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| Number | Title | Issue Date |
| 8168790 | Process for the preparation of 6-beta hydroxy morphinan compounds The invention provides processes for the conversion of a 6-keto morphinan to a 6-hydroxy morphinan. In particular, the invention provides a stereoselective process for the conversion of a 6-keto morphinan to a 6-beta-hydroxy morphinan. ... | 05/01/2012 |
| 7803942 | Crystals of morphinan derivative and process for producing the same The present invention is directed to provide 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride consistent in quality after production and having high purity. A crystal of 17-cyclopropylmethyl-3,14β-d... | 09/28/2010 |
| 7671203 | Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography An apparatus and method for separating at least one narcotic alkaloid that includes loading a stationary phase media into a high performance preparative liquid chromatography column, feeding a crude narcotic alkaloid solution into the chromatographic column, applyin... | 03/02/2010 |
| 7495098 | Extraction of alkaloids from opium A method for extracting at least one alkaloid from opium that includes dissolving opium in a solvent, heating the dissolved opium solution, cooling the dissolved opium solution, adjusting the pH of the dissolved opium solution with at least one first weak acid, filt... | 02/24/2009 |
| 7465797 | 6-monoacetylmorphine derivatives useful in immunoassay Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an ... | 12/16/2008 |
| 7435817 | C-14 oxidation of morphine derivatives The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (... | 10/14/2008 |
| 7405301 | Chemical methods This invention relates to a method for N-demethylating an N-methyl morphinane comprising the steps of: (i) treating said N-methyl morphinane with an oxidizing agent to form the N-oxide morphinane; and (ii) treating said N-oxide morphinane with a reducing agent. This... | 07/29/2008 |
| 7399858 | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof A method for the catalytic production of hydrocodone derivatives and hydromorphone derivatives, respectively, utilizing a transition metal catalyst of the formula [M(PR4R5R6)nXm]p; wherein M is a Grou... | 07/15/2008 |
| 7399859 | Method for catalytic preparation of hydromorphone and hydrocodone The present invention generally relates to catalysts of formula (III) [M(P(Ra)(Rb)N(Rc)(Rd))2Xn]mYp that selectively convert morphin... | 07/15/2008 |
| 7348430 | Production of opioid analgesics The present invention includes a process for the manufacture of dihydrothebaine, dihydrocodeinone enol acetate, hydrocodone, and analogs thereof by reacting dihydrocodeine or analogs thereof with benzophenone in the presence of potassium tert-alkylate in a hydrocarb... | 03/25/2008 |
| 7323565 | Method for the catalytic production of hydrocodone and hydromorphone A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal complex of a tertiary phosphine halide as catalyst. ... | 01/29/2008 |
| 7320984 | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y ... | 01/22/2008 |
| 7321038 | Method for the catalytic production of hydrocodone and hydromorphone A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal catalyst of the formula [M(PR3R4R5)nXm]p; ... | 01/22/2008 |
| 7319105 | Cytotoxic agents The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treat... | 01/15/2008 |
| 7285665 | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts A process for the preparation of a quaternary derivative of the morphinan alkaloid, the process comprising contacting a tertiary N-substituted morphinan alkaloid with an alkyl halide in an anhydrous solvent system, wherein the solvent system comprises an aprotic dip... | 10/23/2007 |
| 7279579 | Polymorphic forms of naltrexone This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorpora... | 10/09/2007 |
| 7232829 | Therapeutic compounds and methods The invention provides kappa receptor agonists of formula (I) and delta receptor antagonists of formula (II), wherein R1–R6 X and n have any of the meanings given in the specification, as well as compositions comprising them, methods for thei... | 06/19/2007 |
| 7230005 | Compounds and methods for lowering the abuse potential and extending the duration of action of a drug The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained releas... | 06/12/2007 |
| 7199129 | Derivatives of morphine-like opioid compounds The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of ... | 04/03/2007 |
| 7164021 | Opiate analogs selective for the δ-opioid receptor Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid recept... | 01/16/2007 |
| 7153966 | Preparation of oxycodone A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture ... | 12/26/2006 |
| 7129248 | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 10/31/2006 |
| 6972332 | Process for the production of opiates A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component i... | 12/06/2005 |
| 6958398 | Methods for making thebaine or its acid salts Methods for making thebaine and an acid salt of thebaine are disclosed herein. In one embodiment, an acid salt of thebaine is made from codeinone or an acid salt of one or more of the following: 8-methoxy-Δ6-dihydrothebaine, codeinone dimethyl ketal, and... | 10/25/2005 |
| 6949645 | Process for the production of opiates A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component i... | 09/27/2005 |
| 6946556 | Preparation of opioid analgesics by a one-pot process A one-pot process for preparing opioid analgesics such as hydrocodone, hydromorphone, and analogues thereof by reacting codeine, morphine, and analogues thereof with hydrogen in a solvent system of benzophenone and neutral solvent in the presence of a metal catalyst... | 09/20/2005 |
| 6936709 | Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2... | 08/30/2005 |
| 6887998 | Process for 8-carboxamido-2,6-methano-3-benzazocines 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as ana... | 05/03/2005 |
| 6887999 | Preparation of dihydrocodeine from codeine A process for the preparation of dihydrocodeine by hydrogenating codeine or a salt thereof in aqueous solution in the presence of a catalytic metal and deactivating agent that decreases impurities formation. ... | 05/03/2005 |
| 6864370 | Process for manufacturing oxycodone Oxycodone is manufactured in high yields and with a high purity using codeine or a salt of codeine as the starting material. The manufacturing process involves the following steps: (a) codeine or a codeine salt (e.g., codeine phosphate) is converted int... | 03/08/2005 |
| 6825205 | N-substituted hydromorphones and the use thereof This invention relates to N-substituted hydromorphones of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is C1-6 alkyl. These compounds act as μ opioid receptor... | 11/30/2004 |
| 6790959 | Process for manufacturing thebaine Thebaine is manufactured in high yields and with a high purity using codeine or a salt of codeine as the starting material. The manufacturing process involves the following steps: (a) codeine or a codeine salt (e.g., codeine phosphate) is converted into the i... | 09/14/2004 |
| 6784187 | 8-carboxamido-2,6-methano-3-benzazocines 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesi... | 08/31/2004 |
| 6784186 | Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of opioid compounds, particularly morphine and related compounds, in whic... | 08/31/2004 |
| 6740641 | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroi... | 05/25/2004 |
| 6703371 | Preparations for reducing oxygen consumption during physical efforts The invention relates to pharmaceutically active substances from the group comprising midazolam and compounds with a methyl-substituted nitrogen atom that is the ring atom of a nitrogenous heterocycle. These substances are used to reduce the oxygen consum... | 03/09/2004 |
| 6696457 | Morphinoid compounds Heterocycle condensed morphinoid derivatives of formula (I) have therapeutic utility as analgesics, in collagen disease, as anti-allergic and anti-inflammatory agents, brain cell protectants, in gastritis, diarrhoea, cardiovascular and respiratory disease... | 02/24/2004 |
| 6579985 | Preparation of codeine from morphine An improved process for the preparation of codeine from morphine comprises the steps of a) reacting morphine with a methylating agent in the presence of a hydrocarbon solvent at a temperature of 100 to 215° C. under reflux conditions such that approximat... | 06/17/2003 |
| 6559159 | Kappa opioid receptor ligands Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.... | 05/06/2003 |
| 6512117 | Hydromorphone and hydrocodone compositions and methods for their synthesis A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial... | 01/28/2003 |
