic conversion (3.6% overall yield) to natural (+)-pancratistatin (1a). The key procedures involve the epoxidation of na... | 09/27/2005 |
| 6858620 | Condensed pyridoindole derivatives Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed ... | 02/22/2005 |
| 6828319 | Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 12/07/2004 |
| 6800625 | Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors The invention relates to novel 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives of the formula (I) and (IV): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and their... | 10/05/2004 |
| 6673930 | Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno [3,4-F] quinolines and derivatives thereof The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]q uinolines.... | 01/06/2004 |
| 6608193 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds Methods of preparing amino-substituted-tetrahydroisoquinoline ring compounds include the steps of providing a support-bound amino-substituted-tetrahydroisoquinoline compound; forming an intermediate by reacting the support-bound amino-substituted-tetrahyd... | 08/19/2003 |
| 6552198 | Method of stabilizing aqueous pyrazoloacridone derivative solution An aqueous solution of a pyrazoloacridone compound or pharmaceutical salt is stabilized using an acid, placing the solution in a well-closed container, evacuating air in the container, and sealing the container.... | 04/22/2003 |
| 6548515 | Dihydrofuro[3,4-b]quinolin-1-one compounds The invention relates to compound of formula (I): ##STR1## wherein: {character pullout} represents a single or double bond, R0 represents hydrogen or hydroxy or alkoxy, R1 and R2, which are identical or different, each represents ... | 04/15/2003 |
| 6545011 | Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.... | 04/08/2003 |
| 6521757 | Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents A method for the preparation of a compound of general Formula: ##STR1## or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general Formula: ##STR2## wherein, A... | 02/18/2003 |
| 6518430 | Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]q uinolines and derivatives thereof The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]q uinolines.... | 02/11/2003 |
| 6514983 | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: ##STR1## or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein Y is alkylhalo, alkyl-CO--G, COG, a direct bond... | 02/04/2003 |
| 6506766 | Glucocortiocoid-selective antinflammatory agents Compounds having Formula I ##STR1## are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical ... | 01/14/2003 |
| 6500953 | Preparation of camptothecin and nothapodytine derivatives The invention concerns the preparation of nothapodytine or camptothecin derivatives which consists in causing 4-ethyl 2methyl hepta-2,4-dienoic acid act on a 3-aminomethyl 2-bromo quinoline derivative (III) wherein R1 and R2 are H or... | 12/31/2002 |
| 6468996 | Substituted hetero-polycyclic compounds as PPAR and PPARγ activators The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 10/22/2002 |
| 6448405 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 09/10/2002 |
| 6426416 | Anthraquinone and condensed anthraquinone colorants having sulfonamido linked poly (oxyalkylene) moieties and their preparation The process for chemically modifying metal-free, colored anthraquinone or condensed anthraquinone compounds or the compounds prepared by said process for improving one or more properties thereof such as water dispersibility, compatibility with other organ... | 07/30/2002 |
| 6413977 | Chromeno[4,3,2-DE]isoquinolines as potent dopamine receptor ligands Novel dopamine receptor ligands of the formula: ##STR1## pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related dysfunction of the central or peripheral nervous system, are d... | 07/02/2002 |
| 6380207 | Glucocortiocoid-selective antiinflammatory agents Compounds having Formula I ##STR1## are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor in a mammal and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are ... | 04/30/2002 |
