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| Number | Title | Issue Date |
| 8106201 | Process for the synthesis of morphinane compounds and intermediates thereof This invention relates to intermediates useful in the preparation of opiate alkaloids, particularly morphinane compounds. The invention also relates to processes for preparing such intermediates and to processes which utilise such intermediates in the synthesis of m... | 01/31/2012 |
| 8017777 | Process for the preparation of buprenorphine and derivatives for buprenorphine The invention generally provides processes for the production of buprenophine and derivatives of buprenorphine. In particular, the process may encompass synthetic routes for the production of buprenorphine or derivatives of buprenorphine from norhydromorphone or der... | 09/13/2011 |
| 7405301 | Chemical methods This invention relates to a method for N-demethylating an N-methyl morphinane comprising the steps of: (i) treating said N-methyl morphinane with an oxidizing agent to form the N-oxide morphinane; and (ii) treating said N-oxide morphinane with a reducing agent. This... | 07/29/2008 |
| 7220842 | Immunoassays for buprenorphine and norbuprenorphine Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) o... | 05/22/2007 |
| 7199129 | Derivatives of morphine-like opioid compounds The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of ... | 04/03/2007 |
| 7129248 | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 10/31/2006 |
| 7125884 | N-but-3-enyl norbuprenorphine and its use as analgesic The present invention provides compound having the structure: and pharmaceutically acceptable salts or derivatives thereof, as well as compositions including such compounds. The invention also provides methods of (1) preventing pain, (2) treating pain, (3) inducing ... | 10/24/2006 |
| 7119100 | Oripavine derivatives and their uses as pharmaceuticals The present invention relates to oripavine derivatives of formula (I), wherein R1 is hydrogen or methyl, R2 is methyl, cyclopropyl methyl, cyclobutyl methyl or allyl... | 10/10/2006 |
| 7084150 | Analogs and prodrugs of buprenorphine Disclosed are prodrugs and analogs of buprenorphine. ... | 08/01/2006 |
| 7074893 | Methods and compositions for the treatment of diseases associated with signal transduction aberrations The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not li... | 07/11/2006 |
| 7015326 | Pyridomorphinans, thienomorphinans and use thereof Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO | 03/21/2006 |
| 6965029 | Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by means of asymmetric, catalytic hydrogenation The invention relates to a process for the preparation of compounds of the general formula I in which R1 represents a C1-C20-alkyl group, a C3-C12-cycloalkyl group... | 11/15/2005 |
| 6946556 | Preparation of opioid analgesics by a one-pot process A one-pot process for preparing opioid analgesics such as hydrocodone, hydromorphone, and analogues thereof by reacting codeine, morphine, and analogues thereof with hydrogen in a solvent system of benzophenone and neutral solvent in the presence of a metal catalyst... | 09/20/2005 |
| 6916982 | Synthesis of perylene-porphyrin building blocks and polymers thereof for the production of light-harvesting arrays The present invention provides methods, compounds, and compositions for the synthesis of light harvesting arrays, such arrays comprising: (a) a first substrate comprising a first electrode; and (b) a layer of light harvesting rods electrically coupled to said first ... | 07/12/2005 |
| 6784186 | Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of opioid compounds, particularly morphine and related compounds, in whic... | 08/31/2004 |
| 6465479 | Pyridomorphinans and use thereof Compounds represented by the formula: ##STR1## wherein each of Y, X and R individually is H, OH, alkyl, alkoxy, aryl, halo, CF3 and NO2, provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts ... | 10/15/2002 |
| 6417365 | Method for recovering medicaments from preparations, and from the precursors or wastes thereof In a process for recovering medicinal substances or active substances from preparations, their initial products or waste, a flat-shaped starting material in the form of a film with adhesive and an active substance-containing material is provided with one ... | 07/09/2002 |
| 6395900 | Methods of O-demethylation and N-deprotection The present invention provides a method for N-deprotecting an opioid compound, a method for N-deprotecting and O-demethylating an opioid compound, a method for O-demethylating an opioid compound, and a method for O-demethylating a nonpeptidic delta agonis... | 05/28/2002 |
| 6365594 | Heterocycle-condensed morphinoid derivatives (II) Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, ##STR1## are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics. Pharmaceutical compositions containing such compound... | 04/02/2002 |
| 6359111 | Opioid receptor targeting A compound comprising a ligand portion which has binding affinity for an opioid receptor, and a therapeutically or diagnostically effective group selected from radionuclide chelating agents, fluorochromes, toxins, drugs, polyboron moieties, proteins, biol... | 03/19/2002 |
| 6355783 | Compounds for mass coloration of high temperature polymers The invention relates to novel soluble pigment precursors possessing not only higher thermal stability but also improved solubility characteristics and to a process for mass coloration of high temperature polymers that utilizes these novel soluble pigment... | 03/12/2002 |
| 6291675 | Methods of o-demethylation and n-deprotection The present invention provides a method for N-deprotecting an opioid compound, a method for N-deprotecting and O-demethylating an opioid compound, a method for O-demethylating an opioid compound, and a method for O-demethylating a nonpeptidic delta agonis... | 09/18/2001 |
| 6284769 | Nonpeptide kappa opioid receptor antagonists The compounds of structural formulae (I) and (II) ##STR1## and use of the compounds and salts and hydrates thereof, as therapeutic agents, is disclosed. A compound of formula (I) or (II) is an agonist for the μ and δ opioid receptors, an antagonist for ... | 09/04/2001 |
| 6187782 | Morphinane derivatives and medicinal use thereof Novel morphinan derivatives and pharmaceutically acceptable acid addition salts thereof as compounds having abilities to bind to opioid &3xb5;-receptor, which have agonist or antagonist activities, are disclosed. The morphinan derivatives according to the... | 02/13/2001 |
| 6136976 | Process for producing perylene-3, 4-dicarboxylic acid imides Perylene-3,4-dicarboximides I ##STR1## (R1 is hydrogen; C1 -C8 -alkyl; C5 -C8 -cycloalkyl; substituted or unsubstituted phenyl or naphthyl; R2 independently at each occurrence is hydrogen; ... | 10/24/2000 |
| 6008354 | Preparation of noroxymorphone from morphine The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrex... | 12/28/1999 |
| 5985887 | Aza-anthracyclinone derivatives Compounds of formula I ##STR1## wherein X1 and X2 are C.dbd.O, C.dbd.NH or CH2, X3 is CH2, CO, CHOH, ##STR2## wherein n=2 or, 3 or C.dbd.N(R9) wherein R9 is hydroxy or ... | 11/16/1999 |
| 5981540 | Heterocycle-condensed morphinoid derivatives Compounds of formula (I), are selective delta opioid agonsist and antagonists, and are useful as analgesics and in treating general neurologic disorders. ##STR1##... | 11/09/1999 |
| 5948788 | Normorphine and normorphinone derivatives Normorphine and normorphinone derivatives are provided as compositions of matter.... | 09/07/1999 |
| 5861411 | 4-Acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and... | 01/19/1999 |
| 5849915 | Buprenorphine analgesic analogues The object of this invention is to provide novel buprenorphine analgesic analogues represented by following formula(I) and their non-toxic pharmaceutically acceptable salts. ##STR1## wherein R1 is hydrogen atom, methyl, ethyl, cyclopropyl ... | 12/15/1998 |
| 5808073 | Preparation and purification of perylene-3,4-dicarbimides Preparation of perylene-3,4-dicarbimides by reaction of a perylene-3,4,9,10-tetracarboxylic acid or of the corresponding anhydrides with a primary amine by performing the reaction in the presence of a tertiary nitrogen base as solvent and of a transition ... | 09/15/1998 |
| 5770604 | Aconitine compound and an antipyretic/analgesic/anti-inflammatory agent This invention provides novel aconitine compounds of the formula (I) or salt thereof ##STR1## wherein, R1 is a hydrogen atom or hydroxyl group; R2 is an acetyloxy group; R3 is an alkyl having 1-4 carbon atoms; and R | 06/23/1998 |
| 5648359 | Tumor necrosis factor production inhibitors There is provided a composition for inhibiting the production or secretion of tumor necrosis factor effective for the treatment of cachexia, septic shock, multiple organ failure, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, osteoa... | 07/15/1997 |
| 5631263 | Use of delta opioid receptor antagonists to treat immunoregulatory disorders A therapeutic method is provided to elevate a depressed mammalian autologous mixed lymphocyte response and to alleviate the diseases associated therewith by the administration of an effective amount of certain selective delta opioid receptor antagonists t... | 05/20/1997 |
| 5631264 | Substituted 6,11-ethano-6,11-dihydrobenzo[B]quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 05/20/1997 |
| 5554620 | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment of neurodegenerative disorders or neurotoxic injuries utilizing them, wherein the substituted 6,11-ethano-6,11-dihy... | 09/10/1996 |
| 5552406 | Method for treating pain and brain perfusion abnormalities using mixed opioid agonist-antagonists A method for treating pain and brain perfusion abnormalities using mixed opiate agonist/antagonists is provided.... | 09/03/1996 |
| 5536728 | 4-acylaminopyridine derivative A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and... | 07/16/1996 |
| 5525727 | Brain-specific drug delivery The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula [D-DHC] (I) wherein [D] is a centrally acting drug ... | 06/11/1996 |
