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| Number | Title | Issue Date |
| 8148527 | Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline The resolution of racemic 1-(4-methoxybenzyl)-octahydro-isoquinoline, a key intermediate in the synthesis of the antitussive agent dextromethorphan, is reported using (R)-2-(6-methoxy-2-naphthyl) propionic acid in good yields. The resolving agent and the undesired i... | 04/03/2012 |
| 8067596 | Processes for the production of (+)- “Nal” morphinan compounds The invention generally provides processes and intermediate compounds useful for the production of (+) nal morphinan compounds. In particular, the process encompasses synthetic routes for the production of (+) nal morphinan compounds or derivatives of (+) nal morphi... | 11/29/2011 |
| 7271173 | Mixed opioids and uses thereof This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation disease, such as schizophrenia, attention deficit hyperactivity disorder... | 09/18/2007 |
| 7229989 | Blue 3H-naphtho[2,1-b]pyran compounds and use thereof in photochromic articles Photochromic 3H-naphtho[2,1-b]pyran compounds corresponding to formula I in which the groups R1 to R7 and B′ have defined meanings and the use of such photochromic compounds in synthetic r... | 06/12/2007 |
| 7122534 | Aryl fused azapolycyclic compounds The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, R3 and Z are as defined herein, intermediates in the synthesis of ... | 10/17/2006 |
| 7026134 | Haptens, immunogens and antibodies to oxycodone and its metabolites Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group. ... | 04/11/2006 |
| 6972332 | Process for the production of opiates A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component i... | 12/06/2005 |
| 6949645 | Process for the production of opiates A morphine component, e.g., a concentrate of poppy straw, is converted into codeine in high yield and high purity and in a highly controlled manner. The conversion process involves the following steps: (a) providing a solution or suspension of a morphine component i... | 09/27/2005 |
| 6887999 | Preparation of dihydrocodeine from codeine A process for the preparation of dihydrocodeine by hydrogenating codeine or a salt thereof in aqueous solution in the presence of a catalytic metal and deactivating agent that decreases impurities formation. ... | 05/03/2005 |
| 6843839 | Ink, recording method, recording unit, ink cartridge, ink set, and recording apparatus Magenta ink exhibiting excellent coloration on various recording materials is provided according to the present invention. The magenta ink can realize high image densities and can produce images having superior light resistance. The magenta ink contains first and se... | 01/18/2005 |
| 6706702 | Aryl fused azapolycyclic compounds The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, R3 and Z are as defined herein, intermediates in the synthesis of su... | 03/16/2004 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6410550 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds. pharmaceutical compositions conta... | 06/25/2002 |
| 6365594 | Heterocycle-condensed morphinoid derivatives (II) Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, ##STR1## are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics. Pharmaceutical compositions containing such compound... | 04/02/2002 |
| 6225321 | Long analgesic acting nalbuphine polyester derivative and method of use The nalbuphine polyester derivative is related to a novel long acting agent. The nalbuphine polyester derivative is R--[CO-NAL]n wherein n is an integer from 2-4 and, in which the R is selected from a saturated or nonsaturated, substituted or u... | 05/01/2001 |
| 6194422 | Anthracycline derivatives The present invention provides imino aza-anthracyclinones and a method of treating amyloidoses using the same.... | 02/27/2001 |
| 5981540 | Heterocycle-condensed morphinoid derivatives Compounds of formula (I), are selective delta opioid agonsist and antagonists, and are useful as analgesics and in treating general neurologic disorders. ##STR1##... | 11/09/1999 |
| 5849750 | Dynemicin analogs Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.... | 12/15/1998 |
| 5843952 | Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 12/01/1998 |
| 5763451 | Dynemicin analogs Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.... | 06/09/1998 |
| 5686614 | Preparation of chiral 5-aminocarbonyl-5H-dibenzoa,d!cyclohepten-5,10-imines by optical resolution Disclosed are processes for resolving a racemic mixture of 5-aminocarbonyl-5H-dibenzoa,d!cyclohepten-5,10-imines into component enantiomers comprising recrystallizaton of diasteriomeric tartrate salts.... | 11/11/1997 |
| 5631264 | Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 05/20/1997 |
| 5622958 | Enediyne quinone imines and methods of preparation and use thereof A quinone imine enediyne possessing cytotoxic activity towards cancer cells having the general structure: ##STR1## wherein R1, R2 and R3 are independently the same or different and are H, Br, Cl, F, NH2, CO... | 04/22/1997 |
| 5554620 | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment of neurodegenerative disorders or neurotoxic injuries utilizing them, wherein the substituted 6,11-ethano-6,11-dihy... | 09/10/1996 |
| 5512577 | Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More specifically, the present invention relates to the prepara... | 04/30/1996 |
| 5434159 | 6,11-cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolines and compositions and method of use thereof 6,11'-Cyclyl-1,2,3,4,5,6,11,11a-octahydrobenzo[b]quinolizine derivatives, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 07/18/1995 |
| 5430036 | 6,11-substituted-6,11-dihydrobenzo[b]quinolizinium salts and compositions and method of use thereof 6,11-Substituted-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 07/04/1995 |
| 5315006 | Method of preparing polycyclic diamines Polycyclic diamines, incorporating a basic framework similar to [3.3.3]propellane, and derivatives of the basic polycyclic diamines and a process for preparing same are provided. The diamines are prepared by subjecting bispyridine compounds to electroredu... | 05/24/1994 |
| 5281710 | Dynemicin analogs: synthesis, methods of preparation and use A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting prope... | 01/25/1994 |
| 5276159 | Dynemicin analogs: syntheses, methods of preparation and use A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting prope... | 01/04/1994 |
| 5162331 | Aspernomine, an antiinsectan metabolite A tetrahydroquinoline alkaloid compound named "aspernomine" has been isolated from the sclerotia of the fungus Aspergillus nomius. Aspernomine has the structure: ##STR1## and is effective for controlling Lepidopteran insects.... | 11/10/1992 |
| 5124454 | Polycyclic diamines and method of preparation Polycyclic diamines, incorporating a basic framework similar to [3.3.3]propellane, and derivatives of the basic polycyclic diamines and a process for preparing same are provided. The diamines are prepared by subjecting bispyridine compounds to electroredu... | 06/23/1992 |
| 4996211 | Substituted dibenzocycloheptenimines The present invention provides a compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein one of R1, R2, R3 and R4 represents a hydrocarbon or hydrocarbyloxycarbonyl group an... | 02/26/1991 |
| 4973593 | Novel compounds for the treatment of hypertension Compounds of the formulae: ##STR1## are useful as anti-hypertensives.... | 11/27/1990 |
| 4929622 | 2,6-Methanopyrrolo-3-benzazocines Novel 2,6-methanopyrrolo-3-benzazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain utilizing compounds or compositions thereof are disclosed.... | 05/29/1990 |
| 4599341 | Substituted and bridged pyridines useful as calcium channel blockers Novel substituted and bridged pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.... | 07/08/1986 |
| 4587253 | Bridged pyridine compounds useful as calcium channel blockers and analgesics Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.... | 05/06/1986 |
| 4587251 | Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine derivatives, compositions and methods employing them for treating ulcers The invention relates to new indolo[2,3-g]cyclopent[a]indolizine derivatives of the formulae (II) ##STR1## and/or (III) ##STR2## wherein W is alkoxycarbonyl having from one to four carbon atoms in the alkoxy moiety or cyano, R1 i... | 05/06/1986 |
| 4558052 | 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them 10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the prep... | 12/10/1985 |
| 4554274 | Nb Quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10... | 11/19/1985 |
