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| Number | Title | Issue Date |
| 7795434 | Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in manufacture of medicaments Alkaloid reaction products obtainable in a process wherein alkaloids are reacted with an alkylating agent, preferably thiotepa, whereafter unreacted alkylating agent and other water-soluble compounds are removed from the reaction mixture by washing with water or a s... | 09/14/2010 |
| 7358362 | Method for the production of terylene-3,4:11,12-tetracarboxydiimides by direct synthesis A process for preparing terylene-3,4:11,12-tetracarboximides I where the variables are each defined as follows: R, R′ are each independently hydrogen; if desired substituted alkyl or cyc... | 04/15/2008 |
| 7319105 | Cytotoxic agents The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treat... | 01/15/2008 |
| 7294715 | Aporphine and oxoaporphine compounds and pharmaceutical use thereof The invention provides aporphine and oxoaporphine compounds that may be used to manufacture a medicaments for preventing or treating vascular dysfunctions that may result in ischemic and metabolic diseases or preventing complications associated with these diseases i... | 11/13/2007 |
| 7291732 | Isomeric fused pyrrolocarbazoles and isoindolones The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directe... | 11/06/2007 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| RE39707 | Camptothecin derivatives (20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is are optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treating canc... | 06/26/2007 |
| 7202255 | Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, | 04/10/2007 |
| 7189366 | Molecular tag reader Near infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read small quantities of selected molecular tags in tissues of fish or oth... | 03/13/2007 |
| 7169922 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 01/30/2007 |
| 7156907 | Multimeric dye structures The present invention is drawn to multimeric dyes, ink-jet inks, and systems that can be used to print images having good water fastness and humid fastness, as well as good color characteristics. Specifically, a multimeric dye for ink-jet printing can comprise a fir... | 01/02/2007 |
| 7122553 | Liposomal formulation of irinotecan The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the li... | 10/17/2006 |
| 7112677 | 1H-imidazo dimers 1H-imidazo dimer compounds are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic di... | 09/26/2006 |
| 7067666 | 7-substituted camptothecin and camptothecin analogs and methods for producing the same Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex. ... | 06/27/2006 |
| 7056535 | Triggered release from proteinoid microspheres The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the invention may be used to encapsulate a material or a compound and to... | 06/06/2006 |
| 7012079 | Optically pure camptothecin analogues The invention relates in particular to the compounds of general formula in which R1, R2, R3, R4, R5, R6 represent various radicals; their use as medicame... | 03/14/2006 |
| 7008568 | Photochromic naphthopyran compounds: compositions and articles containing those naphthopyran compounds A photochromic naphthopyran displays good color distribution when the naphthopyran has a central nucleus of the formula: wherein F is a 5-member, 6-member, or 7-member heterocyclic ring group ha... | 03/07/2006 |
| 7001906 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives Compounds of formula (I): wherein: W1 and W2, together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least o... | 02/21/2006 |
| 6872746 | Isomeric fused pyrrolocarbazoles and isoindolones The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directe... | 03/29/2005 |
| 6858732 | Photochromic benzodioxine fused naphthopyran compounds, compositions and articles containing those naphthopyran compounds Benzodioxino-naphtho[1,2-b]pyran compounds having particularly advantageous photochromic properties, such as, high sensitivity/coloration, two distinct absorption bands in the 430-500 nm range and 520-620 nm range of the visible spectrum may be generally described a... | 02/22/2005 |
| 6830833 | Organic light-emitting device based on fused conjugated compounds Fused conjugated polymers having the following general formula wherein X=C or N; R1-R16 is independently selected from H, D, alkyl, alkoxyl, silyl, aromatic ring, fused aromatic ring, heteroaromat... | 12/14/2004 |
| 6737280 | Amidopyrylium fluorescence dyes A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having structure (I) wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1-R8 are hydrogen, fluorine, chlorin... | 05/18/2004 |
| 6699876 | Camptothecin analogue compounds Compound of formula (I): ##STR1## wherein: n is 0, 1 or 2, R1 represents (C3 -C11)cycloalkyl or (C3 -C11)cycloalkylalkyl, R2, R3, R4 and R5 are selec... | 03/02/2004 |
| 6664396 | One step synthesis for quinacridone compounds Disclosed is a process for forming a N,N'-diarylquinacridone compound comprising the step of reacting a N,N'-unsubstituted quinacridone compound with a haloaryl compound in the presence of a metal or metal compound to arylate the N and N' positions and fo... | 12/16/2003 |
| 6642248 | Benzo[b]pyrano[3,2-h]acridin-7-one compounds A compound selected from those of formula (I): ##STR1## wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, --ORa, --NRaRb, --NRa--C(O)--T1, --O--C(O)--T | 11/04/2003 |
| 6620937 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.... | 09/16/2003 |
| 6525200 | Multicyclic aromatic compounds and uses thereof Multicyclic aromatic compounds useful as complexing agents having the general formula: ##STR1## Methods of complexing and quantitating a component in a sample such as urea or guanidine are also disclosed.... | 02/25/2003 |
| 6503919 | Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[b]pyrano[3,2-h]acridin carboxylate A compound selected from those of formula (I): ##STR1## wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents hy... | 01/07/2003 |
| 6504029 | Condensed-hexacyclic compounds and a process therefor Disclosed are a process for the preparation of a compound represented by the formula (1), which comprises treating a compound represented by the formula (2) with methanesulfonic acid and then subjecting the thus-treated compound to recrystallization; and ... | 01/07/2003 |
| 6410731 | Camptothecin analogs and methods of preparation thereof A method of synthesizing a compound having the formula ##STR1## via a cascade radical 4+1 annulation includes the step wherein the precursor ##STR2## or the precursor ##STR3## is reacted with an arylisonitrile having the formula ##STR4## wherein... | 06/25/2002 |
| 6407115 | Hexa-cyclic compound Accordingly, an object of this invention is to provide a hexa-cyclic compound represented by the following general formula: ##STR1## wherein R1 and R2 individually represent a hydrogen atom, a hydroxyl group, a C1-6 alkyl ... | 06/18/2002 |
| 6372907 | Water-soluble rhodamine dye peptide conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye... | 04/16/2002 |
| 6365594 | Heterocycle-condensed morphinoid derivatives (II) Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, ##STR1## are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics. Pharmaceutical compositions containing such compound... | 04/02/2002 |
| 6350756 | Camptothecin derivatives (20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treatin... | 02/26/2002 |
| 6310207 | Process of preparing camptothecin derivatives A process of preparing camptothecin derivatives of formula 1 is disclosed ##STR1##... | 10/30/2001 |
| 6288073 | Acronycine derivatives, preparation method and pharmaceutical compositions A compound selected from those of formula (I): ##STR1## in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents h... | 09/11/2001 |
| 6288072 | Camptothecin ଲ-alanine esters with topoisomerase I inhibition ଲ-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.... | 09/11/2001 |
| 6268375 | 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition Camptothecin compounds having a C10 11 O--(CF2)n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA c... | 07/31/2001 |
| 6248884 | Extended rhodamine compounds useful as fluorescent labels Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure ##STR1## are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure ##STR2## I... | 06/19/2001 |
| 6211371 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof A method of synthesizing compounds having the formula ##STR1## via a 4+1 radical annulation/cyclization wherein the precursor ##STR2## is reacted with an aryl isonitrile having the formula ##STR3## wherein X is selected from the group consisting of Br and... | 04/03/2001 |
